Effects of “Bacuri” Seed Butter (Platonia insignis Mart.), a Brazilian Amazon Fruit, on Oxidative Stress and Diabetes Mellitus-Related Parameters in STZ-Diabetic Rats

SIMPLE SUMMARY: The abnormal glucose metabolism present in diabetes mellitus causes several complications in different metabolic pathways and different organs. Chronic hyperglycemia promotes an imbalance between ROS production and antioxidant defense, causing oxidative stress, which contributes to damage in the body. The properties of natural products in diabetes mellitus research have been investigated to assist in the treatment. In this study, the effects of 28 days of oral administration of bacuri seed butter (Platonia insignis Mart.) was investigated on blood glucose, HbA1c, and liver and kidney function, as well as antioxidant defense in streptozotocin-induced female rats. Bacuri seed butter presented a positive effect on glycemic control, evidenced by a decrease in the percentage of glycated hemoglobin. Interestingly, the treatment also promoted increased hepatic antioxidant defenses and reduced liver damage, demonstrating a hepatoprotective effect. ABSTRACT: This study aimed to investigate the effects of oral administration of Platonia insignis Mart. (“bacuri”) seed butter (BSB) on oxidative stress and diabetes mellitus-related parameters in streptozotocin-induced (STZ) diabetic rats. Diabetes mellitus was induced in female Wistar rats (180–250 g) by the intraperitoneal administration of STZ (45 mg/kg, b.w). BSB (25, 50, and 100 mg/kg) was administered to animals for four weeks. The effect on weight gain, food intake, blood glucose, glycated hemoglobin, hepatic transaminases, plasma and liver TBARS and MPO activity, erythrocyte SOD activity, non-protein sulfhydryl groups (SH-NP), and histopathology of the liver tissue was investigated. BSB at the dose of 100 mg/kg had a positive effect on the reduction in glycated hemoglobin percentage and increased albumin concentration, as well as decreased ALT and AST levels and increased SH-NP liver levels in treated animals compared to normal control rats. Moreover, BSB had no effects on weight gain, food intake, and fasting glucose. Thus, the BSB presented marked properties in improvement of hepatic antioxidant defenses, which demonstrates BSB as a potential hepatoprotective agent in metabolic disorders.