The Relationship between Cancer and Paraoxonase 1

Extensive research has been carried out to understand and elucidate the mechanisms of paraoxonase 1 (PON1) in the development of diseases including cancer, cardiovascular diseases, neurological diseases, and inflammatory diseases. This review focuses on the relationship between PON1 and cancer. The...

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Detalles Bibliográficos
Autores principales: Medina-Díaz, Irma Martha, Ponce-Ruíz, Néstor, Rojas-García, Aurora Elizabeth, Zambrano-Zargoza, José Francisco, Bernal-Hernández, Yael Y., González-Arias, Cyndia Azucena, Barrón-Vivanco, Briscia S., Herrera-Moreno, José Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028432/
https://www.ncbi.nlm.nih.gov/pubmed/35453382
http://dx.doi.org/10.3390/antiox11040697
Descripción
Sumario:Extensive research has been carried out to understand and elucidate the mechanisms of paraoxonase 1 (PON1) in the development of diseases including cancer, cardiovascular diseases, neurological diseases, and inflammatory diseases. This review focuses on the relationship between PON1 and cancer. The data suggest that PON1, oxidative stress, chronic inflammation, and cancer are closely linked. Certainly, the gene expression of PON1 will remain challenging to study. Therefore, targeting PON1, redox-sensitive pathways, and transcription factors promise prevention and therapy in the development of several diseases, including cancer.

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