Cargando…

Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients

In this study, we aimed to quantify LGE and edema at short-tau inversion recovery sequences on cardiac magnetic resonance (CMR) in patients with myocarditis. We retrospectively evaluated CMR examinations performed during the acute phase and at follow-up. Forty-seven patients were eligible for retros...

Descripción completa

Detalles Bibliográficos
Autores principales: Monti, Caterina Beatrice, Secchi, Francesco, Alì, Marco, Carbone, Francesco Saverio, Bonomo, Luca, Capra, Davide, Mobini, Nazanin, Di Leo, Giovanni, Sardanelli, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028348/
https://www.ncbi.nlm.nih.gov/pubmed/35448712
http://dx.doi.org/10.3390/tomography8020078
_version_ 1784691594890313728
author Monti, Caterina Beatrice
Secchi, Francesco
Alì, Marco
Carbone, Francesco Saverio
Bonomo, Luca
Capra, Davide
Mobini, Nazanin
Di Leo, Giovanni
Sardanelli, Francesco
author_facet Monti, Caterina Beatrice
Secchi, Francesco
Alì, Marco
Carbone, Francesco Saverio
Bonomo, Luca
Capra, Davide
Mobini, Nazanin
Di Leo, Giovanni
Sardanelli, Francesco
author_sort Monti, Caterina Beatrice
collection PubMed
description In this study, we aimed to quantify LGE and edema at short-tau inversion recovery sequences on cardiac magnetic resonance (CMR) in patients with myocarditis. We retrospectively evaluated CMR examinations performed during the acute phase and at follow-up. Forty-seven patients were eligible for retrospective LGE assessment, and, among them, twenty-five patients were eligible for edema evaluation. Both groups were paired with age- and sex-matched controls. The median left ventricle LGE was 6.4% (interquartile range 5.0–9.2%) at the acute phase, 4.4% (3.3–7.2%) at follow-up, and 4.3% (3.0–5.3%) in controls, the acute phase being higher than both follow-up and controls (p < 0.001 for both), while follow-up and controls did not differ (p = 0.139). An optimal threshold of 5.0% was obtained for LGE with 87% sensitivity and 48% specificity; the positive likelihood ratio (LR) was 1.67, and the negative LR was 0.27. Edema was 12.8% (9.4–18.1%) at the acute phase, 7.3% (5.5–8.8%) at follow-up, and 6.7% (5.6–8.6%) in controls, the acute phase being higher than both follow-up and controls (both p < 0.001), while follow-up and controls did not differ (p = 0.900). An optimal threshold of 9.5% was obtained for edema with a sensitivity of 76% and a specificity of 88%; the positive LR was 6.33, and the negative LR was 0.27. LGE and edema thresholds are useful in cases of suspected mild myocarditis.
format Online
Article
Text
id pubmed-9028348
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-90283482022-04-23 Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients Monti, Caterina Beatrice Secchi, Francesco Alì, Marco Carbone, Francesco Saverio Bonomo, Luca Capra, Davide Mobini, Nazanin Di Leo, Giovanni Sardanelli, Francesco Tomography Article In this study, we aimed to quantify LGE and edema at short-tau inversion recovery sequences on cardiac magnetic resonance (CMR) in patients with myocarditis. We retrospectively evaluated CMR examinations performed during the acute phase and at follow-up. Forty-seven patients were eligible for retrospective LGE assessment, and, among them, twenty-five patients were eligible for edema evaluation. Both groups were paired with age- and sex-matched controls. The median left ventricle LGE was 6.4% (interquartile range 5.0–9.2%) at the acute phase, 4.4% (3.3–7.2%) at follow-up, and 4.3% (3.0–5.3%) in controls, the acute phase being higher than both follow-up and controls (p < 0.001 for both), while follow-up and controls did not differ (p = 0.139). An optimal threshold of 5.0% was obtained for LGE with 87% sensitivity and 48% specificity; the positive likelihood ratio (LR) was 1.67, and the negative LR was 0.27. Edema was 12.8% (9.4–18.1%) at the acute phase, 7.3% (5.5–8.8%) at follow-up, and 6.7% (5.6–8.6%) in controls, the acute phase being higher than both follow-up and controls (both p < 0.001), while follow-up and controls did not differ (p = 0.900). An optimal threshold of 9.5% was obtained for edema with a sensitivity of 76% and a specificity of 88%; the positive LR was 6.33, and the negative LR was 0.27. LGE and edema thresholds are useful in cases of suspected mild myocarditis. MDPI 2022-04-01 /pmc/articles/PMC9028348/ /pubmed/35448712 http://dx.doi.org/10.3390/tomography8020078 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Monti, Caterina Beatrice
Secchi, Francesco
Alì, Marco
Carbone, Francesco Saverio
Bonomo, Luca
Capra, Davide
Mobini, Nazanin
Di Leo, Giovanni
Sardanelli, Francesco
Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients
title Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients
title_full Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients
title_fullStr Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients
title_full_unstemmed Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients
title_short Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients
title_sort quantitative assessment of late gadolinium enhancement and edema at cardiac magnetic resonance in low-risk myocarditis patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028348/
https://www.ncbi.nlm.nih.gov/pubmed/35448712
http://dx.doi.org/10.3390/tomography8020078
work_keys_str_mv AT monticaterinabeatrice quantitativeassessmentoflategadoliniumenhancementandedemaatcardiacmagneticresonanceinlowriskmyocarditispatients
AT secchifrancesco quantitativeassessmentoflategadoliniumenhancementandedemaatcardiacmagneticresonanceinlowriskmyocarditispatients
AT alimarco quantitativeassessmentoflategadoliniumenhancementandedemaatcardiacmagneticresonanceinlowriskmyocarditispatients
AT carbonefrancescosaverio quantitativeassessmentoflategadoliniumenhancementandedemaatcardiacmagneticresonanceinlowriskmyocarditispatients
AT bonomoluca quantitativeassessmentoflategadoliniumenhancementandedemaatcardiacmagneticresonanceinlowriskmyocarditispatients
AT capradavide quantitativeassessmentoflategadoliniumenhancementandedemaatcardiacmagneticresonanceinlowriskmyocarditispatients
AT mobininazanin quantitativeassessmentoflategadoliniumenhancementandedemaatcardiacmagneticresonanceinlowriskmyocarditispatients
AT dileogiovanni quantitativeassessmentoflategadoliniumenhancementandedemaatcardiacmagneticresonanceinlowriskmyocarditispatients
AT sardanellifrancesco quantitativeassessmentoflategadoliniumenhancementandedemaatcardiacmagneticresonanceinlowriskmyocarditispatients