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Pediatric Functional Abdominal Pain Disorders following COVID-19

Background: Functional abdominal pain disorders (FAPD) are a group of functional gastrointestinal disorders with multifactorial etiology and are subclassified using Rome IV criteria into a series of clinically distinct entities represented by irritable bowel syndrome, functional dyspepsia, abdominal...

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Autores principales: Stepan, Mioara Desdemona, Cioboata, Ramona, Vintilescu, Ştefăniţa Bianca, Vasile, Corina Maria, Osman, Andrei, Ciolofan, Mircea Sorin, Popescu, Mihaela, Petrovici, Ilaria Lorena, Zavate, Andrei Calin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027938/
https://www.ncbi.nlm.nih.gov/pubmed/35455000
http://dx.doi.org/10.3390/life12040509
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author Stepan, Mioara Desdemona
Cioboata, Ramona
Vintilescu, Ştefăniţa Bianca
Vasile, Corina Maria
Osman, Andrei
Ciolofan, Mircea Sorin
Popescu, Mihaela
Petrovici, Ilaria Lorena
Zavate, Andrei Calin
author_facet Stepan, Mioara Desdemona
Cioboata, Ramona
Vintilescu, Ştefăniţa Bianca
Vasile, Corina Maria
Osman, Andrei
Ciolofan, Mircea Sorin
Popescu, Mihaela
Petrovici, Ilaria Lorena
Zavate, Andrei Calin
author_sort Stepan, Mioara Desdemona
collection PubMed
description Background: Functional abdominal pain disorders (FAPD) are a group of functional gastrointestinal disorders with multifactorial etiology and are subclassified using Rome IV criteria into a series of clinically distinct entities represented by irritable bowel syndrome, functional dyspepsia, abdominal migraine and functional abdominal pain that is not otherwise specified. Digestive functional disorders associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may be mediated by the involvement of complex pathogenic mechanisms, which have been under investigation in children since the beginning of the coronavirus disease pandemic (COVID-19). Methods: In this retrospective, observational descriptive and analytical study, we investigated the presence of chronical functional abdominal pain in preschool children (4–6 years old) from the south-west of Romania in the pre-pandemic (18 cases) and COVID-19 pandemic period (34 cases), as well as the association with the COVID-19 positive and COVID-19 negative statuses, gender, environment origin, and viral infection-associated symptoms. Age-specific Rome IV criteria were used to diagnose functional abdominal pain. We performed an integrated statistical analysis of the results utilizing an electronic database in which we compared the data in order to assess the impact of COVID-19 on the clinical-epidemiological parameters analyzed. Results: In the pre-pandemic group, irritable bowel syndrome predominated (77.8%), followed by functional dyspepsia (22.2%), the other types of functional abdominal pain being absent, while for the pandemic group, irritable bowel syndrome was the most common (79.4%), followed by abdominal migraine (11.8%), abdominal dyspepsia (5.9%) and functional abdominal pain not otherwise specified (2.9%). We found a female/male ratio difference of 0.84 and an urban/rural ratio of 1.83 in favor of the pandemic group. These discrepancies were mainly caused by the differences between the COVID-19 positive and negative pandemic groups, where we observed statistical association of the positive pandemic group with IBS and urban environment, and a tendency of FAPDs diagnostic mainly with males. The predominant symptoms associated with COVID-19 positive cases were digestive (60.9%) or respiratory (39.1%). Conclusions: Our study demonstrates viral-mediated sensitivity of the gastrointestinal tract in preschool children, considering different clinical-epidemiological profiles related to the prevalence of FAPD and according to gender and environment origin, while the contribution of the pandemic context remains to be demonstrated in larger studies
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spelling pubmed-90279382022-04-23 Pediatric Functional Abdominal Pain Disorders following COVID-19 Stepan, Mioara Desdemona Cioboata, Ramona Vintilescu, Ştefăniţa Bianca Vasile, Corina Maria Osman, Andrei Ciolofan, Mircea Sorin Popescu, Mihaela Petrovici, Ilaria Lorena Zavate, Andrei Calin Life (Basel) Article Background: Functional abdominal pain disorders (FAPD) are a group of functional gastrointestinal disorders with multifactorial etiology and are subclassified using Rome IV criteria into a series of clinically distinct entities represented by irritable bowel syndrome, functional dyspepsia, abdominal migraine and functional abdominal pain that is not otherwise specified. Digestive functional disorders associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may be mediated by the involvement of complex pathogenic mechanisms, which have been under investigation in children since the beginning of the coronavirus disease pandemic (COVID-19). Methods: In this retrospective, observational descriptive and analytical study, we investigated the presence of chronical functional abdominal pain in preschool children (4–6 years old) from the south-west of Romania in the pre-pandemic (18 cases) and COVID-19 pandemic period (34 cases), as well as the association with the COVID-19 positive and COVID-19 negative statuses, gender, environment origin, and viral infection-associated symptoms. Age-specific Rome IV criteria were used to diagnose functional abdominal pain. We performed an integrated statistical analysis of the results utilizing an electronic database in which we compared the data in order to assess the impact of COVID-19 on the clinical-epidemiological parameters analyzed. Results: In the pre-pandemic group, irritable bowel syndrome predominated (77.8%), followed by functional dyspepsia (22.2%), the other types of functional abdominal pain being absent, while for the pandemic group, irritable bowel syndrome was the most common (79.4%), followed by abdominal migraine (11.8%), abdominal dyspepsia (5.9%) and functional abdominal pain not otherwise specified (2.9%). We found a female/male ratio difference of 0.84 and an urban/rural ratio of 1.83 in favor of the pandemic group. These discrepancies were mainly caused by the differences between the COVID-19 positive and negative pandemic groups, where we observed statistical association of the positive pandemic group with IBS and urban environment, and a tendency of FAPDs diagnostic mainly with males. The predominant symptoms associated with COVID-19 positive cases were digestive (60.9%) or respiratory (39.1%). Conclusions: Our study demonstrates viral-mediated sensitivity of the gastrointestinal tract in preschool children, considering different clinical-epidemiological profiles related to the prevalence of FAPD and according to gender and environment origin, while the contribution of the pandemic context remains to be demonstrated in larger studies MDPI 2022-03-30 /pmc/articles/PMC9027938/ /pubmed/35455000 http://dx.doi.org/10.3390/life12040509 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Stepan, Mioara Desdemona
Cioboata, Ramona
Vintilescu, Ştefăniţa Bianca
Vasile, Corina Maria
Osman, Andrei
Ciolofan, Mircea Sorin
Popescu, Mihaela
Petrovici, Ilaria Lorena
Zavate, Andrei Calin
Pediatric Functional Abdominal Pain Disorders following COVID-19
title Pediatric Functional Abdominal Pain Disorders following COVID-19
title_full Pediatric Functional Abdominal Pain Disorders following COVID-19
title_fullStr Pediatric Functional Abdominal Pain Disorders following COVID-19
title_full_unstemmed Pediatric Functional Abdominal Pain Disorders following COVID-19
title_short Pediatric Functional Abdominal Pain Disorders following COVID-19
title_sort pediatric functional abdominal pain disorders following covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027938/
https://www.ncbi.nlm.nih.gov/pubmed/35455000
http://dx.doi.org/10.3390/life12040509
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