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Chromosome Territories in Hematological Malignancies

Chromosomes are organized in distinct nuclear areas designated as chromosome territories (CT). The structural formation of CT is a consequence of chromatin packaging and organization that ultimately affects cell function. Chromosome positioning can identify structural signatures of genomic organizat...

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Autores principales: de Lima, Matheus Fabiao, Lisboa, Mateus de Oliveira, Terceiro, Lucas E. L., Rangel-Pozzo, Aline, Mai, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028803/
https://www.ncbi.nlm.nih.gov/pubmed/35456046
http://dx.doi.org/10.3390/cells11081368
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author de Lima, Matheus Fabiao
Lisboa, Mateus de Oliveira
Terceiro, Lucas E. L.
Rangel-Pozzo, Aline
Mai, Sabine
author_facet de Lima, Matheus Fabiao
Lisboa, Mateus de Oliveira
Terceiro, Lucas E. L.
Rangel-Pozzo, Aline
Mai, Sabine
author_sort de Lima, Matheus Fabiao
collection PubMed
description Chromosomes are organized in distinct nuclear areas designated as chromosome territories (CT). The structural formation of CT is a consequence of chromatin packaging and organization that ultimately affects cell function. Chromosome positioning can identify structural signatures of genomic organization, especially for diseases where changes in gene expression contribute to a given phenotype. The study of CT in hematological diseases revealed chromosome position as an important factor for specific chromosome translocations. In this review, we highlight the history of CT theory, current knowledge on possible clinical applications of CT analysis, and the impact of CT in the development of hematological neoplasia such as multiple myeloma, leukemia, and lymphomas. Accumulating data on nuclear architecture in cancer allow one to propose the three-dimensional nuclear genomic landscape as a novel cancer biomarker for the future.
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spelling pubmed-90288032022-04-23 Chromosome Territories in Hematological Malignancies de Lima, Matheus Fabiao Lisboa, Mateus de Oliveira Terceiro, Lucas E. L. Rangel-Pozzo, Aline Mai, Sabine Cells Review Chromosomes are organized in distinct nuclear areas designated as chromosome territories (CT). The structural formation of CT is a consequence of chromatin packaging and organization that ultimately affects cell function. Chromosome positioning can identify structural signatures of genomic organization, especially for diseases where changes in gene expression contribute to a given phenotype. The study of CT in hematological diseases revealed chromosome position as an important factor for specific chromosome translocations. In this review, we highlight the history of CT theory, current knowledge on possible clinical applications of CT analysis, and the impact of CT in the development of hematological neoplasia such as multiple myeloma, leukemia, and lymphomas. Accumulating data on nuclear architecture in cancer allow one to propose the three-dimensional nuclear genomic landscape as a novel cancer biomarker for the future. MDPI 2022-04-17 /pmc/articles/PMC9028803/ /pubmed/35456046 http://dx.doi.org/10.3390/cells11081368 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
de Lima, Matheus Fabiao
Lisboa, Mateus de Oliveira
Terceiro, Lucas E. L.
Rangel-Pozzo, Aline
Mai, Sabine
Chromosome Territories in Hematological Malignancies
title Chromosome Territories in Hematological Malignancies
title_full Chromosome Territories in Hematological Malignancies
title_fullStr Chromosome Territories in Hematological Malignancies
title_full_unstemmed Chromosome Territories in Hematological Malignancies
title_short Chromosome Territories in Hematological Malignancies
title_sort chromosome territories in hematological malignancies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028803/
https://www.ncbi.nlm.nih.gov/pubmed/35456046
http://dx.doi.org/10.3390/cells11081368
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