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The Compound ATH434 Prevents Alpha-Synuclein Toxicity in a Murine Model of Multiple System Atrophy

BACKGROUND: An elevation in iron levels, together with an accumulation of α-synuclein within the oligodendrocytes, are features of the rare atypical parkinsonian disorder, Multiple System Atrophy (MSA). We have previously tested the novel compound ATH434 (formally called PBT434) in preclinical model...

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Detalles Bibliográficos
Autores principales:	Finkelstein, David I., Shukla, Jay J., Cherny, Robert A., Billings, Jessica L., Saleh, Eiman, Stefanova, Nadia, Barnham, Kevin J., Adlard, Paul A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2022
Materias:	Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028676/ https://www.ncbi.nlm.nih.gov/pubmed/34744051 http://dx.doi.org/10.3233/JPD-212877

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