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Development of New Thiophene-Containing Triaryl Pyrazoline Derivatives as PI3Kγ Inhibitors

A series of new thiophene-containing triaryl pyrazoline derivatives, 3a–3t, were synthesized and evaluated regarding PI3K inhibition activity and anti-tumor potency based on a trial of introducing significant moieties, including pyrazoline and thiophene, and simplifying the parallel ring structures....

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Detalles Bibliográficos
Autores principales:	Yang, Bing, Zhang, Bo, Zhao, Qun, Li, Jin, Shi, Yujun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027920/ https://www.ncbi.nlm.nih.gov/pubmed/35458602 http://dx.doi.org/10.3390/molecules27082404

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