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Side Effects of Mixing Vaccines against COVID-19 Infection among Saudi Population

Background: Mixing two different vaccines has been utilized to minimize the impact of any supply chain interruptions and to combat the COVID-19 pandemic in Saudi Arabia. We conducted this study to evaluate the side effects, if any, associated with the mixed vaccination approach. Methods: An online s...

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Autores principales: Alshahrani, Mohammed Merae, Alqahtani, Abdulaziz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028800/
https://www.ncbi.nlm.nih.gov/pubmed/35455268
http://dx.doi.org/10.3390/vaccines10040519
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author Alshahrani, Mohammed Merae
Alqahtani, Abdulaziz
author_facet Alshahrani, Mohammed Merae
Alqahtani, Abdulaziz
author_sort Alshahrani, Mohammed Merae
collection PubMed
description Background: Mixing two different vaccines has been utilized to minimize the impact of any supply chain interruptions and to combat the COVID-19 pandemic in Saudi Arabia. We conducted this study to evaluate the side effects, if any, associated with the mixed vaccination approach. Methods: An online survey study was administered among COVID-19 vaccine recipients in Saudi Arabia. Symptoms post vaccination were assessed in 311 vaccinated participants with two matched doses of either Oxford–AstraZeneca or Pfizer–BioNTech vaccines, or two mixed doses, respectively. Results: After the second dose, around 31% of the matched vaccine group reported no symptoms, while only 6% of the mixed vaccine group reported no symptoms. Most of the side effects after the second dose associated with matched vaccines were injection site pain (46%), while the mixed vaccines group reported significantly more symptoms compared with the matched vaccine group, which included fever (41%), fatigue (66%), muscle pain (44%), chills (17%) and injection site pain (60%). Conclusion: The data suggest the overall safety of the mixed vaccination protocol; however, it might be associated with side effects such as fever, fatigue, muscle pain, chills, and injection site pain. Further studies with a larger cohort size could shed more light on this aspect, which would be imperative for deciding to utilize a mixed vaccination approach.
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spelling pubmed-90288002022-04-23 Side Effects of Mixing Vaccines against COVID-19 Infection among Saudi Population Alshahrani, Mohammed Merae Alqahtani, Abdulaziz Vaccines (Basel) Article Background: Mixing two different vaccines has been utilized to minimize the impact of any supply chain interruptions and to combat the COVID-19 pandemic in Saudi Arabia. We conducted this study to evaluate the side effects, if any, associated with the mixed vaccination approach. Methods: An online survey study was administered among COVID-19 vaccine recipients in Saudi Arabia. Symptoms post vaccination were assessed in 311 vaccinated participants with two matched doses of either Oxford–AstraZeneca or Pfizer–BioNTech vaccines, or two mixed doses, respectively. Results: After the second dose, around 31% of the matched vaccine group reported no symptoms, while only 6% of the mixed vaccine group reported no symptoms. Most of the side effects after the second dose associated with matched vaccines were injection site pain (46%), while the mixed vaccines group reported significantly more symptoms compared with the matched vaccine group, which included fever (41%), fatigue (66%), muscle pain (44%), chills (17%) and injection site pain (60%). Conclusion: The data suggest the overall safety of the mixed vaccination protocol; however, it might be associated with side effects such as fever, fatigue, muscle pain, chills, and injection site pain. Further studies with a larger cohort size could shed more light on this aspect, which would be imperative for deciding to utilize a mixed vaccination approach. MDPI 2022-03-27 /pmc/articles/PMC9028800/ /pubmed/35455268 http://dx.doi.org/10.3390/vaccines10040519 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alshahrani, Mohammed Merae
Alqahtani, Abdulaziz
Side Effects of Mixing Vaccines against COVID-19 Infection among Saudi Population
title Side Effects of Mixing Vaccines against COVID-19 Infection among Saudi Population
title_full Side Effects of Mixing Vaccines against COVID-19 Infection among Saudi Population
title_fullStr Side Effects of Mixing Vaccines against COVID-19 Infection among Saudi Population
title_full_unstemmed Side Effects of Mixing Vaccines against COVID-19 Infection among Saudi Population
title_short Side Effects of Mixing Vaccines against COVID-19 Infection among Saudi Population
title_sort side effects of mixing vaccines against covid-19 infection among saudi population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028800/
https://www.ncbi.nlm.nih.gov/pubmed/35455268
http://dx.doi.org/10.3390/vaccines10040519
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