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Antibody-mediated delivery of a viral MHC-I epitope into the cytosol of target tumor cells repurposes virus-specific CD8(+) T cells for cancer immunotherapy

BACKGROUND: Redirecting pre-existing virus-specific cytotoxic CD8(+) T lymphocytes (CTLs) to tumors by simulating a viral infection of the tumor cells has great potential for cancer immunotherapy. However, this strategy is limited by lack of amenable method for viral antigen delivery into the cytoso...

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Detalles Bibliográficos
Autores principales:	Jung, Keunok, Son, Min-Jeong, Lee, Se-Young, Kim, Jeong-Ah, Ko, Deok-Han, Yoo, Sojung, Kim, Chul-Ho, Kim, Yong-Sung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027861/ https://www.ncbi.nlm.nih.gov/pubmed/35459256 http://dx.doi.org/10.1186/s12943-022-01574-0

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