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Temporal Phenotypic Changes in Huntington’s Disease Models for Preclinical Studies

BACKGROUND: Mouse models bearing genetic disease mutations are instrumental in the development of therapies for genetic disorders. Huntington’s disease (HD) is a late-onset lethal dominant genetic disorder due to a CAG repeat within exon 1 of the Huntingtin (Htt) gene. Several mice were developed to...

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Detalles Bibliográficos
Autores principales:	St-Cyr, Sophie, Smith, Alicia R., Davidson, Beverly L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2022
Materias:	Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028736/ https://www.ncbi.nlm.nih.gov/pubmed/35213386 http://dx.doi.org/10.3233/JHD-210515

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