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Association of Abnormal Iron Status with the Occurrence and Prognosis of Peritoneal Dialysis-Related Peritonitis: A Longitudinal Data-Based 10-Year Retrospective Study

This retrospective study investigated the effect of iron status on peritonitis by analyzing longitudinal iron parameters in peritoneal dialysis (PD) patients. Patients who received PD at our center from 1 January 2006 to 31 December 2015 were included and followed up until 31 December 2017. Accordin...

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Autores principales: Diao, Xiangwen, Zheng, Zhiwei, Yi, Chunyan, Cao, Peiyi, Ye, Hongjian, Liu, Ruihua, Lin, Jianxiong, Chen, Wei, Mao, Haiping, Huang, Fengxian, Yang, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027868/
https://www.ncbi.nlm.nih.gov/pubmed/35458175
http://dx.doi.org/10.3390/nu14081613
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author Diao, Xiangwen
Zheng, Zhiwei
Yi, Chunyan
Cao, Peiyi
Ye, Hongjian
Liu, Ruihua
Lin, Jianxiong
Chen, Wei
Mao, Haiping
Huang, Fengxian
Yang, Xiao
author_facet Diao, Xiangwen
Zheng, Zhiwei
Yi, Chunyan
Cao, Peiyi
Ye, Hongjian
Liu, Ruihua
Lin, Jianxiong
Chen, Wei
Mao, Haiping
Huang, Fengxian
Yang, Xiao
author_sort Diao, Xiangwen
collection PubMed
description This retrospective study investigated the effect of iron status on peritonitis by analyzing longitudinal iron parameters in peritoneal dialysis (PD) patients. Patients who received PD at our center from 1 January 2006 to 31 December 2015 were included and followed up until 31 December 2017. According to the joint quartiles of baseline transferrin saturation and ferritin, iron status was categorized as reference iron status (RIS), absolute iron deficiency (AID), functional iron deficiency (FID), and high iron status (HIS). Generalized estimating equations and Cox regression models with time-dependent covariates were used. A total of 1258 PD patients were included; 752 (59.8%) were male, with a mean (±standard deviation) age of 47.4 (±14.9) years. During a median follow-up period of 35.5 (interquartile range, 18.4–60.0) months, 450 (34.3%) patients had 650 episodes of peritonitis. By analyzing longitudinal data, patients with AID were independently positively associated with the occurrence (adjusted odds ratio (AOR) = 1.45) and treatment failure of peritonitis (adjusted hazard ratio (AHR) = 1.85). Patients with HIS were positively associated with the treatment failure of peritonitis (AHR = 2.70). Longitudinal AID and HIS were associated with the episodes and poor prognosis of peritonitis. Active clinical monitoring and correction of iron imbalance in patients with PD are needed.
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spelling pubmed-90278682022-04-23 Association of Abnormal Iron Status with the Occurrence and Prognosis of Peritoneal Dialysis-Related Peritonitis: A Longitudinal Data-Based 10-Year Retrospective Study Diao, Xiangwen Zheng, Zhiwei Yi, Chunyan Cao, Peiyi Ye, Hongjian Liu, Ruihua Lin, Jianxiong Chen, Wei Mao, Haiping Huang, Fengxian Yang, Xiao Nutrients Article This retrospective study investigated the effect of iron status on peritonitis by analyzing longitudinal iron parameters in peritoneal dialysis (PD) patients. Patients who received PD at our center from 1 January 2006 to 31 December 2015 were included and followed up until 31 December 2017. According to the joint quartiles of baseline transferrin saturation and ferritin, iron status was categorized as reference iron status (RIS), absolute iron deficiency (AID), functional iron deficiency (FID), and high iron status (HIS). Generalized estimating equations and Cox regression models with time-dependent covariates were used. A total of 1258 PD patients were included; 752 (59.8%) were male, with a mean (±standard deviation) age of 47.4 (±14.9) years. During a median follow-up period of 35.5 (interquartile range, 18.4–60.0) months, 450 (34.3%) patients had 650 episodes of peritonitis. By analyzing longitudinal data, patients with AID were independently positively associated with the occurrence (adjusted odds ratio (AOR) = 1.45) and treatment failure of peritonitis (adjusted hazard ratio (AHR) = 1.85). Patients with HIS were positively associated with the treatment failure of peritonitis (AHR = 2.70). Longitudinal AID and HIS were associated with the episodes and poor prognosis of peritonitis. Active clinical monitoring and correction of iron imbalance in patients with PD are needed. MDPI 2022-04-13 /pmc/articles/PMC9027868/ /pubmed/35458175 http://dx.doi.org/10.3390/nu14081613 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Diao, Xiangwen
Zheng, Zhiwei
Yi, Chunyan
Cao, Peiyi
Ye, Hongjian
Liu, Ruihua
Lin, Jianxiong
Chen, Wei
Mao, Haiping
Huang, Fengxian
Yang, Xiao
Association of Abnormal Iron Status with the Occurrence and Prognosis of Peritoneal Dialysis-Related Peritonitis: A Longitudinal Data-Based 10-Year Retrospective Study
title Association of Abnormal Iron Status with the Occurrence and Prognosis of Peritoneal Dialysis-Related Peritonitis: A Longitudinal Data-Based 10-Year Retrospective Study
title_full Association of Abnormal Iron Status with the Occurrence and Prognosis of Peritoneal Dialysis-Related Peritonitis: A Longitudinal Data-Based 10-Year Retrospective Study
title_fullStr Association of Abnormal Iron Status with the Occurrence and Prognosis of Peritoneal Dialysis-Related Peritonitis: A Longitudinal Data-Based 10-Year Retrospective Study
title_full_unstemmed Association of Abnormal Iron Status with the Occurrence and Prognosis of Peritoneal Dialysis-Related Peritonitis: A Longitudinal Data-Based 10-Year Retrospective Study
title_short Association of Abnormal Iron Status with the Occurrence and Prognosis of Peritoneal Dialysis-Related Peritonitis: A Longitudinal Data-Based 10-Year Retrospective Study
title_sort association of abnormal iron status with the occurrence and prognosis of peritoneal dialysis-related peritonitis: a longitudinal data-based 10-year retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027868/
https://www.ncbi.nlm.nih.gov/pubmed/35458175
http://dx.doi.org/10.3390/nu14081613
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