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Epidemiology of the Epstein–Barr Virus in Autoimmune Inflammatory Rheumatic Diseases in Northern Brazil

The present study aimed to describe the seroprevalence infection, Epstein-Barr virus (EBV) genotypes, relate the infection’s profile with the epidemiological and corticotherapy data of patients with Autoimmune inflammatory rheumatic diseases (AIRD). A cross-sectional study was carried out with 139 i...

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Autores principales: França, Samires Avelino de Souza, Viana, Julimar Benedita Gomes de Oliveira, Góes, Hilda Carla Azevedo, Fonseca, Ricardo Roberto de Souza, Laurentino, Rogério Valois, Costa, Igor Brasil, Oliveira-Filho, Aldemir Branco, Machado, Luiz Fernando Almeida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028150/
https://www.ncbi.nlm.nih.gov/pubmed/35458425
http://dx.doi.org/10.3390/v14040694
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author França, Samires Avelino de Souza
Viana, Julimar Benedita Gomes de Oliveira
Góes, Hilda Carla Azevedo
Fonseca, Ricardo Roberto de Souza
Laurentino, Rogério Valois
Costa, Igor Brasil
Oliveira-Filho, Aldemir Branco
Machado, Luiz Fernando Almeida
author_facet França, Samires Avelino de Souza
Viana, Julimar Benedita Gomes de Oliveira
Góes, Hilda Carla Azevedo
Fonseca, Ricardo Roberto de Souza
Laurentino, Rogério Valois
Costa, Igor Brasil
Oliveira-Filho, Aldemir Branco
Machado, Luiz Fernando Almeida
author_sort França, Samires Avelino de Souza
collection PubMed
description The present study aimed to describe the seroprevalence infection, Epstein-Barr virus (EBV) genotypes, relate the infection’s profile with the epidemiological and corticotherapy data of patients with Autoimmune inflammatory rheumatic diseases (AIRD). A cross-sectional study was carried out with 139 individuals, 92 with systemic lupus erythematosus (SLE), 27 with rheumatoid arthritis (RA) and 20 with other autoimmune diseases, who were undergoing clinical follow-up in Brazil. Serological tests for the detection of EBV anti-VCA IgM and IgG antibodies, as well as the amplification of a segment of the EBV EBNA-3c gene by conventional PCR were performed to identify the infection and the viral subtype. The Epstein–Barr nuclear antigen 3 (EBNA3C) gene participates of maintenance of viral latency and infected B-lymphocytes immortalization by unclear signaling cascades. The association of active/latent EBV infection with EBV infection profile was assessed by Fisher’s exact test and multiple logistic regression. The seroprevalence of EBV anti-VCA IgG was 100%, while that of anti-VCA IgM was 1.43% (2/139). Active-phase infection was confirmed by the presence of EBV DNA in 40.29% of the population evaluated (56/139), with 45.65% (42/92) in SLE, 25.92% (7/27) in the RA and in 35% (7/20) in other autoimmune diseases. It was observed that individuals with SLE had a higher prevalence of active/lytic EBV infection and that oral corticosteroid therapy at a dose lower than 20 mg/day increased the risk of EBV activity by up to 11 times. Only the presence of EBV-1 was identified. Thus, EBV lytic infection was higher in individuals with SLE when compared to other autoimmune diseases with rheumatologic involvement and the lytic activity of the virus precedes corticosteroid-induced immunosuppression.
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spelling pubmed-90281502022-04-23 Epidemiology of the Epstein–Barr Virus in Autoimmune Inflammatory Rheumatic Diseases in Northern Brazil França, Samires Avelino de Souza Viana, Julimar Benedita Gomes de Oliveira Góes, Hilda Carla Azevedo Fonseca, Ricardo Roberto de Souza Laurentino, Rogério Valois Costa, Igor Brasil Oliveira-Filho, Aldemir Branco Machado, Luiz Fernando Almeida Viruses Brief Report The present study aimed to describe the seroprevalence infection, Epstein-Barr virus (EBV) genotypes, relate the infection’s profile with the epidemiological and corticotherapy data of patients with Autoimmune inflammatory rheumatic diseases (AIRD). A cross-sectional study was carried out with 139 individuals, 92 with systemic lupus erythematosus (SLE), 27 with rheumatoid arthritis (RA) and 20 with other autoimmune diseases, who were undergoing clinical follow-up in Brazil. Serological tests for the detection of EBV anti-VCA IgM and IgG antibodies, as well as the amplification of a segment of the EBV EBNA-3c gene by conventional PCR were performed to identify the infection and the viral subtype. The Epstein–Barr nuclear antigen 3 (EBNA3C) gene participates of maintenance of viral latency and infected B-lymphocytes immortalization by unclear signaling cascades. The association of active/latent EBV infection with EBV infection profile was assessed by Fisher’s exact test and multiple logistic regression. The seroprevalence of EBV anti-VCA IgG was 100%, while that of anti-VCA IgM was 1.43% (2/139). Active-phase infection was confirmed by the presence of EBV DNA in 40.29% of the population evaluated (56/139), with 45.65% (42/92) in SLE, 25.92% (7/27) in the RA and in 35% (7/20) in other autoimmune diseases. It was observed that individuals with SLE had a higher prevalence of active/lytic EBV infection and that oral corticosteroid therapy at a dose lower than 20 mg/day increased the risk of EBV activity by up to 11 times. Only the presence of EBV-1 was identified. Thus, EBV lytic infection was higher in individuals with SLE when compared to other autoimmune diseases with rheumatologic involvement and the lytic activity of the virus precedes corticosteroid-induced immunosuppression. MDPI 2022-03-27 /pmc/articles/PMC9028150/ /pubmed/35458425 http://dx.doi.org/10.3390/v14040694 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
França, Samires Avelino de Souza
Viana, Julimar Benedita Gomes de Oliveira
Góes, Hilda Carla Azevedo
Fonseca, Ricardo Roberto de Souza
Laurentino, Rogério Valois
Costa, Igor Brasil
Oliveira-Filho, Aldemir Branco
Machado, Luiz Fernando Almeida
Epidemiology of the Epstein–Barr Virus in Autoimmune Inflammatory Rheumatic Diseases in Northern Brazil
title Epidemiology of the Epstein–Barr Virus in Autoimmune Inflammatory Rheumatic Diseases in Northern Brazil
title_full Epidemiology of the Epstein–Barr Virus in Autoimmune Inflammatory Rheumatic Diseases in Northern Brazil
title_fullStr Epidemiology of the Epstein–Barr Virus in Autoimmune Inflammatory Rheumatic Diseases in Northern Brazil
title_full_unstemmed Epidemiology of the Epstein–Barr Virus in Autoimmune Inflammatory Rheumatic Diseases in Northern Brazil
title_short Epidemiology of the Epstein–Barr Virus in Autoimmune Inflammatory Rheumatic Diseases in Northern Brazil
title_sort epidemiology of the epstein–barr virus in autoimmune inflammatory rheumatic diseases in northern brazil
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028150/
https://www.ncbi.nlm.nih.gov/pubmed/35458425
http://dx.doi.org/10.3390/v14040694
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