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Inorganic Nanoparticles in Bone Healing Applications

Modern biomedicine aims to develop integrated solutions that use medical, biotechnological, materials science, and engineering concepts to create functional alternatives for the specific, selective, and accurate management of medical conditions. In the particular case of tissue engineering, designin...

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Detalles Bibliográficos
Autores principales: Burdușel, Alexandra-Cristina, Gherasim, Oana, Andronescu, Ecaterina, Grumezescu, Alexandru Mihai, Ficai, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027776/
https://www.ncbi.nlm.nih.gov/pubmed/35456604
http://dx.doi.org/10.3390/pharmaceutics14040770
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author Burdușel, Alexandra-Cristina
Gherasim, Oana
Andronescu, Ecaterina
Grumezescu, Alexandru Mihai
Ficai, Anton
author_facet Burdușel, Alexandra-Cristina
Gherasim, Oana
Andronescu, Ecaterina
Grumezescu, Alexandru Mihai
Ficai, Anton
author_sort Burdușel, Alexandra-Cristina
collection PubMed
description Modern biomedicine aims to develop integrated solutions that use medical, biotechnological, materials science, and engineering concepts to create functional alternatives for the specific, selective, and accurate management of medical conditions. In the particular case of tissue engineering, designing a model that simulates all tissue qualities and fulfills all tissue requirements is a continuous challenge in the field of bone regeneration. The therapeutic protocols used for bone healing applications are limited by the hierarchical nature and extensive vascularization of osseous tissue, especially in large bone lesions. In this regard, nanotechnology paves the way for a new era in bone treatment, repair and regeneration, by enabling the fabrication of complex nanostructures that are similar to those found in the natural bone and which exhibit multifunctional bioactivity. This review aims to lay out the tremendous outcomes of using inorganic nanoparticles in bone healing applications, including bone repair and regeneration, and modern therapeutic strategies for bone-related pathologies.
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spelling pubmed-90277762022-04-23 Inorganic Nanoparticles in Bone Healing Applications Burdușel, Alexandra-Cristina Gherasim, Oana Andronescu, Ecaterina Grumezescu, Alexandru Mihai Ficai, Anton Pharmaceutics Review Modern biomedicine aims to develop integrated solutions that use medical, biotechnological, materials science, and engineering concepts to create functional alternatives for the specific, selective, and accurate management of medical conditions. In the particular case of tissue engineering, designing a model that simulates all tissue qualities and fulfills all tissue requirements is a continuous challenge in the field of bone regeneration. The therapeutic protocols used for bone healing applications are limited by the hierarchical nature and extensive vascularization of osseous tissue, especially in large bone lesions. In this regard, nanotechnology paves the way for a new era in bone treatment, repair and regeneration, by enabling the fabrication of complex nanostructures that are similar to those found in the natural bone and which exhibit multifunctional bioactivity. This review aims to lay out the tremendous outcomes of using inorganic nanoparticles in bone healing applications, including bone repair and regeneration, and modern therapeutic strategies for bone-related pathologies. MDPI 2022-03-31 /pmc/articles/PMC9027776/ /pubmed/35456604 http://dx.doi.org/10.3390/pharmaceutics14040770 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Burdușel, Alexandra-Cristina
Gherasim, Oana
Andronescu, Ecaterina
Grumezescu, Alexandru Mihai
Ficai, Anton
Inorganic Nanoparticles in Bone Healing Applications
title Inorganic Nanoparticles in Bone Healing Applications
title_full Inorganic Nanoparticles in Bone Healing Applications
title_fullStr Inorganic Nanoparticles in Bone Healing Applications
title_full_unstemmed Inorganic Nanoparticles in Bone Healing Applications
title_short Inorganic Nanoparticles in Bone Healing Applications
title_sort inorganic nanoparticles in bone healing applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027776/
https://www.ncbi.nlm.nih.gov/pubmed/35456604
http://dx.doi.org/10.3390/pharmaceutics14040770
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