Cargando…

Effect of Solvents, Stabilizers and the Concentration of Stabilizers on the Physical Properties of Poly(d,l-lactide-co-glycolide) Nanoparticles: Encapsulation, In Vitro Release of Indomethacin and Cytotoxicity against HepG2-Cell

A biocompatible, biodegradable and FDA-approved polymer [Poly lactic-co-glycolic acid (PLGA)] was used to prepare the nanoparticles (NPs) to observe the effect of solvents, stabilizers and their concentrations on the physical properties of the PLGA-NPs, following the encapsulation and in vitro relea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alkholief, Musaed, Kalam, Mohd Abul, Anwer, Md Khalid, Alshamsan, Aws
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028368/ https://www.ncbi.nlm.nih.gov/pubmed/35456705 http://dx.doi.org/10.3390/pharmaceutics14040870

Ejemplares similares

Solubility Measurement and Various Solubility Parameters of Glipizide in Different Neat Solvents
por: Kalam, Mohd Abul, et al.
Publicado: (2020)

Thermoresponsive sol-gel improves ocular bioavailability of Dipivefrin hydrochloride and potentially reduces the elevated intraocular pressure in vivo
por: Alkholief, Musaed, et al.
Publicado: (2020)

Development and Evaluation of Chitosan Nanoparticles for Ocular Delivery of Tedizolid Phosphate
por: Kalam, Mohd Abul, et al.
Publicado: (2022)

Fabrication and Characterization of Tedizolid Phosphate Nanocrystals for Topical Ocular Application: Improved Solubilization and In Vitro Drug Release
por: Kalam, Mohd Abul, et al.
Publicado: (2022)

Employing a PLGA-TPGS based nanoparticle to improve the ocular delivery of Acyclovir
por: Alkholief, Musaed, et al.
Publicado: (2019)

The Design of Anionic Surfactant-Based Amino-Functionalized Mesoporous Silica Nanoparticles and their Application in Transdermal Drug Delivery
por: Almomen, Aliyah, et al.
Publicado: (2020)

Perspectives of Positively Charged Nanocrystals of Tedizolid Phosphate as a Topical Ocular Application in Rabbits
por: Alshememry, Abdullah, et al.
Publicado: (2022)

Facile Hydrophobication of Glutathione-Protected Gold Nanoclusters and Encapsulation into Poly(lactide-co-glycolide) Nanocarriers
por: Alkilany, Alaaldin M., et al.
Publicado: (2019)

Encapsulation of Andrographolide in poly(lactide-co-glycolide) Nanoparticles: Formulation Optimization and in vitro Efficacy Studies
por: Oseni, Bukola A., et al.
Publicado: (2021)

Effect of cryoprotection on particle size stability and preservation of chitosan nanoparticles with and without hyaluronate or alginate coating
por: Almalik, Abdulaziz, et al.
Publicado: (2017)

Topical Application of Linezolid–Loaded Chitosan Nanoparticles for the Treatment of Eye Infections
por: Alkholief, Musaed, et al.
Publicado: (2023)

Topical Sustained-Release Dexamethasone-Loaded Chitosan Nanoparticles: Assessment of Drug Delivery Efficiency in a Rabbit Model of Endotoxin-Induced Uveitis
por: Alkholief, Musaed, et al.
Publicado: (2023)

Stabilizers influence drug–polymer interactions and physicochemical properties of disulfiram-loaded poly-lactide-co-glycolide nanoparticles
por: Hoda, Muddasarul, et al.
Publicado: (2017)

The Design of Poly(lactide-co-glycolide) Nanocarriers for Medical Applications
por: Essa, Divesha, et al.
Publicado: (2020)

A Dual-sensitive Hydrogel Based on Poly(Lactide-co-Glycolide)-Polyethylene Glycol-Poly(Lactide-co-Glycolide) Block Copolymers for 3D Printing
por: Zhou, Yang, et al.
Publicado: (2021)

Antitumor Effect of the Idiotypic Cascade Induced by an Antibody Encapsulated in Poly(d, l‐lactide‐co‐glycolide) Microspheres
por: Ma, Jie, et al.
Publicado: (2001)

Biodegradable membrane of poly(l-lactide acid-dioxanone-glycolide) and stereocomplex poly(lactide) with enhanced crystallization and biocompatibility
por: Fan, Tiantang, et al.
Publicado: (2022)

Mesoporous Silica Nanoparticles Coated with Carboxymethyl Chitosan for 5-Fluorouracil Ocular Delivery: Characterization, In Vitro and In Vivo Studies
por: Alhowyan, Adel Ali, et al.
Publicado: (2023)

