Combined Alcohol Exposure and KRAS Mutation in Human Pancreatic Ductal Epithelial Cells Induces Proliferation and Alters Subtype Signatures Determined by Multi-Omics Analysis

SIMPLE SUMMARY: Pancreatic ductal adenocarcinoma is a deadly disease wherein alcohol use increases the risk of developing this cancer. Mutations in the KRAS oncogene are required for alcohol to promote pancreatic cancer in mice, but little is known about the molecular events associated with the comb...

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Detalles Bibliográficos
Autores principales: Clement, Emalie J., Law, Henry C.-H., Qiao, Fangfang, Noe, Dragana, Trevino, Jose G., Woods, Nicholas T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027648/
https://www.ncbi.nlm.nih.gov/pubmed/35454872
http://dx.doi.org/10.3390/cancers14081968

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