Cargando…

Diabetic Retinopathy Predicts Risk of Alzheimer’s Disease: A Danish Registry-Based Nationwide Cohort Study

BACKGROUND: Retinal neurodegeneration is evident in early diabetic retinopathy (DR) which may be associated with other neurodegenerative diseases like Alzheimer's disease (AD). OBJECTIVE: To investigate diabetes and DR as a risk marker of present and incident AD. METHODS: A register-based cohor...

Descripción completa

Detalles Bibliográficos
Autores principales: Pedersen, Frederik Nørregaard, Stokholm, Lonny, Pouwer, Frans, Hass Rubin, Katrine, Peto, Tunde, Frydkjær-Olsen, Ulrik, Thykjær, Anne Suhr, Andersen, Nis, Andresen, Jens, Bek, Toke, La Cour, Morten, Heegaard, Steffen, Højlund, Kurt, Kawasaki, Ryo, Hajari, Javad Nouri, Ohm Kyvik, Kirsten, Laugesen, Caroline Schmidt, Schielke, Katja Christina, Simó, Rafael, Grauslund, Jakob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028615/
https://www.ncbi.nlm.nih.gov/pubmed/35068460
http://dx.doi.org/10.3233/JAD-215313
_version_ 1784691665092476928
author Pedersen, Frederik Nørregaard
Stokholm, Lonny
Pouwer, Frans
Hass Rubin, Katrine
Peto, Tunde
Frydkjær-Olsen, Ulrik
Thykjær, Anne Suhr
Andersen, Nis
Andresen, Jens
Bek, Toke
La Cour, Morten
Heegaard, Steffen
Højlund, Kurt
Kawasaki, Ryo
Hajari, Javad Nouri
Ohm Kyvik, Kirsten
Laugesen, Caroline Schmidt
Schielke, Katja Christina
Simó, Rafael
Grauslund, Jakob
author_facet Pedersen, Frederik Nørregaard
Stokholm, Lonny
Pouwer, Frans
Hass Rubin, Katrine
Peto, Tunde
Frydkjær-Olsen, Ulrik
Thykjær, Anne Suhr
Andersen, Nis
Andresen, Jens
Bek, Toke
La Cour, Morten
Heegaard, Steffen
Højlund, Kurt
Kawasaki, Ryo
Hajari, Javad Nouri
Ohm Kyvik, Kirsten
Laugesen, Caroline Schmidt
Schielke, Katja Christina
Simó, Rafael
Grauslund, Jakob
author_sort Pedersen, Frederik Nørregaard
collection PubMed
description BACKGROUND: Retinal neurodegeneration is evident in early diabetic retinopathy (DR) which may be associated with other neurodegenerative diseases like Alzheimer's disease (AD). OBJECTIVE: To investigate diabetes and DR as a risk marker of present and incident AD. METHODS: A register-based cohort study was performed. We included 134,327 persons with diabetes above 60 years of age, who had attended DR screening, and 651,936 age- and gender-matched persons without diabetes. RESULTS: At baseline, the prevalence of AD was 0.7% and 1.3% among patients with and without diabetes, respectively. In a multivariable regression model, patients with diabetes were less likely to have AD at baseline (adjusted OR 0.63, 95% CI 0.59–0.68). During follow-up, incident AD was registered for 1473 (0.35%) and 6,899 (0.34%) persons with and without diabetes, respectively. Compared to persons without diabetes, persons with diabetes and no DR had a lower risk to develop AD (adjusted HR 0.87, 95% CI 0.81–0.93), while persons with diabetes and DR had higher risk of AD (adjusted HR 1.24, 95% CI 1.08–1.43). When persons with diabetes and no DR were used as references, a higher risk of incident AD was observed in persons with DR (adjusted HR 1.34, 95% CI 1.18–1.53). CONCLUSION: Individuals with diabetes without DR were less likely to develop AD compared to persons without diabetes. However, individuals with DR had a 34% higher risk of incident AD, which raise the question whether screening for cognitive impairment should be done among individuals with DR.
format Online
Article
Text
id pubmed-9028615
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher IOS Press
record_format MEDLINE/PubMed
spelling pubmed-90286152022-05-06 Diabetic Retinopathy Predicts Risk of Alzheimer’s Disease: A Danish Registry-Based Nationwide Cohort Study Pedersen, Frederik Nørregaard Stokholm, Lonny Pouwer, Frans Hass Rubin, Katrine Peto, Tunde Frydkjær-Olsen, Ulrik Thykjær, Anne Suhr Andersen, Nis Andresen, Jens Bek, Toke La Cour, Morten Heegaard, Steffen Højlund, Kurt Kawasaki, Ryo Hajari, Javad Nouri Ohm Kyvik, Kirsten Laugesen, Caroline Schmidt Schielke, Katja Christina Simó, Rafael Grauslund, Jakob J Alzheimers Dis Research Article BACKGROUND: Retinal neurodegeneration is evident in early diabetic retinopathy (DR) which may be associated with other neurodegenerative diseases like Alzheimer's disease (AD). OBJECTIVE: To investigate diabetes and DR as a risk marker of present and incident AD. METHODS: A register-based cohort study was performed. We included 134,327 persons with diabetes above 60 years of age, who had attended DR screening, and 651,936 age- and gender-matched persons without diabetes. RESULTS: At baseline, the prevalence of AD was 0.7% and 1.3% among patients with and without diabetes, respectively. In