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Broad-Spectrum Antimicrobial ZnMintPc Encapsulated in Magnetic-Nanocomposites with Graphene Oxide/MWCNTs Based on Bimodal Action of Photodynamic and Photothermal Effects
Microbial diseases have been declared one of the main threats to humanity, which is why, in recent years, great interest has been generated in the development of nanocomposites with antimicrobial capacity. The present work studied two magnetic nanocomposites based on graphene oxide (GO) and multiwal...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028436/ https://www.ncbi.nlm.nih.gov/pubmed/35456539 http://dx.doi.org/10.3390/pharmaceutics14040705 |
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author | Cuadrado, Coralia Fabiola Díaz-Barrios, Antonio Campaña, Kleber Orlando Romani, Eric Cardona Quiroz, Francisco Nardecchia, Stefania Debut, Alexis Vizuete, Karla Niebieskikwiat, Dario Ávila, Camilo Ernesto Salazar, Mateo Alejandro Garzón-Romero, Cristina Blasco-Zúñiga, Ailín Rivera, Miryan Rosita Romero, María Paulina |
author_facet | Cuadrado, Coralia Fabiola Díaz-Barrios, Antonio Campaña, Kleber Orlando Romani, Eric Cardona Quiroz, Francisco Nardecchia, Stefania Debut, Alexis Vizuete, Karla Niebieskikwiat, Dario Ávila, Camilo Ernesto Salazar, Mateo Alejandro Garzón-Romero, Cristina Blasco-Zúñiga, Ailín Rivera, Miryan Rosita Romero, María Paulina |
author_sort | Cuadrado, Coralia Fabiola |
collection | PubMed |
description | Microbial diseases have been declared one of the main threats to humanity, which is why, in recent years, great interest has been generated in the development of nanocomposites with antimicrobial capacity. The present work studied two magnetic nanocomposites based on graphene oxide (GO) and multiwall carbon nanotubes (MWCNTs). The synthesis of these magnetic nanocomposites consisted of three phases: first, the synthesis of iron magnetic nanoparticles (MNPs), second, the adsorption of the photosensitizer menthol-Zinc phthalocyanine (ZnMintPc) into MWCNTs and GO, and the third phase, encapsulation in poly (N-vinylcaprolactam-co-poly(ethylene glycol diacrylate)) poly (VCL-co-PEGDA) polymer VCL/PEGDA a biocompatible hydrogel, to obtain the magnetic nanocomposites VCL/PEGDA-MNPs-MWCNTs-ZnMintPc and VCL/PEGDA-MNPs-GO-ZnMintPc. In vitro studies were carried out using Escherichia coli and Staphylococcus aureus bacteria and the Candida albicans yeast based on the Photodynamic/Photothermal (PTT/PDT) effect. This research describes the nanocomposites’ optical, morphological, magnetic, and photophysical characteristics and their application as antimicrobial agents. The antimicrobial effect of magnetics nanocomposites was evaluated based on the PDT/PTT effect. For this purpose, doses of 65 mW·cm(−2) with 630 nm light were used. The VCL/PEGDA-MNPs-GO-ZnMintPc nanocomposite eliminated E. coli and S. aureus colonies, while the VCL/PEGDA-MNPs-MWCNTs-ZnMintPc nanocomposite was able to kill the three types of microorganisms. Consequently, the latter is considered a broad-spectrum antimicrobial agent in PDT and PTT. |
format | Online Article Text |
