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The Role of the Adipokine Resistin in the Pathogenesis and Progression of Epithelial Ovarian Cancer

Obesity is a civilization disease associated with an increased risk of developing cardiovascular diseases, diabetes, and some malignancies. The results concerning the relationship between obesity and epithelial ovarian cancer (EOC) are inconclusive. The higher incidence of neoplasms in obese subject...

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Autores principales: Parafiniuk, Klaudia, Skiba, Wiktoria, Pawłowska, Anna, Suszczyk, Dorota, Maciejczyk, Aleksandra, Wertel, Iwona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028191/
https://www.ncbi.nlm.nih.gov/pubmed/35453670
http://dx.doi.org/10.3390/biomedicines10040920
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author Parafiniuk, Klaudia
Skiba, Wiktoria
Pawłowska, Anna
Suszczyk, Dorota
Maciejczyk, Aleksandra
Wertel, Iwona
author_facet Parafiniuk, Klaudia
Skiba, Wiktoria
Pawłowska, Anna
Suszczyk, Dorota
Maciejczyk, Aleksandra
Wertel, Iwona
author_sort Parafiniuk, Klaudia
collection PubMed
description Obesity is a civilization disease associated with an increased risk of developing cardiovascular diseases, diabetes, and some malignancies. The results concerning the relationship between obesity and epithelial ovarian cancer (EOC) are inconclusive. The higher incidence of neoplasms in obese subjects has led to the development of the adipokine hypothesis. Omental adipocyte cells interact with cancer cells, promoting their migration and metastasis via the secretion of adipokines, growth factors, and hormones. One of the adipokines is resistin. It was shown in vitro that resistin stimulates the growth and differentiation of ovarian cancer cells. Moreover, it increases the level of angiogenesis factors, e.g., matrix metalloproteinase 2 (MMP-2) and vascular epithelial growth factor (VEGF). Additionally, resistin induces epithelial–mesenchymal transition (EMT) and stemness in EOC cell lines. A positive correlation has been shown between a higher level of resistin expression and the stage of histological differentiation of EOC or the occurrence of lymph node metastases. In addition, the overexpression of resistin has been found to act as an independent factor determining disease-free survival as well as overall survival in EOC patients. Growing evidence supports the finding that resistin plays an important role in some mechanisms leading to the progression of EOC, though this issue still requires further research.
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spelling pubmed-90281912022-04-23 The Role of the Adipokine Resistin in the Pathogenesis and Progression of Epithelial Ovarian Cancer Parafiniuk, Klaudia Skiba, Wiktoria Pawłowska, Anna Suszczyk, Dorota Maciejczyk, Aleksandra Wertel, Iwona Biomedicines Review Obesity is a civilization disease associated with an increased risk of developing cardiovascular diseases, diabetes, and some malignancies. The results concerning the relationship between obesity and epithelial ovarian cancer (EOC) are inconclusive. The higher incidence of neoplasms in obese subjects has led to the development of the adipokine hypothesis. Omental adipocyte cells interact with cancer cells, promoting their migration and metastasis via the secretion of adipokines, growth factors, and hormones. One of the adipokines is resistin. It was shown in vitro that resistin stimulates the growth and differentiation of ovarian cancer cells. Moreover, it increases the level of angiogenesis factors, e.g., matrix metalloproteinase 2 (MMP-2) and vascular epithelial growth factor (VEGF). Additionally, resistin induces epithelial–mesenchymal transition (EMT) and stemness in EOC cell lines. A positive correlation has been shown between a higher level of resistin expression and the stage of histological differentiation of EOC or the occurrence of lymph node metastases. In addition, the overexpression of resistin has been found to act as an independent factor determining disease-free survival as well as overall survival in EOC patients. Growing evidence supports the finding that resistin plays an important role in some mechanisms leading to the progression of EOC, though this issue still requires further research. MDPI 2022-04-16 /pmc/articles/PMC9028191/ /pubmed/35453670 http://dx.doi.org/10.3390/biomedicines10040920 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Parafiniuk, Klaudia
Skiba, Wiktoria
Pawłowska, Anna
Suszczyk, Dorota
Maciejczyk, Aleksandra
Wertel, Iwona
The Role of the Adipokine Resistin in the Pathogenesis and Progression of Epithelial Ovarian Cancer
title The Role of the Adipokine Resistin in the Pathogenesis and Progression of Epithelial Ovarian Cancer
title_full The Role of the Adipokine Resistin in the Pathogenesis and Progression of Epithelial Ovarian Cancer
title_fullStr The Role of the Adipokine Resistin in the Pathogenesis and Progression of Epithelial Ovarian Cancer
title_full_unstemmed The Role of the Adipokine Resistin in the Pathogenesis and Progression of Epithelial Ovarian Cancer
title_short The Role of the Adipokine Resistin in the Pathogenesis and Progression of Epithelial Ovarian Cancer
title_sort role of the adipokine resistin in the pathogenesis and progression of epithelial ovarian cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028191/
https://www.ncbi.nlm.nih.gov/pubmed/35453670
http://dx.doi.org/10.3390/biomedicines10040920
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