a multivariable regression model, patients with diabetes were less likely to have AD at baseline (adjusted OR 0.63, 95% CI 0.59–0.68). During follow-up, incident AD was registered for 1473 (0.35%) and 6,899 (0.34%) persons with and without diabetes, respectively. Compared to persons without diabetes, persons with diabetes and no DR had a lower risk to develop AD (adjusted HR 0.87, 95% CI 0.81–0.93), while persons with diabetes and DR had higher risk of AD (adjusted HR 1.24, 95% CI 1.08–1.43). When persons with diabetes and no DR were used as references, a higher risk of incident AD was observed in persons with DR (adjusted HR 1.34, 95% CI 1.18–1.53). CONCLUSION: Individuals with diabetes without DR were less likely to develop AD compared to persons without diabetes. However, individuals with DR had a 34% higher risk of incident AD, which raise the question whether screening for cognitive impairment should be done among individuals with DR. IOS Press 2022-03-08 /pmc/articles/PMC9028615/ /pubmed/35068460 http://dx.doi.org/10.3233/JAD-215313 Text en © 2022 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Pedersen, Frederik Nørregaard
Stokholm, Lonny
Pouwer, Frans
Hass Rubin, Katrine
Peto, Tunde
Frydkjær-Olsen, Ulrik
Thykjær, Anne Suhr
Andersen, Nis
Andresen, Jens
Bek, Toke
La Cour, Morten
Heegaard, Steffen
Højlund, Kurt
Kawasaki, Ryo
Hajari, Javad Nouri
Ohm Kyvik, Kirsten
Laugesen, Caroline Schmidt
Schielke, Katja Christina
Simó, Rafael
Grauslund, Jakob
Diabetic Retinopathy Predicts Risk of Alzheimer’s Disease: A Danish Registry-Based Nationwide Cohort Study
title Diabetic Retinopathy Predicts Risk of Alzheimer’s Disease: A Danish Registry-Based Nationwide Cohort Study
title_full Diabetic Retinopathy Predicts Risk of Alzheimer’s Disease: A Danish Registry-Based Nationwide Cohort Study
title_fullStr Diabetic Retinopathy Predicts Risk of Alzheimer’s Disease: A Danish Registry-Based Nationwide Cohort Study
title_full_unstemmed Diabetic Retinopathy Predicts Risk of Alzheimer’s Disease: A Danish Registry-Based Nationwide Cohort Study
title_short Diabetic Retinopathy Predicts Risk of Alzheimer’s Disease: A Danish Registry-Based Nationwide Cohort Study
title_sort diabetic retinopathy predicts risk of alzheimer’s disease: a danish registry-based nationwide cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028615/
https://www.ncbi.nlm.nih.gov/pubmed/35068460
http://dx.doi.org/10.3233/JAD-215313
work_keys_str_mv AT pedersenfrederiknørregaard diabeticretinopathypredictsriskofalzheimersdiseaseadanishregistrybasednationwidecohortstudy
AT stokholmlonny diabeticretinopathypredictsriskofalzheimersdiseaseadanishregistrybasednationwidecohortstudy
AT pouwerfrans diabeticretinopathypredictsriskofalzheimersdiseaseadanishregistrybasednationwidecohortstudy
AT hassrubinkatrine diabeticretinopathypredictsriskofalzheimersdiseaseadanishregistrybasednationwidecohortstudy
AT petotunde diabeticretinopathypredictsriskofalzheimersdiseaseadanishregistrybasednationwidecohortstudy
AT frydkjærolsenulrik diabeticretinopathypredictsriskofalzheimersdiseaseadanishregistrybasednationwidecohortstudy
AT thykjærannesuhr diabeticretinopathypredictsriskofalzheimersdiseaseadanishregistrybasednationwidecohortstudy
AT andersennis diabeticretinopathypredictsriskofalzheimersdiseaseadanishregistrybasednationwidecohortstudy
AT andresenjens diabeticretinopathypredictsriskofalzheimersdiseaseadanishregistrybasednationwidecohortstudy
AT bektoke diabeticretinopathypredictsriskofalzheimersdiseaseadanishregistrybasednationwidecohortstudy
AT lacourmorten diabeticretinopathypredictsriskofalzheimersdiseaseadanishregistrybasednationwidecohortstudy
AT heegaardsteffen diabeticretinopathypredictsriskofalzheimersdiseaseadanishregistrybasednationwidecohortstudy
AT højlundkurt diabeticretinopathypredictsriskofalzheimersdiseaseadanishregistrybasednationwidecohortstudy
AT kawasakiryo diabeticretinopathypredictsriskofalzheimersdiseaseadanishregistrybasednationwidecohortstudy
AT hajarijavadnouri diabeticretinopathypredictsriskofalzheimersdiseaseadanishregistrybasednationwidecohortstudy
AT ohmkyvikkirsten diabeticretinopathypredictsriskofalzheimersdiseaseadanishregistrybasednationwidecohortstudy
AT laugesencarolineschmidt diabeticretinopathypredictsriskofalzheimersdiseaseadanishregistrybasednationwidecohortstudy
AT schielkekatjachristina diabeticretinopathypredictsriskofalzheimersdiseaseadanishregistrybasednationwidecohortstudy
AT simorafael diabeticretinopathypredictsriskofalzheimersdiseaseadanishregistrybasednationwidecohortstudy
AT grauslundjakob diabeticretinopathypredictsriskofalzheimersdiseaseadanishregistrybasednationwidecohortstudy