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Broad-Spectrum Antimicrobial ZnMintPc Encapsulated in Magnetic-Nanocomposites with Graphene Oxide/MWCNTs Based on Bimodal Action of Photodynamic and Photothermal Effects

Microbial diseases have been declared one of the main threats to humanity, which is why, in recent years, great interest has been generated in the development of nanocomposites with antimicrobial capacity. The present work studied two magnetic nanocomposites based on graphene oxide (GO) and multiwal...

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Autores principales: Cuadrado, Coralia Fabiola, Díaz-Barrios, Antonio, Campaña, Kleber Orlando, Romani, Eric Cardona, Quiroz, Francisco, Nardecchia, Stefania, Debut, Alexis, Vizuete, Karla, Niebieskikwiat, Dario, Ávila, Camilo Ernesto, Salazar, Mateo Alejandro, Garzón-Romero, Cristina, Blasco-Zúñiga, Ailín, Rivera, Miryan Rosita, Romero, María Paulina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028436/
https://www.ncbi.nlm.nih.gov/pubmed/35456539
http://dx.doi.org/10.3390/pharmaceutics14040705
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author Cuadrado, Coralia Fabiola
Díaz-Barrios, Antonio
Campaña, Kleber Orlando
Romani, Eric Cardona
Quiroz, Francisco
Nardecchia, Stefania
Debut, Alexis
Vizuete, Karla
Niebieskikwiat, Dario
Ávila, Camilo Ernesto
Salazar, Mateo Alejandro
Garzón-Romero, Cristina
Blasco-Zúñiga, Ailín
Rivera, Miryan Rosita
Romero, María Paulina
author_facet Cuadrado, Coralia Fabiola
Díaz-Barrios, Antonio
Campaña, Kleber Orlando
Romani, Eric Cardona
Quiroz, Francisco
Nardecchia, Stefania
Debut, Alexis
Vizuete, Karla
Niebieskikwiat, Dario
Ávila, Camilo Ernesto
Salazar, Mateo Alejandro
Garzón-Romero, Cristina
Blasco-Zúñiga, Ailín
Rivera, Miryan Rosita
Romero, María Paulina
author_sort Cuadrado, Coralia Fabiola
collection PubMed
description Microbial diseases have been declared one of the main threats to humanity, which is why, in recent years, great interest has been generated in the development of nanocomposites with antimicrobial capacity. The present work studied two magnetic nanocomposites based on graphene oxide (GO) and multiwall carbon nanotubes (MWCNTs). The synthesis of these magnetic nanocomposites consisted of three phases: first, the synthesis of iron magnetic nanoparticles (MNPs), second, the adsorption of the photosensitizer menthol-Zinc phthalocyanine (ZnMintPc) into MWCNTs and GO, and the third phase, encapsulation in poly (N-vinylcaprolactam-co-poly(ethylene glycol diacrylate)) poly (VCL-co-PEGDA) polymer VCL/PEGDA a biocompatible hydrogel, to obtain the magnetic nanocomposites VCL/PEGDA-MNPs-MWCNTs-ZnMintPc and VCL/PEGDA-MNPs-GO-ZnMintPc. In vitro studies were carried out using Escherichia coli and Staphylococcus aureus bacteria and the Candida albicans yeast based on the Photodynamic/Photothermal (PTT/PDT) effect. This research describes the nanocomposites’ optical, morphological, magnetic, and photophysical characteristics and their application as antimicrobial agents. The antimicrobial effect of magnetics nanocomposites was evaluated based on the PDT/PTT effect. For this purpose, doses of 65 mW·cm(−2) with 630 nm light were used. The VCL/PEGDA-MNPs-GO-ZnMintPc nanocomposite eliminated E. coli and S. aureus colonies, while the VCL/PEGDA-MNPs-MWCNTs-ZnMintPc nanocomposite was able to kill the three types of microorganisms. Consequently, the latter is considered a broad-spectrum antimicrobial agent in PDT and PTT.
