Cargando…

Detection, Identification and Size Distribution of Silver Nanoparticles (AgNPs) in Milk and Migration Study for Breast Milk Storage Bags

The engineered silver nanoparticles (AgNPs) have been widely used in various food contact materials (FCMs) based on their antibacterial properties. This widespread use of nanosilver has, however, increased the risk of exposure of AgNPs to human due to their migration from FCMs causing a potential ha...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Bin, Chua, Sew Lay, Yu, Dingyi, Chan, Sheot Harn, Li, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028484/
https://www.ncbi.nlm.nih.gov/pubmed/35458739
http://dx.doi.org/10.3390/molecules27082539
_version_ 1784691629488078848
author Li, Bin
Chua, Sew Lay
Yu, Dingyi
Chan, Sheot Harn
Li, Angela
author_facet Li, Bin
Chua, Sew Lay
Yu, Dingyi
Chan, Sheot Harn
Li, Angela
author_sort Li, Bin
collection PubMed
description The engineered silver nanoparticles (AgNPs) have been widely used in various food contact materials (FCMs) based on their antibacterial properties. This widespread use of nanosilver has, however, increased the risk of exposure of AgNPs to human due to their migration from FCMs causing a potential hazard present in foods. Therefore, it is important to establish a reliable and practical method for the detection of AgNPs in food matrices to support risk assessment on AgNPs exposure. Taking the examples of milk and AgNPs-containing breast milk storage bags, this study established an approach for size characterization and quantification of AgNPs in milk and evaluated the relevant silver migration, based on enzymatic digestion and the analysis by asymmetric flow field–flow fractionation (AF4) hyphenated with inductively coupled plasma mass spectrometry (ICP-MS) and single particle inductively coupled plasma mass spectrometry (SP-ICP-MS). No migration of AgNPs was found from breast milk storage bags under various simulated storage conditions as well as extreme scenarios. The suitability and reliability of this method were also validated by the determination of multiple parameters, including accuracy, repeatability, limit of detection (LOD), limit of quantification (LOQ), and recovery, for AF4-ICP-MS and SP-ICP-MS, respectively, with good and overall acceptable evaluation results obtained for all. The established and validated approach was demonstrated to be suitable for the characterization and quantitation of AgNPs in milk as well as the analysis of their migration from breast milk storage bags.
format Online
Article
Text
id pubmed-9028484
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-90284842022-04-23 Detection, Identification and Size Distribution of Silver Nanoparticles (AgNPs) in Milk and Migration Study for Breast Milk Storage Bags Li, Bin Chua, Sew Lay Yu, Dingyi Chan, Sheot Harn Li, Angela Molecules Article The engineered silver nanoparticles (AgNPs) have been widely used in various food contact materials (FCMs) based on their antibacterial properties. This widespread use of nanosilver has, however, increased the risk of exposure of AgNPs to human due to their migration from FCMs causing a potential hazard present in foods. Therefore, it is important to establish a reliable and practical method for the detection of AgNPs in food matrices to support risk assessment on AgNPs exposure. Taking the examples of milk and AgNPs-containing breast milk storage bags, this study established an approach for size characterization and quantification of AgNPs in milk and evaluated the relevant silver migration, based on enzymatic digestion and the analysis by asymmetric flow field–flow fractionation (AF4) hyphenated with inductively coupled plasma mass spectrometry (ICP-MS) and single particle inductively coupled plasma mass spectrometry (SP-ICP-MS). No migration of AgNPs was found from breast milk storage bags under various simulated storage conditions as well as extreme scenarios. The suitability and reliability of this method were also validated by the determination of multiple parameters, including accuracy, repeatability, limit of detection (LOD), limit of quantification (LOQ), and recovery, for AF4-ICP-MS and SP-ICP-MS, respectively, with good and overall acceptable evaluation results obtained for all. The established and validated approach was demonstrated to be suitable for the characterization and quantitation of AgNPs in milk as well as the analysis of their migration from breast milk storage bags. MDPI 2022-04-14 /pmc/articles/PMC9028484/ /pubmed/35458739 http://dx.doi.org/10.3390/molecules27082539 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Bin
Chua, Sew Lay
Yu, Dingyi
Chan, Sheot Harn
Li, Angela
Detection, Identification and Size Distribution of Silver Nanoparticles (AgNPs) in Milk and Migration Study for Breast Milk Storage Bags
title Detection, Identification and Size Distribution of Silver Nanoparticles (AgNPs) in Milk and Migration Study for Breast Milk Storage Bags
title_full Detection, Identification and Size Distribution of Silver Nanoparticles (AgNPs) in Milk and Migration Study for Breast Milk Storage Bags
title_fullStr Detection, Identification and Size Distribution of Silver Nanoparticles (AgNPs) in Milk and Migration Study for Breast Milk Storage Bags
title_full_unstemmed Detection, Identification and Size Distribution of Silver Nanoparticles (AgNPs) in Milk and Migration Study for Breast Milk Storage Bags
title_short Detection, Identification and Size Distribution of Silver Nanoparticles (AgNPs) in Milk and Migration Study for Breast Milk Storage Bags
title_sort detection, identification and size distribution of silver nanoparticles (agnps) in milk and migration study for breast milk storage bags
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028484/
https://www.ncbi.nlm.nih.gov/pubmed/35458739
http://dx.doi.org/10.3390/molecules27082539
work_keys_str_mv AT libin detectionidentificationandsizedistributionofsilvernanoparticlesagnpsinmilkandmigrationstudyforbreastmilkstoragebags
AT chuasewlay detectionidentificationandsizedistributionofsilvernanoparticlesagnpsinmilkandmigrationstudyforbreastmilkstoragebags
AT yudingyi detectionidentificationandsizedistributionofsilvernanoparticlesagnpsinmilkandmigrationstudyforbreastmilkstoragebags
AT chansheotharn detectionidentificationandsizedistributionofsilvernanoparticlesagnpsinmilkandmigrationstudyforbreastmilkstoragebags
AT liangela detectionidentificationandsizedistributionofsilvernanoparticlesagnpsinmilkandmigrationstudyforbreastmilkstoragebags