Cargando…

CFTR Modulation Reduces SARS-CoV-2 Infection in Human Bronchial Epithelial Cells

People with cystic fibrosis should be considered at increased risk of developing severe symptoms of COVID-19. Strikingly, a broad array of evidence shows reduced spread of SARS-CoV-2 in these subjects, suggesting a potential role for CFTR in the regulation of SARS-CoV-2 infection/replication. Here,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lotti, Virginia, Merigo, Flavia, Lagni, Anna, Di Clemente, Andrea, Ligozzi, Marco, Bernardi, Paolo, Rossini, Giada, Concia, Ercole, Plebani, Roberto, Romano, Mario, Sbarbati, Andrea, Sorio, Claudio, Gibellini, Davide
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028056/ https://www.ncbi.nlm.nih.gov/pubmed/35456026 http://dx.doi.org/10.3390/cells11081347

Ejemplares similares

WS05.04 SARS-CoV-2 infection is reduced in both immortalised and primary CFTR-modulated human bronchial epithelial cells
por: Lotti, V., et al.
Publicado: (2022)

Ultrastructural Characterization of Human Bronchial Epithelial Cells during SARS-CoV-2 Infection: Morphological Comparison of Wild-Type and CFTR-Modified Cells
por: Merigo, Flavia, et al.
Publicado: (2022)

439 Cystic fibrosis transmembrane conductance regulator impairment strongly decreases SARS-CoV-2 replication in human bronchial epithelial cells
por: Sorio, C., et al.
Publicado: (2022)

CFTR Inhibitors Display In Vitro Antiviral Activity against SARS-CoV-2
por: Lagni, Anna, et al.
Publicado: (2023)

Crosslink between SARS-CoV-2 replication and cystic fibrosis hallmarks
por: Lotti, Virginia, et al.
Publicado: (2023)

Assessment of SARS-CoV-2 IgG and IgM antibody detection with a lateral flow immunoassay test
por: Diani, Erica, et al.
Publicado: (2021)

Vector-Transmitted Flaviviruses: An Antiviral Molecules Overview
por: Diani, Erica, et al.
Publicado: (2023)

Evaluation of saliva and nasopharyngeal swab sampling for genomic detection of SARS-CoV-2 in children accessing a pediatric emergency department during the second pandemic wave
por: Diani, Erica, et al.
Publicado: (2023)

COVID-19 Vaccine: Between Myth and Truth
por: Piccaluga, Pier Paolo, et al.
Publicado: (2022)

Did we forget the diffuse chemosensory system when studying COVID-19?
por: Veronese, Sheila, et al.
Publicado: (2021)

Cross-Immunization Against Respiratory Coronaviruses May Protect Children From SARS-CoV2: More Than a Simple Hypothesis?
por: Piccaluga, Pier Paolo, et al.
Publicado: (2021)

CFTR Modulators Rescue the Activity of CFTR in Colonoids Expressing the Complex Allele p.[R74W;V201M;D1270N]/dele22_24
por: Kleinfelder, Karina, et al.
Publicado: (2023)

Association of CFTR gene mutation with bronchial asthma
por: Maurya, Nutan, et al.
Publicado: (2012)

Pilocarpine-Induced Status Epilepticus in Rats Involves Ischemic and Excitotoxic Mechanisms
por: Fabene, Paolo Francesco, et al.
Publicado: (2007)

TiO(2)–Ag–NP adhesive photocatalytic films able to disinfect living indoor spaces with a straightforward approach
por: Chirumbolo, Salvatore, et al.
Publicado: (2023)

Ultrastructural Analysis of Rehydrated Human Donor Corneas After Air-Drying and Dissection by Femtosecond Laser
por: Pedrotti, Emilio, et al.
Publicado: (2021)

Mechanical Properties of Human Bronchial Epithelial Cells Expressing Wt- and Mutant CFTR
por: Carapeto, Ana P., et al.
Publicado: (2020)

Detection of SARS-CoV-2 Δ426 ORF8 Deletion Mutant Cluster in NGS Screening
por: Cecchetto, Riccardo, et al.
Publicado: (2023)

