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Bioengineering Strategies to Create 3D Cardiac Constructs from Human Induced Pluripotent Stem Cells
Human induced pluripotent stem cells (hiPSCs) can be used to generate various cell types in the human body. Hence, hiPSC-derived cardiomyocytes (hiPSC-CMs) represent a significant cell source for disease modeling, drug testing, and regenerative medicine. The immaturity of hiPSC-CMs in two-dimensiona...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028595/ https://www.ncbi.nlm.nih.gov/pubmed/35447728 http://dx.doi.org/10.3390/bioengineering9040168 |
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author | Varzideh, Fahimeh Mone, Pasquale Santulli, Gaetano |
author_facet | Varzideh, Fahimeh Mone, Pasquale Santulli, Gaetano |
author_sort | Varzideh, Fahimeh |
collection | PubMed |
description | Human induced pluripotent stem cells (hiPSCs) can be used to generate various cell types in the human body. Hence, hiPSC-derived cardiomyocytes (hiPSC-CMs) represent a significant cell source for disease modeling, drug testing, and regenerative medicine. The immaturity of hiPSC-CMs in two-dimensional (2D) culture limit their applications. Cardiac tissue engineering provides a new promise for both basic and clinical research. Advanced bioengineered cardiac in vitro models can create contractile structures that serve as exquisite in vitro heart microtissues for drug testing and disease modeling, thereby promoting the identification of better treatments for cardiovascular disorders. In this review, we will introduce recent advances of bioengineering technologies to produce in vitro cardiac tissues derived from hiPSCs. |
format | Online Article Text |
id | pubmed-9028595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90285952022-04-23 Bioengineering Strategies to Create 3D Cardiac Constructs from Human Induced Pluripotent Stem Cells Varzideh, Fahimeh Mone, Pasquale Santulli, Gaetano Bioengineering (Basel) Review Human induced pluripotent stem cells (hiPSCs) can be used to generate various cell types in the human body. Hence, hiPSC-derived cardiomyocytes (hiPSC-CMs) represent a significant cell source for disease modeling, drug testing, and regenerative medicine. The immaturity of hiPSC-CMs in two-dimensional (2D) culture limit their applications. Cardiac tissue engineering provides a new promise for both basic and clinical research. Advanced bioengineered cardiac in vitro models can create contractile structures that serve as exquisite in vitro heart microtissues for drug testing and disease modeling, thereby promoting the identification of better treatments for cardiovascular disorders. In this review, we will introduce recent advances of bioengineering technologies to produce in vitro cardiac tissues derived from hiPSCs. MDPI 2022-04-10 /pmc/articles/PMC9028595/ /pubmed/35447728 http://dx.doi.org/10.3390/bioengineering9040168 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Varzideh, Fahimeh Mone, Pasquale Santulli, Gaetano Bioengineering Strategies to Create 3D Cardiac Constructs from Human Induced Pluripotent Stem Cells |
title | Bioengineering Strategies to Create 3D Cardiac Constructs from Human Induced Pluripotent Stem Cells |
title_full | Bioengineering Strategies to Create 3D Cardiac Constructs from Human Induced Pluripotent Stem Cells |
title_fullStr | Bioengineering Strategies to Create 3D Cardiac Constructs from Human Induced Pluripotent Stem Cells |
title_full_unstemmed | Bioengineering Strategies to Create 3D Cardiac Constructs from Human Induced Pluripotent Stem Cells |
title_short | Bioengineering Strategies to Create 3D Cardiac Constructs from Human Induced Pluripotent Stem Cells |
title_sort | bioengineering strategies to create 3d cardiac constructs from human induced pluripotent stem cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028595/ https://www.ncbi.nlm.nih.gov/pubmed/35447728 http://dx.doi.org/10.3390/bioengineering9040168 |
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