Abemaciclib-loaded ethylcellulose based nanosponges for sustained cytotoxicity against MCF-7 and MDA-MB-231 human breast cancer cells lines
por: Anwer, Md. Khalid, et al.
Publicado: (2022)

Imparting Superhydrophobicity to Biodegradable Poly(lactide-co-glycolide) Electrospun Meshes
por: Kaplan, Jonah A., et al.
Publicado: (2014)

Imiquimod-Loaded Chitosan-Decorated Di-Block and Tri-Block Polymeric Nanoparticles Loaded In Situ Gel for the Management of Cervical Cancer
por: Almomen, Aliyah, et al.
Publicado: (2023)

Encapsulation of Low Metronidazole Dose in Poly (D,L-lactide-co-glycolide) (PLGA) Nanoparticles Improves Giardia intestinalis Treatment
por: Madbouly, Neveen Adel, et al.
Publicado: (2020)

Poly(lactide-co-glycolide)/Hydroxyapatite Porous Scaffold with Microchannels for Bone Regeneration
por: Zhang, Ning, et al.
Publicado: (2016)

Microencapsulation of Thymol in Poly(lactide-co-glycolide) (PLGA): Physical and Antibacterial Properties
por: Zhu, Zhu, et al.
Publicado: (2019)

Suggested Procedures for the Reproducible Synthesis of Poly(d,l-lactide-co-glycolide) Nanoparticles Using the Emulsification Solvent Diffusion Platform
por: Haque, Shadabul, et al.
Publicado: (2018)

Influence of Hydroxyapatite Surface Functionalization on Thermal and Biological Properties of Poly(l-Lactide)- and Poly(l-Lactide-co-Glycolide)-Based Composites
por: Gazińska, Małgorzata, et al.
Publicado: (2020)

Double-Walled Poly-(D,L-lactide-co-glycolide) (PLGA) and Poly(L-lactide) (PLLA) Nanoparticles for the Sustained Release of Doxorubicin
por: Cardoso, M. Margarida, et al.
Publicado: (2021)

Preparation of Poly (dl-Lactide-co-Glycolide) Nanoparticles Encapsulated with Periglaucine A and Betulinic Acid for In Vitro Anti-Acanthamoeba and Cytotoxicity Activities
por: Mahboob, Tooba, et al.
Publicado: (2018)

Sustained Release of Lidocaine from Solvent-Free Biodegradable Poly[(d,l)-Lactide-co-Glycolide] (PLGA): In Vitro and In Vivo Study
por: Kau, Yi-Chuan, et al.
Publicado: (2014)

Enhanced antibacterial activity of roxithromycin loaded pegylated poly lactide-co-glycolide nanoparticles
por: Koopaei, Mona Noori, et al.
Publicado: (2012)

Rational Mitomycin Nanocarriers Based on Hydrophobically Functionalized Polyelectrolytes and Poly(lactide-co-glycolide)
por: Lamch, Łukasz, et al.
Publicado: (2022)

Development and validation of a UPLC-MS/MS method for simultaneous detection of doxorubicin and sorafenib in plasma: Application to pharmacokinetic studies in rats
por: Altalal, Alanoud, et al.
Publicado: (2023)

Influence of lactide vs glycolide composition of poly (lactic-co-glycolic acid) polymers on encapsulation of hydrophobic molecules: molecular dynamics and formulation studies
por: Dobhal, Anurag, et al.
Publicado: (2021)

Primary biocompatibility tests of poly(lactide-co-glycolide)-(poly-L-orithine/fucoidan) core–shell nanocarriers
por: Cai, Duanhua, et al.
Publicado: (2018)

Preparation and Characterization of Poly(D,L-Lactide-co-Glycolide) Nanoparticles Containing Ascorbic Acid
por: Stevanović, Magdalena M., et al.
Publicado: (2007)

Poly(d,l-lactide-co-glycolide)–chitosan composite particles for the treatment of lung cancer
por: Arya, Neha, et al.
Publicado: (2015)

Glycosaminoglycan-functionalized poly-lactide-co-glycolide nanoparticles: synthesis, characterization, cytocompatibility, and cellular uptake
por: Lamichhane, Surya P, et al.
Publicado: (2015)

Preparation, characterization, and safety evaluation of poly(lactide-co-glycolide) nanoparticles for protein delivery into macrophages
por: Guedj, Anne-Sophie, et al.
Publicado: (2015)

Preparation, Characterization, and In Vivo Evaluation of Olanzapine Poly(D,L-lactide-co-glycolide) Microspheres
por: D'Souza, Susan, et al.
Publicado: (2013)

Controlled Release of Lysozyme from Double-Walled Poly(Lactide-Co-Glycolide) (PLGA) Microspheres
por: Ansary, Rezaul H., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_q63a5851nbe242lljd8sjvq66b