The Relationship between Cancer and Paraoxonase 1

Extensive research has been carried out to understand and elucidate the mechanisms of paraoxonase 1 (PON1) in the development of diseases including cancer, cardiovascular diseases, neurological diseases, and inflammatory diseases. This review focuses on the relationship between PON1 and cancer. The...

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Autores principales: Medina-Díaz, Irma Martha, Ponce-Ruíz, Néstor, Rojas-García, Aurora Elizabeth, Zambrano-Zargoza, José Francisco, Bernal-Hernández, Yael Y., González-Arias, Cyndia Azucena, Barrón-Vivanco, Briscia S., Herrera-Moreno, José Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028432/
https://www.ncbi.nlm.nih.gov/pubmed/35453382
http://dx.doi.org/10.3390/antiox11040697
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author Medina-Díaz, Irma Martha
Ponce-Ruíz, Néstor
Rojas-García, Aurora Elizabeth
Zambrano-Zargoza, José Francisco
Bernal-Hernández, Yael Y.
González-Arias, Cyndia Azucena
Barrón-Vivanco, Briscia S.
Herrera-Moreno, José Francisco
author_facet Medina-Díaz, Irma Martha
Ponce-Ruíz, Néstor
Rojas-García, Aurora Elizabeth
Zambrano-Zargoza, José Francisco
Bernal-Hernández, Yael Y.
González-Arias, Cyndia Azucena
Barrón-Vivanco, Briscia S.
Herrera-Moreno, José Francisco
author_sort Medina-Díaz, Irma Martha
collection PubMed
description Extensive research has been carried out to understand and elucidate the mechanisms of paraoxonase 1 (PON1) in the development of diseases including cancer, cardiovascular diseases, neurological diseases, and inflammatory diseases. This review focuses on the relationship between PON1 and cancer. The data suggest that PON1, oxidative stress, chronic inflammation, and cancer are closely linked. Certainly, the gene expression of PON1 will remain challenging to study. Therefore, targeting PON1, redox-sensitive pathways, and transcription factors promise prevention and therapy in the development of several diseases, including cancer.
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spelling pubmed-90284322022-04-23 The Relationship between Cancer and Paraoxonase 1 Medina-Díaz, Irma Martha Ponce-Ruíz, Néstor Rojas-García, Aurora Elizabeth Zambrano-Zargoza, José Francisco Bernal-Hernández, Yael Y. González-Arias, Cyndia Azucena Barrón-Vivanco, Briscia S. Herrera-Moreno, José Francisco Antioxidants (Basel) Review Extensive research has been carried out to understand and elucidate the mechanisms of paraoxonase 1 (PON1) in the development of diseases including cancer, cardiovascular diseases, neurological diseases, and inflammatory diseases. This review focuses on the relationship between PON1 and cancer. The data suggest that PON1, oxidative stress, chronic inflammation, and cancer are closely linked. Certainly, the gene expression of PON1 will remain challenging to study. Therefore, targeting PON1, redox-sensitive pathways, and transcription factors promise prevention and therapy in the development of several diseases, including cancer. MDPI 2022-03-31 /pmc/articles/PMC9028432/ /pubmed/35453382 http://dx.doi.org/10.3390/antiox11040697 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Medina-Díaz, Irma Martha
Ponce-Ruíz, Néstor
Rojas-García, Aurora Elizabeth
Zambrano-Zargoza, José Francisco
Bernal-Hernández, Yael Y.
González-Arias, Cyndia Azucena
Barrón-Vivanco, Briscia S.
Herrera-Moreno, José Francisco
The Relationship between Cancer and Paraoxonase 1
title The Relationship between Cancer and Paraoxonase 1
title_full The Relationship between Cancer and Paraoxonase 1
title_fullStr The Relationship between Cancer and Paraoxonase 1
title_full_unstemmed The Relationship between Cancer and Paraoxonase 1
title_short The Relationship between Cancer and Paraoxonase 1
title_sort relationship between cancer and paraoxonase 1
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028432/
https://www.ncbi.nlm.nih.gov/pubmed/35453382
http://dx.doi.org/10.3390/antiox11040697
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