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spelling pubmed-90284362022-04-23 Broad-Spectrum Antimicrobial ZnMintPc Encapsulated in Magnetic-Nanocomposites with Graphene Oxide/MWCNTs Based on Bimodal Action of Photodynamic and Photothermal Effects Cuadrado, Coralia Fabiola Díaz-Barrios, Antonio Campaña, Kleber Orlando Romani, Eric Cardona Quiroz, Francisco Nardecchia, Stefania Debut, Alexis Vizuete, Karla Niebieskikwiat, Dario Ávila, Camilo Ernesto Salazar, Mateo Alejandro Garzón-Romero, Cristina Blasco-Zúñiga, Ailín Rivera, Miryan Rosita Romero, María Paulina Pharmaceutics Article Microbial diseases have been declared one of the main threats to humanity, which is why, in recent years, great interest has been generated in the development of nanocomposites with antimicrobial capacity. The present work studied two magnetic nanocomposites based on graphene oxide (GO) and multiwall carbon nanotubes (MWCNTs). The synthesis of these magnetic nanocomposites consisted of three phases: first, the synthesis of iron magnetic nanoparticles (MNPs), second, the adsorption of the photosensitizer menthol-Zinc phthalocyanine (ZnMintPc) into MWCNTs and GO, and the third phase, encapsulation in poly (N-vinylcaprolactam-co-poly(ethylene glycol diacrylate)) poly (VCL-co-PEGDA) polymer VCL/PEGDA a biocompatible hydrogel, to obtain the magnetic nanocomposites VCL/PEGDA-MNPs-MWCNTs-ZnMintPc and VCL/PEGDA-MNPs-GO-ZnMintPc. In vitro studies were carried out using Escherichia coli and Staphylococcus aureus bacteria and the Candida albicans yeast based on the Photodynamic/Photothermal (PTT/PDT) effect. This research describes the nanocomposites’ optical, morphological, magnetic, and photophysical characteristics and their application as antimicrobial agents. The antimicrobial effect of magnetics nanocomposites was evaluated based on the PDT/PTT effect. For this purpose, doses of 65 mW·cm(−2) with 630 nm light were used. The VCL/PEGDA-MNPs-GO-ZnMintPc nanocomposite eliminated E. coli and S. aureus colonies, while the VCL/PEGDA-MNPs-MWCNTs-ZnMintPc nanocomposite was able to kill the three types of microorganisms. Consequently, the latter is considered a broad-spectrum antimicrobial agent in PDT and PTT. MDPI 2022-03-26 /pmc/articles/PMC9028436/ /pubmed/35456539 http://dx.doi.org/10.3390/pharmaceutics14040705 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cuadrado, Coralia Fabiola
Díaz-Barrios, Antonio
Campaña, Kleber Orlando
Romani, Eric Cardona
Quiroz, Francisco
Nardecchia, Stefania
Debut, Alexis
Vizuete, Karla
Niebieskikwiat, Dario
Ávila, Camilo Ernesto
Salazar, Mateo Alejandro
Garzón-Romero, Cristina
Blasco-Zúñiga, Ailín
Rivera, Miryan Rosita
Romero, María Paulina
Broad-Spectrum Antimicrobial ZnMintPc Encapsulated in Magnetic-Nanocomposites with Graphene Oxide/MWCNTs Based on Bimodal Action of Photodynamic and Photothermal Effects
title Broad-Spectrum Antimicrobial ZnMintPc Encapsulated in Magnetic-Nanocomposites with Graphene Oxide/MWCNTs Based on Bimodal Action of Photodynamic and Photothermal Effects
title_full Broad-Spectrum Antimicrobial ZnMintPc Encapsulated in Magnetic-Nanocomposites with Graphene Oxide/MWCNTs Based on Bimodal Action of Photodynamic and Photothermal Effects
title_fullStr Broad-Spectrum Antimicrobial ZnMintPc Encapsulated in Magnetic-Nanocomposites with Graphene Oxide/MWCNTs Based on Bimodal Action of Photodynamic and Photothermal Effects
title_full_unstemmed Broad-Spectrum Antimicrobial ZnMintPc Encapsulated in Magnetic-Nanocomposites with Graphene Oxide/MWCNTs Based on Bimodal Action of Photodynamic and Photothermal Effects
title_short Broad-Spectrum Antimicrobial ZnMintPc Encapsulated in Magnetic-Nanocomposites with Graphene Oxide/MWCNTs Based on Bimodal Action of Photodynamic and Photothermal Effects
title_sort broad-spectrum antimicrobial znmintpc encapsulated in magnetic-nanocomposites with graphene oxide/mwcnts based on bimodal action of photodynamic and photothermal effects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028436/
https://www.ncbi.nlm.nih.gov/pubmed/35456539
http://dx.doi.org/10.3390/pharmaceutics14040705
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