Glucose transporter expression in the human colon
por: Merigo, Flavia, et al.
Publicado: (2018)

Duplex real-time polymerase chain reaction assay for the detection of human KIPyV and WUPyV in nasopharyngeal aspirate pediatric samples
por: Ligozzi, Marco, et al.
Publicado: (2018)

Prevalence of and Short-term Changes in Conjunctival Manifestations Among Patients With SARS-CoV-2 Infection
por: Pedrotti, Emilio, et al.
Publicado: (2022)

Ionocytes and CFTR Chloride Channel Expression in Normal and Cystic Fibrosis Nasal and Bronchial Epithelial Cells
por: Scudieri, Paolo, et al.
Publicado: (2020)

Tgf-β1 Inhibits Cftr Biogenesis and Prevents Functional Rescue of ΔF508-Cftr in Primary Differentiated Human Bronchial Epithelial Cells
por: Snodgrass, Steven M., et al.
Publicado: (2013)

CFTR-Adenylyl Cyclase I Association Responsible for UTP Activation of CFTR in Well-Differentiated Primary Human Bronchial Cell Cultures
por: Namkung, Wan, et al.
Publicado: (2010)

Bitter tastants and artificial sweeteners activate a subset of epithelial cells in acute tissue slices of the rat trachea
por: Lasconi, Chiara, et al.
Publicado: (2019)

In vivo monitoring of lung inflammation in CFTR-deficient mice
por: Stellari, Fabio, et al.
Publicado: (2016)

CFTR Rescue by Lumacaftor (VX-809) Induces an Extensive Reorganization of Mitochondria in the Cystic Fibrosis Bronchial Epithelium
por: Braccia, Clarissa, et al.
Publicado: (2022)

SFPQ rescues F508del-CFTR expression and function in cystic fibrosis bronchial epithelial cells
por: Kumar, Parameet, et al.
Publicado: (2021)

Protective role of CFTR during fungal infection of cystic fibrosis bronchial epithelial cells with Aspergillus fumigatus
por: Illek, Beate, et al.
Publicado: (2023)

CFTR Correctors and Antioxidants Partially Normalize Lipid Imbalance but not Abnormal Basal Inflammatory Cytokine Profile in CF Bronchial Epithelial Cells
por: Veltman, Mieke, et al.
Publicado: (2021)

Theranostic Role of (32)P-ATP as Radiopharmaceutical for the Induction of Massive Cell Death within Avascular Tumor Core
por: Galiè, Mirco, et al.
Publicado: (2017)

CFTR mutations altering CFTR fragmentation
por: Tosoni, Kendra, et al.
Publicado: (2012)

Cigarette smoke promotes HIV infection of primary bronchial epithelium and additively suppresses CFTR function
por: Chinnapaiyan, S., et al.
Publicado: (2018)

Immunolocalization of leptin and leptin receptor in colorectal mucosa of ulcerative colitis, Crohn’s disease and control subjects with no inflammatory bowel disease
por: Merigo, Flavia, et al.
Publicado: (2020)

Interferon gamma inducible protein 16 (IFI16) expression is reduced in mantle cell lymphoma
por: Piccaluga, Pier Paolo, et al.
Publicado: (2019)

Theratyping of the Rare CFTR Variants E193K and R334W in Rectal Organoid-Derived Epithelial Monolayers
por: Ciciriello, Fabiana, et al.
Publicado: (2022)

Cost of care and antibiotic prescribing attitudes for community-acquired complicated intra-abdominal infections in Italy: a retrospective study
por: Dalfino, Lidia, et al.
Publicado: (2014)

Molecules Implicated in Glucose Homeostasis are Differentially Expressed in the Trachea of Lean and Obese Zucker Rats
por: Merigo, F., et al.
Publicado: (2015)

In silico analysis and theratyping of an ultra-rare CFTR genotype (W57G/A234D) in primary human rectal and nasal epithelial cells
por: Kleinfelder, Karina, et al.
Publicado: (2023)

Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells
por: Michaels, Wren E, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_u0jk24eu158redqn3rgmpdov8k