id | pubmed-9028436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90284362022-04-23 Broad-Spectrum Antimicrobial ZnMintPc Encapsulated in Magnetic-Nanocomposites with Graphene Oxide/MWCNTs Based on Bimodal Action of Photodynamic and Photothermal Effects Cuadrado, Coralia Fabiola Díaz-Barrios, Antonio Campaña, Kleber Orlando Romani, Eric Cardona Quiroz, Francisco Nardecchia, Stefania Debut, Alexis Vizuete, Karla Niebieskikwiat, Dario Ávila, Camilo Ernesto Salazar, Mateo Alejandro Garzón-Romero, Cristina Blasco-Zúñiga, Ailín Rivera, Miryan Rosita Romero, María Paulina Pharmaceutics Article Microbial diseases have been declared one of the main threats to humanity, which is why, in recent years, great interest has been generated in the development of nanocomposites with antimicrobial capacity. The present work studied two magnetic nanocomposites based on graphene oxide (GO) and multiwall carbon nanotubes (MWCNTs). The synthesis of these magnetic nanocomposites consisted of three phases: first, the synthesis of iron magnetic nanoparticles (MNPs), second, the adsorption of the photosensitizer menthol-Zinc phthalocyanine (ZnMintPc) into MWCNTs and GO, and the third phase, encapsulation in poly (N-vinylcaprolactam-co-poly(ethylene glycol diacrylate)) poly (VCL-co-PEGDA) polymer VCL/PEGDA a biocompatible hydrogel, to obtain the magnetic nanocomposites VCL/PEGDA-MNPs-MWCNTs-ZnMintPc and VCL/PEGDA-MNPs-GO-ZnMintPc. In vitro studies were carried out using Escherichia coli and Staphylococcus aureus bacteria and the Candida albicans yeast based on the Photodynamic/Photothermal (PTT/PDT) effect. This research describes the nanocomposites’ optical, morphological, magnetic, and photophysical characteristics and their application as antimicrobial agents. The antimicrobial effect of magnetics nanocomposites was evaluated based on the PDT/PTT effect. For this purpose, doses of 65 mW·cm(−2) with 630 nm light were used. The VCL/PEGDA-MNPs-GO-ZnMintPc nanocomposite eliminated E. coli and S. aureus colonies, while the VCL/PEGDA-MNPs-MWCNTs-ZnMintPc nanocomposite was able to kill the three types of microorganisms. Consequently, the latter is considered a broad-spectrum antimicrobial agent in PDT and PTT. MDPI 2022-03-26 /pmc/articles/PMC9028436/ /pubmed/35456539 http://dx.doi.org/10.3390/pharmaceutics14040705 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cuadrado, Coralia Fabiola Díaz-Barrios, Antonio Campaña, Kleber Orlando Romani, Eric Cardona Quiroz, Francisco Nardecchia, Stefania Debut, Alexis Vizuete, Karla Niebieskikwiat, Dario Ávila, Camilo Ernesto Salazar, Mateo Alejandro Garzón-Romero, Cristina Blasco-Zúñiga, Ailín Rivera, Miryan Rosita Romero, María Paulina Broad-Spectrum Antimicrobial ZnMintPc Encapsulated in Magnetic-Nanocomposites with Graphene Oxide/MWCNTs Based on Bimodal Action of Photodynamic and Photothermal Effects |
title | Broad-Spectrum Antimicrobial ZnMintPc Encapsulated in Magnetic-Nanocomposites with Graphene Oxide/MWCNTs Based on Bimodal Action of Photodynamic and Photothermal Effects |
title_full | Broad-Spectrum Antimicrobial ZnMintPc Encapsulated in Magnetic-Nanocomposites with Graphene Oxide/MWCNTs Based on Bimodal Action of Photodynamic and Photothermal Effects |
title_fullStr | Broad-Spectrum Antimicrobial ZnMintPc Encapsulated in Magnetic-Nanocomposites with Graphene Oxide/MWCNTs Based on Bimodal Action of Photodynamic and Photothermal Effects |
title_full_unstemmed | Broad-Spectrum Antimicrobial ZnMintPc Encapsulated in Magnetic-Nanocomposites with Graphene Oxide/MWCNTs Based on Bimodal Action of Photodynamic and Photothermal Effects |
title_short | Broad-Spectrum Antimicrobial ZnMintPc Encapsulated in Magnetic-Nanocomposites with Graphene Oxide/MWCNTs Based on Bimodal Action of Photodynamic and Photothermal Effects |
title_sort | broad-spectrum antimicrobial znmintpc encapsulated in magnetic-nanocomposites with graphene oxide/mwcnts based on bimodal action of photodynamic and photothermal effects |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028436/ https://www.ncbi.nlm.nih.gov/pubmed/35456539 http://dx.doi.org/10.3390/pharmaceutics14040705 |
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