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Impacts of NaHCO(3) on β-Lactam Binding to PBP2a Protein Variants Associated with the NaHCO(3)-Responsive versus NaHCO(3)-Non-Responsive Phenotypes

Methicillin-resistant Staphylococcus aureus (MRSA) regulates resistance to β-lactams via preferential production of an alternative penicillin-binding protein (PBP), PBP2a. PBP2a binds many β-lactam antibiotics with less affinity than PBPs which are predominant in methicillin-susceptible (MSSA) strai...

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Detalles Bibliográficos
Autores principales:	Ersoy, Selvi C., Chan, Liana C., Yeaman, Michael R., Chambers, Henry F., Proctor, Richard A., Ludwig, Kevin C., Schneider, Tanja, Manna, Adhar C., Cheung, Ambrose, Bayer, Arnold S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028190/ https://www.ncbi.nlm.nih.gov/pubmed/35453214 http://dx.doi.org/10.3390/antibiotics11040462

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