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Amyloid and Tau Protein Concentrations in Children with Meningitis and Encephalitis
Alzheimer’s disease (AD) has emerged as a growing threat to human health. It is a multifactorial disorder, in which abnormal amyloid beta metabolism and neuroinflammation have been demonstrated to play a key role. Intrathecal inflammation can be triggered by infections and precede brain damage for y...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027807/ https://www.ncbi.nlm.nih.gov/pubmed/35458457 http://dx.doi.org/10.3390/v14040725 |
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author | Sulik, Artur Toczylowski, Kacper Kulczynska-Przybik, Agnieszka Mroczko, Barbara |
author_facet | Sulik, Artur Toczylowski, Kacper Kulczynska-Przybik, Agnieszka Mroczko, Barbara |
author_sort | Sulik, Artur |
collection | PubMed |
description | Alzheimer’s disease (AD) has emerged as a growing threat to human health. It is a multifactorial disorder, in which abnormal amyloid beta metabolism and neuroinflammation have been demonstrated to play a key role. Intrathecal inflammation can be triggered by infections and precede brain damage for years. We analyzed the influence of infections of the central nervous system on biomarkers that are crucially involved in AD pathology. Analyses of the cerebrospinal fluid (CSF) levels of Aβ(1–42), Aβ(1–40), Tau, and pTau proteins were performed in 53 children with neuroinfections of viral (n = 26) and bacterial origin (n = 19), and in controls (n = 8). We found no changes in CSF amyloid Aβ(1–42) concentrations, regardless of etiology. We showed an increase in tau and phosphorylated tau concentrations in purulent CNS infections of the brain, compared to other etiologies. Moreover, the total concentrations of tau in the CSF correlated with the CSF absolute number of neutrophils. These findings and the Aβ 42/40 concentration quotient discrepancies in CFS between meningitis and encephalitis suggest that infections may affect the metabolism of AD biomarkers. |
format | Online Article Text |
id | pubmed-9027807 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90278072022-04-23 Amyloid and Tau Protein Concentrations in Children with Meningitis and Encephalitis Sulik, Artur Toczylowski, Kacper Kulczynska-Przybik, Agnieszka Mroczko, Barbara Viruses Brief Report Alzheimer’s disease (AD) has emerged as a growing threat to human health. It is a multifactorial disorder, in which abnormal amyloid beta metabolism and neuroinflammation have been demonstrated to play a key role. Intrathecal inflammation can be triggered by infections and precede brain damage for years. We analyzed the influence of infections of the central nervous system on biomarkers that are crucially involved in AD pathology. Analyses of the cerebrospinal fluid (CSF) levels of Aβ(1–42), Aβ(1–40), Tau, and pTau proteins were performed in 53 children with neuroinfections of viral (n = 26) and bacterial origin (n = 19), and in controls (n = 8). We found no changes in CSF amyloid Aβ(1–42) concentrations, regardless of etiology. We showed an increase in tau and phosphorylated tau concentrations in purulent CNS infections of the brain, compared to other etiologies. Moreover, the total concentrations of tau in the CSF correlated with the CSF absolute number of neutrophils. These findings and the Aβ 42/40 concentration quotient discrepancies in CFS between meningitis and encephalitis suggest that infections may affect the metabolism of AD biomarkers. MDPI 2022-03-30 /pmc/articles/PMC9027807/ /pubmed/35458457 http://dx.doi.org/10.3390/v14040725 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Sulik, Artur Toczylowski, Kacper Kulczynska-Przybik, Agnieszka Mroczko, Barbara Amyloid and Tau Protein Concentrations in Children with Meningitis and Encephalitis |
title | Amyloid and Tau Protein Concentrations in Children with Meningitis and Encephalitis |
title_full | Amyloid and Tau Protein Concentrations in Children with Meningitis and Encephalitis |
title_fullStr | Amyloid and Tau Protein Concentrations in Children with Meningitis and Encephalitis |
title_full_unstemmed | Amyloid and Tau Protein Concentrations in Children with Meningitis and Encephalitis |
title_short | Amyloid and Tau Protein Concentrations in Children with Meningitis and Encephalitis |
title_sort | amyloid and tau protein concentrations in children with meningitis and encephalitis |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027807/ https://www.ncbi.nlm.nih.gov/pubmed/35458457 http://dx.doi.org/10.3390/v14040725 |
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