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Inorganic Nanoparticles in Bone Healing Applications
Modern biomedicine aims to develop integrated solutions that use medical, biotechnological, materials science, and engineering concepts to create functional alternatives for the specific, selective, and accurate management of medical conditions. In the particular case of tissue engineering, designin...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027776/ https://www.ncbi.nlm.nih.gov/pubmed/35456604 http://dx.doi.org/10.3390/pharmaceutics14040770 |
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author | Burdușel, Alexandra-Cristina Gherasim, Oana Andronescu, Ecaterina Grumezescu, Alexandru Mihai Ficai, Anton |
author_facet | Burdușel, Alexandra-Cristina Gherasim, Oana Andronescu, Ecaterina Grumezescu, Alexandru Mihai Ficai, Anton |
author_sort | Burdușel, Alexandra-Cristina |
collection | PubMed |
description | Modern biomedicine aims to develop integrated solutions that use medical, biotechnological, materials science, and engineering concepts to create functional alternatives for the specific, selective, and accurate management of medical conditions. In the particular case of tissue engineering, designing a model that simulates all tissue qualities and fulfills all tissue requirements is a continuous challenge in the field of bone regeneration. The therapeutic protocols used for bone healing applications are limited by the hierarchical nature and extensive vascularization of osseous tissue, especially in large bone lesions. In this regard, nanotechnology paves the way for a new era in bone treatment, repair and regeneration, by enabling the fabrication of complex nanostructures that are similar to those found in the natural bone and which exhibit multifunctional bioactivity. This review aims to lay out the tremendous outcomes of using inorganic nanoparticles in bone healing applications, including bone repair and regeneration, and modern therapeutic strategies for bone-related pathologies. |
format | Online Article Text |
id | pubmed-9027776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90277762022-04-23 Inorganic Nanoparticles in Bone Healing Applications Burdușel, Alexandra-Cristina Gherasim, Oana Andronescu, Ecaterina Grumezescu, Alexandru Mihai Ficai, Anton Pharmaceutics Review Modern biomedicine aims to develop integrated solutions that use medical, biotechnological, materials science, and engineering concepts to create functional alternatives for the specific, selective, and accurate management of medical conditions. In the particular case of tissue engineering, designing a model that simulates all tissue qualities and fulfills all tissue requirements is a continuous challenge in the field of bone regeneration. The therapeutic protocols used for bone healing applications are limited by the hierarchical nature and extensive vascularization of osseous tissue, especially in large bone lesions. In this regard, nanotechnology paves the way for a new era in bone treatment, repair and regeneration, by enabling the fabrication of complex nanostructures that are similar to those found in the natural bone and which exhibit multifunctional bioactivity. This review aims to lay out the tremendous outcomes of using inorganic nanoparticles in bone healing applications, including bone repair and regeneration, and modern therapeutic strategies for bone-related pathologies. MDPI 2022-03-31 /pmc/articles/PMC9027776/ /pubmed/35456604 http://dx.doi.org/10.3390/pharmaceutics14040770 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Burdușel, Alexandra-Cristina Gherasim, Oana Andronescu, Ecaterina Grumezescu, Alexandru Mihai Ficai, Anton Inorganic Nanoparticles in Bone Healing Applications |
title | Inorganic Nanoparticles in Bone Healing Applications |
title_full | Inorganic Nanoparticles in Bone Healing Applications |
title_fullStr | Inorganic Nanoparticles in Bone Healing Applications |
title_full_unstemmed | Inorganic Nanoparticles in Bone Healing Applications |
title_short | Inorganic Nanoparticles in Bone Healing Applications |
title_sort | inorganic nanoparticles in bone healing applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027776/ https://www.ncbi.nlm.nih.gov/pubmed/35456604 http://dx.doi.org/10.3390/pharmaceutics14040770 |
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