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Incidence Rate of Bee Venom Acupuncture Related Anaphylaxis: A Systematic Review

Background: Bee venom acupuncture (BVA) is an effective treatment method for various diseases. Bee venom, however, can cause adverse effects, even rarely including life-threatening anaphylaxis, so safety-related evidence is required. In this study, we systematically estimated the incidence rate of a...

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Autores principales: Ko, Seong-Hwan, Oh, Hyeon-Muk, Kwon, Do-Young, Yang, Jae-Eun, Kim, Byung-Jun, Ha, Hyun-Ju, Lim, Eun-Jin, Oh, Min-Seok, Son, Chang-Gue, Lee, Eun-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028116/
https://www.ncbi.nlm.nih.gov/pubmed/35448847
http://dx.doi.org/10.3390/toxins14040238
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author Ko, Seong-Hwan
Oh, Hyeon-Muk
Kwon, Do-Young
Yang, Jae-Eun
Kim, Byung-Jun
Ha, Hyun-Ju
Lim, Eun-Jin
Oh, Min-Seok
Son, Chang-Gue
Lee, Eun-Jung
author_facet Ko, Seong-Hwan
Oh, Hyeon-Muk
Kwon, Do-Young
Yang, Jae-Eun
Kim, Byung-Jun
Ha, Hyun-Ju
Lim, Eun-Jin
Oh, Min-Seok
Son, Chang-Gue
Lee, Eun-Jung
author_sort Ko, Seong-Hwan
collection PubMed
description Background: Bee venom acupuncture (BVA) is an effective treatment method for various diseases. Bee venom, however, can cause adverse effects, even rarely including life-threatening anaphylaxis, so safety-related evidence is required. In this study, we systematically estimated the incidence rate of anaphylaxis in response to BVA. Methods: We searched eight databases (MEDLINE (Pubmed), EMBASE, Cochrane Central Register of Controlled, KISS, KMBASE, Koreamed, OASIS, and NDSL) and systematically reviewed the articles that met the inclusion/exclusion criteria. Results: Among 225 potentially relevant articles, 49 were selected for this study. The overall incidence rate of anaphylaxis in response to BVA was 0.045% (95% CI 0.028–0.062). Women (0.083%, 95% CI 0.010–0.157) showed a higher incidence rate than men (0.019%, 95% CI −0.018 to 0.055), while the incidence for patients who had a skin test conducted (0.041%, 95% CI 0.011–0.072) was not significantly different compared to that obtained for patients for which there was no information about a skin test (0.047%, 95% CI 0.026–0.067). The publication year affected the incidence rate: it was highest before 1999 (1.099%, 95% CI −1.043 to 3.241), lower between 2000 and 2009 (0.049%, 95% CI 0.025–0.073), and lowest between 2010 and 2021 (0.037% 95% CI 0.014–0.060). Conclusions: In this study, we provide reference data about risk size and factors of BVA-related anaphylaxis, which is essentially required for BVA application in clinics.
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spelling pubmed-90281162022-04-23 Incidence Rate of Bee Venom Acupuncture Related Anaphylaxis: A Systematic Review Ko, Seong-Hwan Oh, Hyeon-Muk Kwon, Do-Young Yang, Jae-Eun Kim, Byung-Jun Ha, Hyun-Ju Lim, Eun-Jin Oh, Min-Seok Son, Chang-Gue Lee, Eun-Jung Toxins (Basel) Systematic Review Background: Bee venom acupuncture (BVA) is an effective treatment method for various diseases. Bee venom, however, can cause adverse effects, even rarely including life-threatening anaphylaxis, so safety-related evidence is required. In this study, we systematically estimated the incidence rate of anaphylaxis in response to BVA. Methods: We searched eight databases (MEDLINE (Pubmed), EMBASE, Cochrane Central Register of Controlled, KISS, KMBASE, Koreamed, OASIS, and NDSL) and systematically reviewed the articles that met the inclusion/exclusion criteria. Results: Among 225 potentially relevant articles, 49 were selected for this study. The overall incidence rate of anaphylaxis in response to BVA was 0.045% (95% CI 0.028–0.062). Women (0.083%, 95% CI 0.010–0.157) showed a higher incidence rate than men (0.019%, 95% CI −0.018 to 0.055), while the incidence for patients who had a skin test conducted (0.041%, 95% CI 0.011–0.072) was not significantly different compared to that obtained for patients for which there was no information about a skin test (0.047%, 95% CI 0.026–0.067). The publication year affected the incidence rate: it was highest before 1999 (1.099%, 95% CI −1.043 to 3.241), lower between 2000 and 2009 (0.049%, 95% CI 0.025–0.073), and lowest between 2010 and 2021 (0.037% 95% CI 0.014–0.060). Conclusions: In this study, we provide reference data about risk size and factors of BVA-related anaphylaxis, which is essentially required for BVA application in clinics. MDPI 2022-03-26 /pmc/articles/PMC9028116/ /pubmed/35448847 http://dx.doi.org/10.3390/toxins14040238 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Ko, Seong-Hwan
Oh, Hyeon-Muk
Kwon, Do-Young
Yang, Jae-Eun
Kim, Byung-Jun
Ha, Hyun-Ju
Lim, Eun-Jin
Oh, Min-Seok
Son, Chang-Gue
Lee, Eun-Jung
Incidence Rate of Bee Venom Acupuncture Related Anaphylaxis: A Systematic Review
title Incidence Rate of Bee Venom Acupuncture Related Anaphylaxis: A Systematic Review
title_full Incidence Rate of Bee Venom Acupuncture Related Anaphylaxis: A Systematic Review
title_fullStr Incidence Rate of Bee Venom Acupuncture Related Anaphylaxis: A Systematic Review
title_full_unstemmed Incidence Rate of Bee Venom Acupuncture Related Anaphylaxis: A Systematic Review
title_short Incidence Rate of Bee Venom Acupuncture Related Anaphylaxis: A Systematic Review
title_sort incidence rate of bee venom acupuncture related anaphylaxis: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028116/
https://www.ncbi.nlm.nih.gov/pubmed/35448847
http://dx.doi.org/10.3390/toxins14040238
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