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Derivation and Validation of a Predictive Score for Respiratory Failure Worsening Leading to Secondary Intubation in COVID-19: The CERES Score
Predictive scores assessing the risk of respiratory failure in COVID-19 mostly focused on the prediction of early intubation. A combined assessment of clinical parameters and biomarkers of endotheliopathy could allow to predict late worsening of acute respiratory failure (ARF), subsequently warranti...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028352/ https://www.ncbi.nlm.nih.gov/pubmed/35456266 http://dx.doi.org/10.3390/jcm11082172 |
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author | Gaudet, Alexandre Ghozlan, Benoit Dupont, Annabelle Parmentier-Decrucq, Erika Rosa, Mickael Jeanpierre, Emmanuelle Bayon, Constance Tsicopoulos, Anne Duburcq, Thibault Susen, Sophie Poissy, Julien |
author_facet | Gaudet, Alexandre Ghozlan, Benoit Dupont, Annabelle Parmentier-Decrucq, Erika Rosa, Mickael Jeanpierre, Emmanuelle Bayon, Constance Tsicopoulos, Anne Duburcq, Thibault Susen, Sophie Poissy, Julien |
author_sort | Gaudet, Alexandre |
collection | PubMed |
description | Predictive scores assessing the risk of respiratory failure in COVID-19 mostly focused on the prediction of early intubation. A combined assessment of clinical parameters and biomarkers of endotheliopathy could allow to predict late worsening of acute respiratory failure (ARF), subsequently warranting intubation in COVID-19. Retrospective single-center derivation (n = 92 subjects) and validation cohorts (n = 59 subjects), including severe COVID-19 patients with non-invasive respiratory support, were assessed for at least 48 h following intensive care unit (ICU) admission. We used stepwise regression to construct the COVID endothelial and respiratory failure (CERES) score in a derivation cohort, and secondly assessed its accuracy for the prediction of late ARF worsening, requiring intubation within 15 days following ICU admission in an independent validation cohort. Platelet count, fraction of inspired oxygen, and endocan measured on ICU admission were identified as the top three predictive variables for late ARF worsening and subsequently included in the CERES score. The area under the ROC curve of the CERES score to predict late ARF worsening was calculated in the derivation and validation cohorts at 0.834 and 0.780, respectively. The CERES score is a simple tool with good performances to predict respiratory failure worsening, leading to secondary intubation, in COVID-19 patients. |
format | Online Article Text |
id | pubmed-9028352 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90283522022-04-23 Derivation and Validation of a Predictive Score for Respiratory Failure Worsening Leading to Secondary Intubation in COVID-19: The CERES Score Gaudet, Alexandre Ghozlan, Benoit Dupont, Annabelle Parmentier-Decrucq, Erika Rosa, Mickael Jeanpierre, Emmanuelle Bayon, Constance Tsicopoulos, Anne Duburcq, Thibault Susen, Sophie Poissy, Julien J Clin Med Article Predictive scores assessing the risk of respiratory failure in COVID-19 mostly focused on the prediction of early intubation. A combined assessment of clinical parameters and biomarkers of endotheliopathy could allow to predict late worsening of acute respiratory failure (ARF), subsequently warranting intubation in COVID-19. Retrospective single-center derivation (n = 92 subjects) and validation cohorts (n = 59 subjects), including severe COVID-19 patients with non-invasive respiratory support, were assessed for at least 48 h following intensive care unit (ICU) admission. We used stepwise regression to construct the COVID endothelial and respiratory failure (CERES) score in a derivation cohort, and secondly assessed its accuracy for the prediction of late ARF worsening, requiring intubation within 15 days following ICU admission in an independent validation cohort. Platelet count, fraction of inspired oxygen, and endocan measured on ICU admission were identified as the top three predictive variables for late ARF worsening and subsequently included in the CERES score. The area under the ROC curve of the CERES score to predict late ARF worsening was calculated in the derivation and validation cohorts at 0.834 and 0.780, respectively. The CERES score is a simple tool with good performances to predict respiratory failure worsening, leading to secondary intubation, in COVID-19 patients. MDPI 2022-04-13 /pmc/articles/PMC9028352/ /pubmed/35456266 http://dx.doi.org/10.3390/jcm11082172 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gaudet, Alexandre Ghozlan, Benoit Dupont, Annabelle Parmentier-Decrucq, Erika Rosa, Mickael Jeanpierre, Emmanuelle Bayon, Constance Tsicopoulos, Anne Duburcq, Thibault Susen, Sophie Poissy, Julien Derivation and Validation of a Predictive Score for Respiratory Failure Worsening Leading to Secondary Intubation in COVID-19: The CERES Score |
title | Derivation and Validation of a Predictive Score for Respiratory Failure Worsening Leading to Secondary Intubation in COVID-19: The CERES Score |
title_full | Derivation and Validation of a Predictive Score for Respiratory Failure Worsening Leading to Secondary Intubation in COVID-19: The CERES Score |
title_fullStr | Derivation and Validation of a Predictive Score for Respiratory Failure Worsening Leading to Secondary Intubation in COVID-19: The CERES Score |
title_full_unstemmed | Derivation and Validation of a Predictive Score for Respiratory Failure Worsening Leading to Secondary Intubation in COVID-19: The CERES Score |
title_short | Derivation and Validation of a Predictive Score for Respiratory Failure Worsening Leading to Secondary Intubation in COVID-19: The CERES Score |
title_sort | derivation and validation of a predictive score for respiratory failure worsening leading to secondary intubation in covid-19: the ceres score |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028352/ https://www.ncbi.nlm.nih.gov/pubmed/35456266 http://dx.doi.org/10.3390/jcm11082172 |
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