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The Chemically Highly Diversified Metabolites from the Red Sea Marine Sponge Spongia sp.

A polyoxygenated and halogenated labdane, spongianol (1); a polyoxygenated steroid, 3β,5α,9α-trihydroxy-24S-ethylcholest-7-en-6-one (2); a rare seven-membered lactone B ring, (22E,24S)-ergosta-7,22-dien-3β,5α-diol-6,5-olide (3); and an α,β-unsaturated fatty acid, (Z)-3-methyl-9-oxodec-2-enoic acid (...

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Autores principales: Tai, Chi-Jen, Ahmed, Atallah F., Chao, Chih-Hua, Yen, Chia-Hung, Hwang, Tsong-Long, Chang, Fang-Rong, Huang, Yusheng M., Sheu, Jyh-Horng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028682/
https://www.ncbi.nlm.nih.gov/pubmed/35447914
http://dx.doi.org/10.3390/md20040241
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author Tai, Chi-Jen
Ahmed, Atallah F.
Chao, Chih-Hua
Yen, Chia-Hung
Hwang, Tsong-Long
Chang, Fang-Rong
Huang, Yusheng M.
Sheu, Jyh-Horng
author_facet Tai, Chi-Jen
Ahmed, Atallah F.
Chao, Chih-Hua
Yen, Chia-Hung
Hwang, Tsong-Long
Chang, Fang-Rong
Huang, Yusheng M.
Sheu, Jyh-Horng
author_sort Tai, Chi-Jen
collection PubMed
description A polyoxygenated and halogenated labdane, spongianol (1); a polyoxygenated steroid, 3β,5α,9α-trihydroxy-24S-ethylcholest-7-en-6-one (2); a rare seven-membered lactone B ring, (22E,24S)-ergosta-7,22-dien-3β,5α-diol-6,5-olide (3); and an α,β-unsaturated fatty acid, (Z)-3-methyl-9-oxodec-2-enoic acid (4) as well as five known compounds, 10-hydroxykahukuene B (5), pacifenol (6), dysidamide (7), 7,7,7-trichloro-3-hydroxy-2,2,6-trimethyl-4-(4,4,4-trichloro-3-methyl-1-oxobu-tylamino)-heptanoic acid methyl ester (8), and the primary metabolite 2’-deoxynucleoside thymidine (9), have been isolated from the Red Sea sponge Spongia sp. The stereoisomer of 3 was discovered in Ganoderma resinaceum, and metabolites 5 and 6, isolated previously from red algae, were characterized unprecedentedly in the sponge. Compounds 7 and 8 have not been found before in the genus Spongia. Compounds 1–9 were also assayed for cytotoxicity as well as antibacterial and anti-inflammatory activities.
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spelling pubmed-90286822022-04-23 The Chemically Highly Diversified Metabolites from the Red Sea Marine Sponge Spongia sp. Tai, Chi-Jen Ahmed, Atallah F. Chao, Chih-Hua Yen, Chia-Hung Hwang, Tsong-Long Chang, Fang-Rong Huang, Yusheng M. Sheu, Jyh-Horng Mar Drugs Article A polyoxygenated and halogenated labdane, spongianol (1); a polyoxygenated steroid, 3β,5α,9α-trihydroxy-24S-ethylcholest-7-en-6-one (2); a rare seven-membered lactone B ring, (22E,24S)-ergosta-7,22-dien-3β,5α-diol-6,5-olide (3); and an α,β-unsaturated fatty acid, (Z)-3-methyl-9-oxodec-2-enoic acid (4) as well as five known compounds, 10-hydroxykahukuene B (5), pacifenol (6), dysidamide (7), 7,7,7-trichloro-3-hydroxy-2,2,6-trimethyl-4-(4,4,4-trichloro-3-methyl-1-oxobu-tylamino)-heptanoic acid methyl ester (8), and the primary metabolite 2’-deoxynucleoside thymidine (9), have been isolated from the Red Sea sponge Spongia sp. The stereoisomer of 3 was discovered in Ganoderma resinaceum, and metabolites 5 and 6, isolated previously from red algae, were characterized unprecedentedly in the sponge. Compounds 7 and 8 have not been found before in the genus Spongia. Compounds 1–9 were also assayed for cytotoxicity as well as antibacterial and anti-inflammatory activities. MDPI 2022-03-30 /pmc/articles/PMC9028682/ /pubmed/35447914 http://dx.doi.org/10.3390/md20040241 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tai, Chi-Jen
Ahmed, Atallah F.
Chao, Chih-Hua
Yen, Chia-Hung
Hwang, Tsong-Long
Chang, Fang-Rong
Huang, Yusheng M.
Sheu, Jyh-Horng
The Chemically Highly Diversified Metabolites from the Red Sea Marine Sponge Spongia sp.
title The Chemically Highly Diversified Metabolites from the Red Sea Marine Sponge Spongia sp.
title_full The Chemically Highly Diversified Metabolites from the Red Sea Marine Sponge Spongia sp.
title_fullStr The Chemically Highly Diversified Metabolites from the Red Sea Marine Sponge Spongia sp.
title_full_unstemmed The Chemically Highly Diversified Metabolites from the Red Sea Marine Sponge Spongia sp.
title_short The Chemically Highly Diversified Metabolites from the Red Sea Marine Sponge Spongia sp.
title_sort chemically highly diversified metabolites from the red sea marine sponge spongia sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028682/
https://www.ncbi.nlm.nih.gov/pubmed/35447914
http://dx.doi.org/10.3390/md20040241
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