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E-cadherin Expression in Canine Gastric Carcinomas: Association with Clinicopathological Parameters
E-cadherin (E-cad) is a cell-adhesion molecule known for its tumor-invasion suppressor function. E-cad expression was examined immunohistochemically in a series of canine tissue samples, including normal gastric mucosa (NGM; n = 3), gastric carcinomas (GC; n = 33), adjacent non-neoplastic mucosa (NN...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027758/ https://www.ncbi.nlm.nih.gov/pubmed/35448670 http://dx.doi.org/10.3390/vetsci9040172 |
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author | Flores, Ana R. Rêma, Alexandra Mesquita, João R. Taulescu, Marian Seixas, Fernanda Gärtner, Fátima Amorim, Irina |
author_facet | Flores, Ana R. Rêma, Alexandra Mesquita, João R. Taulescu, Marian Seixas, Fernanda Gärtner, Fátima Amorim, Irina |
author_sort | Flores, Ana R. |
collection | PubMed |
description | E-cadherin (E-cad) is a cell-adhesion molecule known for its tumor-invasion suppressor function. E-cad expression was examined immunohistochemically in a series of canine tissue samples, including normal gastric mucosa (NGM; n = 3), gastric carcinomas (GC; n = 33), adjacent non-neoplastic mucosa (NNM; n = 32), neoplastic emboli (n = 16) and metastatic lesions (n = 9). The relationship between E-cad expression and clinicopathological features were investigated. In NGM, epithelial cells showed strong latero-lateral membranous expression of E-cad, and this pattern was considered normal. The membranous staining was preserved in all specimens of NNM (100%), whereas abnormal E-cad expression was found in 87.9% of the GCs. A marked difference in E-cad expression was observed between normal and malignant tissues (p < 0.0002). Abnormal E-cad expression was significantly more frequent in poorly/undifferentiated carcinomas (96%) and diffuse (95%) and indeterminate carcinomas (100%) than in well-differentiated/intestinal ones (62.5%; p = 0.0115 and p = 0.0392, respectively). There was significant association between abnormal E-cad expression and the depth of invasion (p = 0.0117), and the presence neoplastic emboli (p = 0.0194). No statistically significant differences in E-cad expression were observed concerning tumor location, histological type according to WHO classification, and presence of metastatic lesions. Therefore, deregulation of E-cad expression may play a role in canine gastric carcinogenesis and in tumor progression; moreover, it might be a prognostic tool for canine gastric cancer. |
format | Online Article Text |
id | pubmed-9027758 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90277582022-04-23 E-cadherin Expression in Canine Gastric Carcinomas: Association with Clinicopathological Parameters Flores, Ana R. Rêma, Alexandra Mesquita, João R. Taulescu, Marian Seixas, Fernanda Gärtner, Fátima Amorim, Irina Vet Sci Article E-cadherin (E-cad) is a cell-adhesion molecule known for its tumor-invasion suppressor function. E-cad expression was examined immunohistochemically in a series of canine tissue samples, including normal gastric mucosa (NGM; n = 3), gastric carcinomas (GC; n = 33), adjacent non-neoplastic mucosa (NNM; n = 32), neoplastic emboli (n = 16) and metastatic lesions (n = 9). The relationship between E-cad expression and clinicopathological features were investigated. In NGM, epithelial cells showed strong latero-lateral membranous expression of E-cad, and this pattern was considered normal. The membranous staining was preserved in all specimens of NNM (100%), whereas abnormal E-cad expression was found in 87.9% of the GCs. A marked difference in E-cad expression was observed between normal and malignant tissues (p < 0.0002). Abnormal E-cad expression was significantly more frequent in poorly/undifferentiated carcinomas (96%) and diffuse (95%) and indeterminate carcinomas (100%) than in well-differentiated/intestinal ones (62.5%; p = 0.0115 and p = 0.0392, respectively). There was significant association between abnormal E-cad expression and the depth of invasion (p = 0.0117), and the presence neoplastic emboli (p = 0.0194). No statistically significant differences in E-cad expression were observed concerning tumor location, histological type according to WHO classification, and presence of metastatic lesions. Therefore, deregulation of E-cad expression may play a role in canine gastric carcinogenesis and in tumor progression; moreover, it might be a prognostic tool for canine gastric cancer. MDPI 2022-04-01 /pmc/articles/PMC9027758/ /pubmed/35448670 http://dx.doi.org/10.3390/vetsci9040172 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Flores, Ana R. Rêma, Alexandra Mesquita, João R. Taulescu, Marian Seixas, Fernanda Gärtner, Fátima Amorim, Irina E-cadherin Expression in Canine Gastric Carcinomas: Association with Clinicopathological Parameters |
title | E-cadherin Expression in Canine Gastric Carcinomas: Association with Clinicopathological Parameters |
title_full | E-cadherin Expression in Canine Gastric Carcinomas: Association with Clinicopathological Parameters |
title_fullStr | E-cadherin Expression in Canine Gastric Carcinomas: Association with Clinicopathological Parameters |
title_full_unstemmed | E-cadherin Expression in Canine Gastric Carcinomas: Association with Clinicopathological Parameters |
title_short | E-cadherin Expression in Canine Gastric Carcinomas: Association with Clinicopathological Parameters |
title_sort | e-cadherin expression in canine gastric carcinomas: association with clinicopathological parameters |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027758/ https://www.ncbi.nlm.nih.gov/pubmed/35448670 http://dx.doi.org/10.3390/vetsci9040172 |
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