Management and Treatment of Patients with Chronic Hepatitis B: Towards Personalized Medicine

The currently available antiviral treatments (Peg-Interferon-α and Nucleos(t)ide Analogues, NA) for chronic hepatitis B (CHB) achieve a functional cure (serum HBsAg and HDV-DNA clearance) of HBV infection in a limited number of patients. Nevertheless, the continuous pharmacological suppression of vi...

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Autores principales: Colombatto, Piero, Coco, Barbara, Bonino, Ferruccio, Brunetto, Maurizia R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027850/
https://www.ncbi.nlm.nih.gov/pubmed/35458431
http://dx.doi.org/10.3390/v14040701
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author Colombatto, Piero
Coco, Barbara
Bonino, Ferruccio
Brunetto, Maurizia R.
author_facet Colombatto, Piero
Coco, Barbara
Bonino, Ferruccio
Brunetto, Maurizia R.
author_sort Colombatto, Piero
collection PubMed
description The currently available antiviral treatments (Peg-Interferon-α and Nucleos(t)ide Analogues, NA) for chronic hepatitis B (CHB) achieve a functional cure (serum HBsAg and HDV-DNA clearance) of HBV infection in a limited number of patients. Nevertheless, the continuous pharmacological suppression of viral replication by NA halts liver disease progression lowering the risk of HCC development and improving the survival. In the near future, to fully exploit the potential of old and new drugs for HBV treatment a personalized approach to the patients will be required according to an accurate definition of their virologic, immunologic and clinical profile.
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spelling pubmed-90278502022-04-23 Management and Treatment of Patients with Chronic Hepatitis B: Towards Personalized Medicine Colombatto, Piero Coco, Barbara Bonino, Ferruccio Brunetto, Maurizia R. Viruses Review The currently available antiviral treatments (Peg-Interferon-α and Nucleos(t)ide Analogues, NA) for chronic hepatitis B (CHB) achieve a functional cure (serum HBsAg and HDV-DNA clearance) of HBV infection in a limited number of patients. Nevertheless, the continuous pharmacological suppression of viral replication by NA halts liver disease progression lowering the risk of HCC development and improving the survival. In the near future, to fully exploit the potential of old and new drugs for HBV treatment a personalized approach to the patients will be required according to an accurate definition of their virologic, immunologic and clinical profile. MDPI 2022-03-28 /pmc/articles/PMC9027850/ /pubmed/35458431 http://dx.doi.org/10.3390/v14040701 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Colombatto, Piero
Coco, Barbara
Bonino, Ferruccio
Brunetto, Maurizia R.
Management and Treatment of Patients with Chronic Hepatitis B: Towards Personalized Medicine
title Management and Treatment of Patients with Chronic Hepatitis B: Towards Personalized Medicine
title_full Management and Treatment of Patients with Chronic Hepatitis B: Towards Personalized Medicine
title_fullStr Management and Treatment of Patients with Chronic Hepatitis B: Towards Personalized Medicine
title_full_unstemmed Management and Treatment of Patients with Chronic Hepatitis B: Towards Personalized Medicine
title_short Management and Treatment of Patients with Chronic Hepatitis B: Towards Personalized Medicine
title_sort management and treatment of patients with chronic hepatitis b: towards personalized medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027850/
https://www.ncbi.nlm.nih.gov/pubmed/35458431
http://dx.doi.org/10.3390/v14040701
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