WGCNA-Based DNA Methylation Profiling Analysis on Allopurinol-Induced Severe Cutaneous Adverse Reactions: A DNA Methylation Signature for Predisposing Drug Hypersensitivity

Background: The role of aberrant DNA methylation in allopurinol-induced severe cutaneous adverse reactions (SCARs) is incompletely understood. To fill the gap, we analyze the DNA methylation profiling in allopurinol-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) patients...

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Detalles Bibliográficos
Autores principales: Cheng, Lin, Sun, Bao, Xiong, Yan, Hu, Lei, Gao, Lichen, Li, Ji, Xie, Hongfu, Chen, Xiaoping, Zhang, Wei, Zhou, Hong-Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027774/
https://www.ncbi.nlm.nih.gov/pubmed/35455641
http://dx.doi.org/10.3390/jpm12040525

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