Cargando…
Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry
Patterned surfaces can enhance the sensitivity of laser desorption ionization mass spectrometry by segregating and concentrating analytes, but their fabrication can be challenging. Here, a simple method to fabricate substrates patterned with micrometer‐scale wells that yield more accurate and sensit...
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028217/ https://www.ncbi.nlm.nih.gov/pubmed/35045587 http://dx.doi.org/10.1002/adma.202108194 |
| _version_ | 1784691561156575232 |
|---|---|
| author | Xu, Linfeng Li, Xiangpeng Li, Wenzong Chang, Kai‐chun Yang, Hyunjun Tao, Nannan Zhang, Pengfei Payne, Emory M. Modavi, Cyrus Humphries, Jacqueline Lu, Chia‐Wei Abate, Adam R. |
| author_facet | Xu, Linfeng Li, Xiangpeng Li, Wenzong Chang, Kai‐chun Yang, Hyunjun Tao, Nannan Zhang, Pengfei Payne, Emory M. Modavi, Cyrus Humphries, Jacqueline Lu, Chia‐Wei Abate, Adam R. |
| author_sort | Xu, Linfeng |
| collection | PubMed |
| description | Patterned surfaces can enhance the sensitivity of laser desorption ionization mass spectrometry by segregating and concentrating analytes, but their fabrication can be challenging. Here, a simple method to fabricate substrates patterned with micrometer‐scale wells that yield more accurate and sensitive mass spectrometry measurements compared to flat surfaces is described. The wells can also concentrate and localize cells and beads for cell‐based assays. |
| format | Online Article Text |
| id | pubmed-9028217 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-90282172022-04-25 Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry Xu, Linfeng Li, Xiangpeng Li, Wenzong Chang, Kai‐chun Yang, Hyunjun Tao, Nannan Zhang, Pengfei Payne, Emory M. Modavi, Cyrus Humphries, Jacqueline Lu, Chia‐Wei Abate, Adam R. Adv Mater Research Articles Patterned surfaces can enhance the sensitivity of laser desorption ionization mass spectrometry by segregating and concentrating analytes, but their fabrication can be challenging. Here, a simple method to fabricate substrates patterned with micrometer‐scale wells that yield more accurate and sensitive mass spectrometry measurements compared to flat surfaces is described. The wells can also concentrate and localize cells and beads for cell‐based assays. John Wiley and Sons Inc. 2022-02-10 2022-03-24 /pmc/articles/PMC9028217/ /pubmed/35045587 http://dx.doi.org/10.1002/adma.202108194 Text en © 2022 The Authors. Advanced Materials published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Research Articles Xu, Linfeng Li, Xiangpeng Li, Wenzong Chang, Kai‐chun Yang, Hyunjun Tao, Nannan Zhang, Pengfei Payne, Emory M. Modavi, Cyrus Humphries, Jacqueline Lu, Chia‐Wei Abate, Adam R. Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry |
| title | Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry |
| title_full | Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry |
| title_fullStr | Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry |
| title_full_unstemmed | Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry |
| title_short | Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry |
| title_sort | microbowls with controlled concavity for accurate microscale mass spectrometry |
| topic | Research Articles |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028217/ https://www.ncbi.nlm.nih.gov/pubmed/35045587 http://dx.doi.org/10.1002/adma.202108194 |
| work_keys_str_mv | AT xulinfeng microbowlswithcontrolledconcavityforaccuratemicroscalemassspectrometry AT lixiangpeng microbowlswithcontrolledconcavityforaccuratemicroscalemassspectrometry AT liwenzong microbowlswithcontrolledconcavityforaccuratemicroscalemassspectrometry AT changkaichun microbowlswithcontrolledconcavityforaccuratemicroscalemassspectrometry AT yanghyunjun microbowlswithcontrolledconcavityforaccuratemicroscalemassspectrometry AT taonannan microbowlswithcontrolledconcavityforaccuratemicroscalemassspectrometry AT zhangpengfei microbowlswithcontrolledconcavityforaccuratemicroscalemassspectrometry AT payneemorym microbowlswithcontrolledconcavityforaccuratemicroscalemassspectrometry AT modavicyrus microbowlswithcontrolledconcavityforaccuratemicroscalemassspectrometry AT humphriesjacqueline microbowlswithcontrolledconcavityforaccuratemicroscalemassspectrometry AT luchiawei microbowlswithcontrolledconcavityforaccuratemicroscalemassspectrometry AT abateadamr microbowlswithcontrolledconcavityforaccuratemicroscalemassspectrometry |