Cargando…
Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients
In this study, we aimed to quantify LGE and edema at short-tau inversion recovery sequences on cardiac magnetic resonance (CMR) in patients with myocarditis. We retrospectively evaluated CMR examinations performed during the acute phase and at follow-up. Forty-seven patients were eligible for retros...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028348/ https://www.ncbi.nlm.nih.gov/pubmed/35448712 http://dx.doi.org/10.3390/tomography8020078 |
_version_ | 1784691594890313728 |
---|---|
author | Monti, Caterina Beatrice Secchi, Francesco Alì, Marco Carbone, Francesco Saverio Bonomo, Luca Capra, Davide Mobini, Nazanin Di Leo, Giovanni Sardanelli, Francesco |
author_facet | Monti, Caterina Beatrice Secchi, Francesco Alì, Marco Carbone, Francesco Saverio Bonomo, Luca Capra, Davide Mobini, Nazanin Di Leo, Giovanni Sardanelli, Francesco |
author_sort | Monti, Caterina Beatrice |
collection | PubMed |
description | In this study, we aimed to quantify LGE and edema at short-tau inversion recovery sequences on cardiac magnetic resonance (CMR) in patients with myocarditis. We retrospectively evaluated CMR examinations performed during the acute phase and at follow-up. Forty-seven patients were eligible for retrospective LGE assessment, and, among them, twenty-five patients were eligible for edema evaluation. Both groups were paired with age- and sex-matched controls. The median left ventricle LGE was 6.4% (interquartile range 5.0–9.2%) at the acute phase, 4.4% (3.3–7.2%) at follow-up, and 4.3% (3.0–5.3%) in controls, the acute phase being higher than both follow-up and controls (p < 0.001 for both), while follow-up and controls did not differ (p = 0.139). An optimal threshold of 5.0% was obtained for LGE with 87% sensitivity and 48% specificity; the positive likelihood ratio (LR) was 1.67, and the negative LR was 0.27. Edema was 12.8% (9.4–18.1%) at the acute phase, 7.3% (5.5–8.8%) at follow-up, and 6.7% (5.6–8.6%) in controls, the acute phase being higher than both follow-up and controls (both p < 0.001), while follow-up and controls did not differ (p = 0.900). An optimal threshold of 9.5% was obtained for edema with a sensitivity of 76% and a specificity of 88%; the positive LR was 6.33, and the negative LR was 0.27. LGE and edema thresholds are useful in cases of suspected mild myocarditis. |
format | Online Article Text |
id | pubmed-9028348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90283482022-04-23 Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients Monti, Caterina Beatrice Secchi, Francesco Alì, Marco Carbone, Francesco Saverio Bonomo, Luca Capra, Davide Mobini, Nazanin Di Leo, Giovanni Sardanelli, Francesco Tomography Article In this study, we aimed to quantify LGE and edema at short-tau inversion recovery sequences on cardiac magnetic resonance (CMR) in patients with myocarditis. We retrospectively evaluated CMR examinations performed during the acute phase and at follow-up. Forty-seven patients were eligible for retrospective LGE assessment, and, among them, twenty-five patients were eligible for edema evaluation. Both groups were paired with age- and sex-matched controls. The median left ventricle LGE was 6.4% (interquartile range 5.0–9.2%) at the acute phase, 4.4% (3.3–7.2%) at follow-up, and 4.3% (3.0–5.3%) in controls, the acute phase being higher than both follow-up and controls (p < 0.001 for both), while follow-up and controls did not differ (p = 0.139). An optimal threshold of 5.0% was obtained for LGE with 87% sensitivity and 48% specificity; the positive likelihood ratio (LR) was 1.67, and the negative LR was 0.27. Edema was 12.8% (9.4–18.1%) at the acute phase, 7.3% (5.5–8.8%) at follow-up, and 6.7% (5.6–8.6%) in controls, the acute phase being higher than both follow-up and controls (both p < 0.001), while follow-up and controls did not differ (p = 0.900). An optimal threshold of 9.5% was obtained for edema with a sensitivity of 76% and a specificity of 88%; the positive LR was 6.33, and the negative LR was 0.27. LGE and edema thresholds are useful in cases of suspected mild myocarditis. MDPI 2022-04-01 /pmc/articles/PMC9028348/ /pubmed/35448712 http://dx.doi.org/10.3390/tomography8020078 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Monti, Caterina Beatrice Secchi, Francesco Alì, Marco Carbone, Francesco Saverio Bonomo, Luca Capra, Davide Mobini, Nazanin Di Leo, Giovanni Sardanelli, Francesco Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients |
title | Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients |
title_full | Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients |
title_fullStr | Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients |
title_full_unstemmed | Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients |
title_short | Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients |
title_sort | quantitative assessment of late gadolinium enhancement and edema at cardiac magnetic resonance in low-risk myocarditis patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028348/ https://www.ncbi.nlm.nih.gov/pubmed/35448712 http://dx.doi.org/10.3390/tomography8020078 |
work_keys_str_mv | AT monticaterinabeatrice quantitativeassessmentoflategadoliniumenhancementandedemaatcardiacmagneticresonanceinlowriskmyocarditispatients AT secchifrancesco quantitativeassessmentoflategadoliniumenhancementandedemaatcardiacmagneticresonanceinlowriskmyocarditispatients AT alimarco quantitativeassessmentoflategadoliniumenhancementandedemaatcardiacmagneticresonanceinlowriskmyocarditispatients AT carbonefrancescosaverio quantitativeassessmentoflategadoliniumenhancementandedemaatcardiacmagneticresonanceinlowriskmyocarditispatients AT bonomoluca quantitativeassessmentoflategadoliniumenhancementandedemaatcardiacmagneticresonanceinlowriskmyocarditispatients AT capradavide quantitativeassessmentoflategadoliniumenhancementandedemaatcardiacmagneticresonanceinlowriskmyocarditispatients AT mobininazanin quantitativeassessmentoflategadoliniumenhancementandedemaatcardiacmagneticresonanceinlowriskmyocarditispatients AT dileogiovanni quantitativeassessmentoflategadoliniumenhancementandedemaatcardiacmagneticresonanceinlowriskmyocarditispatients AT sardanellifrancesco quantitativeassessmentoflategadoliniumenhancementandedemaatcardiacmagneticresonanceinlowriskmyocarditispatients |