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Incidence Rate of Bee Venom Acupuncture Related Anaphylaxis: A Systematic Review
Background: Bee venom acupuncture (BVA) is an effective treatment method for various diseases. Bee venom, however, can cause adverse effects, even rarely including life-threatening anaphylaxis, so safety-related evidence is required. In this study, we systematically estimated the incidence rate of a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028116/ https://www.ncbi.nlm.nih.gov/pubmed/35448847 http://dx.doi.org/10.3390/toxins14040238 |
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author | Ko, Seong-Hwan Oh, Hyeon-Muk Kwon, Do-Young Yang, Jae-Eun Kim, Byung-Jun Ha, Hyun-Ju Lim, Eun-Jin Oh, Min-Seok Son, Chang-Gue Lee, Eun-Jung |
author_facet | Ko, Seong-Hwan Oh, Hyeon-Muk Kwon, Do-Young Yang, Jae-Eun Kim, Byung-Jun Ha, Hyun-Ju Lim, Eun-Jin Oh, Min-Seok Son, Chang-Gue Lee, Eun-Jung |
author_sort | Ko, Seong-Hwan |
collection | PubMed |
description | Background: Bee venom acupuncture (BVA) is an effective treatment method for various diseases. Bee venom, however, can cause adverse effects, even rarely including life-threatening anaphylaxis, so safety-related evidence is required. In this study, we systematically estimated the incidence rate of anaphylaxis in response to BVA. Methods: We searched eight databases (MEDLINE (Pubmed), EMBASE, Cochrane Central Register of Controlled, KISS, KMBASE, Koreamed, OASIS, and NDSL) and systematically reviewed the articles that met the inclusion/exclusion criteria. Results: Among 225 potentially relevant articles, 49 were selected for this study. The overall incidence rate of anaphylaxis in response to BVA was 0.045% (95% CI 0.028–0.062). Women (0.083%, 95% CI 0.010–0.157) showed a higher incidence rate than men (0.019%, 95% CI −0.018 to 0.055), while the incidence for patients who had a skin test conducted (0.041%, 95% CI 0.011–0.072) was not significantly different compared to that obtained for patients for which there was no information about a skin test (0.047%, 95% CI 0.026–0.067). The publication year affected the incidence rate: it was highest before 1999 (1.099%, 95% CI −1.043 to 3.241), lower between 2000 and 2009 (0.049%, 95% CI 0.025–0.073), and lowest between 2010 and 2021 (0.037% 95% CI 0.014–0.060). Conclusions: In this study, we provide reference data about risk size and factors of BVA-related anaphylaxis, which is essentially required for BVA application in clinics. |
format | Online Article Text |
id | pubmed-9028116 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90281162022-04-23 Incidence Rate of Bee Venom Acupuncture Related Anaphylaxis: A Systematic Review Ko, Seong-Hwan Oh, Hyeon-Muk Kwon, Do-Young Yang, Jae-Eun Kim, Byung-Jun Ha, Hyun-Ju Lim, Eun-Jin Oh, Min-Seok Son, Chang-Gue Lee, Eun-Jung Toxins (Basel) Systematic Review Background: Bee venom acupuncture (BVA) is an effective treatment method for various diseases. Bee venom, however, can cause adverse effects, even rarely including life-threatening anaphylaxis, so safety-related evidence is required. In this study, we systematically estimated the incidence rate of anaphylaxis in response to BVA. Methods: We searched eight databases (MEDLINE (Pubmed), EMBASE, Cochrane Central Register of Controlled, KISS, KMBASE, Koreamed, OASIS, and NDSL) and systematically reviewed the articles that met the inclusion/exclusion criteria. Results: Among 225 potentially relevant articles, 49 were selected for this study. The overall incidence rate of anaphylaxis in response to BVA was 0.045% (95% CI 0.028–0.062). Women (0.083%, 95% CI 0.010–0.157) showed a higher incidence rate than men (0.019%, 95% CI −0.018 to 0.055), while the incidence for patients who had a skin test conducted (0.041%, 95% CI 0.011–0.072) was not significantly different compared to that obtained for patients for which there was no information about a skin test (0.047%, 95% CI 0.026–0.067). The publication year affected the incidence rate: it was highest before 1999 (1.099%, 95% CI −1.043 to 3.241), lower between 2000 and 2009 (0.049%, 95% CI 0.025–0.073), and lowest between 2010 and 2021 (0.037% 95% CI 0.014–0.060). Conclusions: In this study, we provide reference data about risk size and factors of BVA-related anaphylaxis, which is essentially required for BVA application in clinics. MDPI 2022-03-26 /pmc/articles/PMC9028116/ /pubmed/35448847 http://dx.doi.org/10.3390/toxins14040238 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Ko, Seong-Hwan Oh, Hyeon-Muk Kwon, Do-Young Yang, Jae-Eun Kim, Byung-Jun Ha, Hyun-Ju Lim, Eun-Jin Oh, Min-Seok Son, Chang-Gue Lee, Eun-Jung Incidence Rate of Bee Venom Acupuncture Related Anaphylaxis: A Systematic Review |
title | Incidence Rate of Bee Venom Acupuncture Related Anaphylaxis: A Systematic Review |
title_full | Incidence Rate of Bee Venom Acupuncture Related Anaphylaxis: A Systematic Review |
title_fullStr | Incidence Rate of Bee Venom Acupuncture Related Anaphylaxis: A Systematic Review |
title_full_unstemmed | Incidence Rate of Bee Venom Acupuncture Related Anaphylaxis: A Systematic Review |
title_short | Incidence Rate of Bee Venom Acupuncture Related Anaphylaxis: A Systematic Review |
title_sort | incidence rate of bee venom acupuncture related anaphylaxis: a systematic review |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028116/ https://www.ncbi.nlm.nih.gov/pubmed/35448847 http://dx.doi.org/10.3390/toxins14040238 |
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