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Static and Dynamic Biomaterial Engineering for Cell Modulation
In the biological microenvironment, cells are surrounded by an extracellular matrix (ECM), with which they dynamically interact during various biological processes. Specifically, the physical and chemical properties of the ECM work cooperatively to influence the behavior and fate of cells directly a...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028203/ https://www.ncbi.nlm.nih.gov/pubmed/35458085 http://dx.doi.org/10.3390/nano12081377 |
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author | Park, Hyung-Joon Hong, Hyunsik Thangam, Ramar Song, Min-Gyo Kim, Ju-Eun Jo, Eun-Hae Jang, Yun-Jeong Choi, Won-Hyoung Lee, Min-Young Kang, Heemin Lee, Kyu-Back |
author_facet | Park, Hyung-Joon Hong, Hyunsik Thangam, Ramar Song, Min-Gyo Kim, Ju-Eun Jo, Eun-Hae Jang, Yun-Jeong Choi, Won-Hyoung Lee, Min-Young Kang, Heemin Lee, Kyu-Back |
author_sort | Park, Hyung-Joon |
collection | PubMed |
description | In the biological microenvironment, cells are surrounded by an extracellular matrix (ECM), with which they dynamically interact during various biological processes. Specifically, the physical and chemical properties of the ECM work cooperatively to influence the behavior and fate of cells directly and indirectly, which invokes various physiological responses in the body. Hence, efficient strategies to modulate cellular responses for a specific purpose have become important for various scientific fields such as biology, pharmacy, and medicine. Among many approaches, the utilization of biomaterials has been studied the most because they can be meticulously engineered to mimic cellular modulatory behavior. For such careful engineering, studies on physical modulation (e.g., ECM topography, stiffness, and wettability) and chemical manipulation (e.g., composition and soluble and surface biosignals) have been actively conducted. At present, the scope of research is being shifted from static (considering only the initial environment and the effects of each element) to biomimetic dynamic (including the concepts of time and gradient) modulation in both physical and chemical manipulations. This review provides an overall perspective on how the static and dynamic biomaterials are actively engineered to modulate targeted cellular responses while highlighting the importance and advance from static modulation to biomimetic dynamic modulation for biomedical applications. |
format | Online Article Text |
id | pubmed-9028203 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90282032022-04-23 Static and Dynamic Biomaterial Engineering for Cell Modulation Park, Hyung-Joon Hong, Hyunsik Thangam, Ramar Song, Min-Gyo Kim, Ju-Eun Jo, Eun-Hae Jang, Yun-Jeong Choi, Won-Hyoung Lee, Min-Young Kang, Heemin Lee, Kyu-Back Nanomaterials (Basel) Review In the biological microenvironment, cells are surrounded by an extracellular matrix (ECM), with which they dynamically interact during various biological processes. Specifically, the physical and chemical properties of the ECM work cooperatively to influence the behavior and fate of cells directly and indirectly, which invokes various physiological responses in the body. Hence, efficient strategies to modulate cellular responses for a specific purpose have become important for various scientific fields such as biology, pharmacy, and medicine. Among many approaches, the utilization of biomaterials has been studied the most because they can be meticulously engineered to mimic cellular modulatory behavior. For such careful engineering, studies on physical modulation (e.g., ECM topography, stiffness, and wettability) and chemical manipulation (e.g., composition and soluble and surface biosignals) have been actively conducted. At present, the scope of research is being shifted from static (considering only the initial environment and the effects of each element) to biomimetic dynamic (including the concepts of time and gradient) modulation in both physical and chemical manipulations. This review provides an overall perspective on how the static and dynamic biomaterials are actively engineered to modulate targeted cellular responses while highlighting the importance and advance from static modulation to biomimetic dynamic modulation for biomedical applications. MDPI 2022-04-17 /pmc/articles/PMC9028203/ /pubmed/35458085 http://dx.doi.org/10.3390/nano12081377 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Park, Hyung-Joon Hong, Hyunsik Thangam, Ramar Song, Min-Gyo Kim, Ju-Eun Jo, Eun-Hae Jang, Yun-Jeong Choi, Won-Hyoung Lee, Min-Young Kang, Heemin Lee, Kyu-Back Static and Dynamic Biomaterial Engineering for Cell Modulation |
title | Static and Dynamic Biomaterial Engineering for Cell Modulation |
title_full | Static and Dynamic Biomaterial Engineering for Cell Modulation |
title_fullStr | Static and Dynamic Biomaterial Engineering for Cell Modulation |
title_full_unstemmed | Static and Dynamic Biomaterial Engineering for Cell Modulation |
title_short | Static and Dynamic Biomaterial Engineering for Cell Modulation |
title_sort | static and dynamic biomaterial engineering for cell modulation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028203/ https://www.ncbi.nlm.nih.gov/pubmed/35458085 http://dx.doi.org/10.3390/nano12081377 |
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