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Vitamin D Related Gene Polymorphisms and Cholesterol Levels in a Mediterranean Population
In addition to its role in bone health, vitamin D (VitD) has been implicated in several pathological conditions. Specifically, VitD deficiency has been linked to an increased risk of dyslipidemia. Atherogenic dyslipidemia is characterized by increased low-density lipoprotein-cholesterol (LDL-C) and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028837/ https://www.ncbi.nlm.nih.gov/pubmed/35448078 http://dx.doi.org/10.3390/jcdd9040102 |
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author | Fakhoury, Hana M. A. El Shamieh, Said Rifai, Amru Tamim, Hani Fakhoury, Rajaa |
author_facet | Fakhoury, Hana M. A. El Shamieh, Said Rifai, Amru Tamim, Hani Fakhoury, Rajaa |
author_sort | Fakhoury, Hana M. A. |
collection | PubMed |
description | In addition to its role in bone health, vitamin D (VitD) has been implicated in several pathological conditions. Specifically, VitD deficiency has been linked to an increased risk of dyslipidemia. Atherogenic dyslipidemia is characterized by increased low-density lipoprotein-cholesterol (LDL-C) and decreased high-density lipoprotein-cholesterol (HDL-C). In this study, we examined the association of six single nucleotide polymorphisms (SNPs) in VitD-related genes with VitD and lipid levels, in a cohort of 460 Lebanese participants free from chronic diseases. Our results showed no association of the examined SNPs with VitD concentrations. However, the presence of the minor allele in rs10741657G>A of CYP2R1 was associated with increased levels in LDL-C (β = 4.95, p = 0.04)] and decreased levels in HDL-C (β = −1.76, p = 0.007)]. Interestingly, rs10741657G>A interacted with gender to increase LDL-C levels in females (β = 6.73 and p = 0.03) and decrease HDL-C levels in males HDL-C (β = −1.09, p = 0.009). In conclusion, our results suggest that rs10741657 G>A in CYP2R1 is associated with circulating LDL-C and HDL-C levels in a Lebanese cohort. Although this association was gender-specific, where rs10741657G>A was associated with increased LDL in females and decreased HDL in males, the presence of the minor allele A was associated with increased cardiovascular risk in both genders. These findings need to be validated in a larger population. Further investigations are warranted to elucidate the molecular mechanism of VitD polymorphism and dyslipidemia. |
format | Online Article Text |
id | pubmed-9028837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90288372022-04-23 Vitamin D Related Gene Polymorphisms and Cholesterol Levels in a Mediterranean Population Fakhoury, Hana M. A. El Shamieh, Said Rifai, Amru Tamim, Hani Fakhoury, Rajaa J Cardiovasc Dev Dis Article In addition to its role in bone health, vitamin D (VitD) has been implicated in several pathological conditions. Specifically, VitD deficiency has been linked to an increased risk of dyslipidemia. Atherogenic dyslipidemia is characterized by increased low-density lipoprotein-cholesterol (LDL-C) and decreased high-density lipoprotein-cholesterol (HDL-C). In this study, we examined the association of six single nucleotide polymorphisms (SNPs) in VitD-related genes with VitD and lipid levels, in a cohort of 460 Lebanese participants free from chronic diseases. Our results showed no association of the examined SNPs with VitD concentrations. However, the presence of the minor allele in rs10741657G>A of CYP2R1 was associated with increased levels in LDL-C (β = 4.95, p = 0.04)] and decreased levels in HDL-C (β = −1.76, p = 0.007)]. Interestingly, rs10741657G>A interacted with gender to increase LDL-C levels in females (β = 6.73 and p = 0.03) and decrease HDL-C levels in males HDL-C (β = −1.09, p = 0.009). In conclusion, our results suggest that rs10741657 G>A in CYP2R1 is associated with circulating LDL-C and HDL-C levels in a Lebanese cohort. Although this association was gender-specific, where rs10741657G>A was associated with increased LDL in females and decreased HDL in males, the presence of the minor allele A was associated with increased cardiovascular risk in both genders. These findings need to be validated in a larger population. Further investigations are warranted to elucidate the molecular mechanism of VitD polymorphism and dyslipidemia. MDPI 2022-03-27 /pmc/articles/PMC9028837/ /pubmed/35448078 http://dx.doi.org/10.3390/jcdd9040102 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fakhoury, Hana M. A. El Shamieh, Said Rifai, Amru Tamim, Hani Fakhoury, Rajaa Vitamin D Related Gene Polymorphisms and Cholesterol Levels in a Mediterranean Population |
title | Vitamin D Related Gene Polymorphisms and Cholesterol Levels in a Mediterranean Population |
title_full | Vitamin D Related Gene Polymorphisms and Cholesterol Levels in a Mediterranean Population |
title_fullStr | Vitamin D Related Gene Polymorphisms and Cholesterol Levels in a Mediterranean Population |
title_full_unstemmed | Vitamin D Related Gene Polymorphisms and Cholesterol Levels in a Mediterranean Population |
title_short | Vitamin D Related Gene Polymorphisms and Cholesterol Levels in a Mediterranean Population |
title_sort | vitamin d related gene polymorphisms and cholesterol levels in a mediterranean population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028837/ https://www.ncbi.nlm.nih.gov/pubmed/35448078 http://dx.doi.org/10.3390/jcdd9040102 |
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