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Evaluating dose distributions of normal organs for patients undergoing VMAT therapy of nasopharyngeal carcinoma using Rando phantom and TLD-100H

BACKGROUND: The routine radiation therapy treatment planning does not include secondary radiation and peripheral doses resulting from radiotherapy exposure in patients with nasopharyngeal carcinoma (NPC) undergoing Volumetric Modulated Arc Therapy (VMAT) using an linear accelerator (linac) of Axesse...

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Autores principales: Chen, Yun-Chih, Lin, Hung-Chih, Lai, Wei-Hou, Hung, Hung-Chang, Tseng, Hsien-Chun, Chen, Chien-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028652/
https://www.ncbi.nlm.nih.gov/pubmed/35124609
http://dx.doi.org/10.3233/THC-THC228031
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author Chen, Yun-Chih
Lin, Hung-Chih
Lai, Wei-Hou
Hung, Hung-Chang
Tseng, Hsien-Chun
Chen, Chien-Yi
author_facet Chen, Yun-Chih
Lin, Hung-Chih
Lai, Wei-Hou
Hung, Hung-Chang
Tseng, Hsien-Chun
Chen, Chien-Yi
author_sort Chen, Yun-Chih
collection PubMed
description BACKGROUND: The routine radiation therapy treatment planning does not include secondary radiation and peripheral doses resulting from radiotherapy exposure in patients with nasopharyngeal carcinoma (NPC) undergoing Volumetric Modulated Arc Therapy (VMAT) using an linear accelerator (linac) of Axesse (Elekta 2538). OBJECTIVE: VMAT has a better dose conformity of the tumor and is also operated by adjusting the shapes of mulileaf collimator. However, such treatment is potentially important to improve the accuracy of estimated health risks. METHODS: This study aimed to evaluate the equivalent dose of organ or tissue ([Formula: see text]) and effective dose ([Formula: see text]) for normal organs using the Alderson Rando phantom as an equivalent of the human body. Thermoluminescent dosimeters (TLD-100H) were calibrated by 6 MV X-ray originated by the linac. A total of 252 TLDs were used. These TLDs were inserted into phantom organ or tissue which closely approximated to these places. RESULTS: The thyroid dose ([Formula: see text]) had the highest dose, 1840 [Formula: see text] 202 mSv/treatment. The [Formula: see text] of the Rando was 7.11 [Formula: see text] 0.61 mSv/treatment, as estimated using ICRP 103. The skin doses ([Formula: see text]) varied significantly outside the treatment field and decreased as the distance from the treatment field increased. CONCLUSIONS: This study can be referred to practical guidance regarding radiation protections of the public.
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spelling pubmed-90286522022-05-06 Evaluating dose distributions of normal organs for patients undergoing VMAT therapy of nasopharyngeal carcinoma using Rando phantom and TLD-100H Chen, Yun-Chih Lin, Hung-Chih Lai, Wei-Hou Hung, Hung-Chang Tseng, Hsien-Chun Chen, Chien-Yi Technol Health Care Research Article BACKGROUND: The routine radiation therapy treatment planning does not include secondary radiation and peripheral doses resulting from radiotherapy exposure in patients with nasopharyngeal carcinoma (NPC) undergoing Volumetric Modulated Arc Therapy (VMAT) using an linear accelerator (linac) of Axesse (Elekta 2538). OBJECTIVE: VMAT has a better dose conformity of the tumor and is also operated by adjusting the shapes of mulileaf collimator. However, such treatment is potentially important to improve the accuracy of estimated health risks. METHODS: This study aimed to evaluate the equivalent dose of organ or tissue ([Formula: see text]) and effective dose ([Formula: see text]) for normal organs using the Alderson Rando phantom as an equivalent of the human body. Thermoluminescent dosimeters (TLD-100H) were calibrated by 6 MV X-ray originated by the linac. A total of 252 TLDs were used. These TLDs were inserted into phantom organ or tissue which closely approximated to these places. RESULTS: The thyroid dose ([Formula: see text]) had the highest dose, 1840 [Formula: see text] 202 mSv/treatment. The [Formula: see text] of the Rando was 7.11 [Formula: see text] 0.61 mSv/treatment, as estimated using ICRP 103. The skin doses ([Formula: see text]) varied significantly outside the treatment field and decreased as the distance from the treatment field increased. CONCLUSIONS: This study can be referred to practical guidance regarding radiation protections of the public. IOS Press 2022-03-08 /pmc/articles/PMC9028652/ /pubmed/35124609 http://dx.doi.org/10.3233/THC-THC228031 Text en © 2022 – The authors. Published by IOS Press. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Yun-Chih
Lin, Hung-Chih
Lai, Wei-Hou
Hung, Hung-Chang
Tseng, Hsien-Chun
Chen, Chien-Yi
Evaluating dose distributions of normal organs for patients undergoing VMAT therapy of nasopharyngeal carcinoma using Rando phantom and TLD-100H
title Evaluating dose distributions of normal organs for patients undergoing VMAT therapy of nasopharyngeal carcinoma using Rando phantom and TLD-100H
title_full Evaluating dose distributions of normal organs for patients undergoing VMAT therapy of nasopharyngeal carcinoma using Rando phantom and TLD-100H
title_fullStr Evaluating dose distributions of normal organs for patients undergoing VMAT therapy of nasopharyngeal carcinoma using Rando phantom and TLD-100H
title_full_unstemmed Evaluating dose distributions of normal organs for patients undergoing VMAT therapy of nasopharyngeal carcinoma using Rando phantom and TLD-100H
title_short Evaluating dose distributions of normal organs for patients undergoing VMAT therapy of nasopharyngeal carcinoma using Rando phantom and TLD-100H
title_sort evaluating dose distributions of normal organs for patients undergoing vmat therapy of nasopharyngeal carcinoma using rando phantom and tld-100h
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028652/
https://www.ncbi.nlm.nih.gov/pubmed/35124609
http://dx.doi.org/10.3233/THC-THC228031
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