Time-Dependent Odorant Sensitivity Modulation in Insects

SIMPLE SUMMARY: Insects, including blood-feeding female mosquitoes, can transmit deadly diseases, such as malaria, encephalitis, dengue, and yellow fever. Insects use olfaction to locate food sources, mates, and hosts. The nature of odorant plumes poses a challenge for insects in locating odorant sources in the environment. In order to modulate the system for the detection of fresh stimuli or changes in odorant concentrations, the olfaction system desensitizes to different concentrations and durations of stimuli. Without this ability, the chemotaxis behaviors of insects are defective. Thus, understanding how insects adjust their olfactory response dynamics to parse the chemical language of the external environment is not only a basic biology question but also has far-reaching implications for repellents and pest control. ABSTRACT: Insects use olfaction to detect ecologically relevant chemicals in their environment. To maintain useful responses over a variety of stimuli, olfactory receptor neurons are desensitized to prolonged or high concentrations of stimuli. Depending on the timescale, the desensitization is classified as short-term, which typically spans a few seconds; or long-term, which spans from minutes to hours. Compared with the well-studied mechanisms of desensitization in vertebrate olfactory neurons, the mechanisms underlying invertebrate olfactory sensitivity regulation remain poorly understood. Recently, using a large-scale functional screen, a conserved critical receptor phosphorylation site has been identified in the model insect Drosophila melanogaster, providing new insight into the molecular basis of desensitization in insects. Here, we summarize the progress in this area and provide perspectives on future directions to determine the molecular mechanisms that orchestrate the desensitization in insect olfaction.