Preclinical Efficacy and Toxicity Analysis of the Pan-Histone Deacetylase Inhibitor Gossypol for the Therapy of Colorectal Cancer or Hepatocellular Carcinoma

Gossypol, a sesquiterpenoid found in cotton seeds, exerts anticancer effects on several tumor entities due to inhibition of DNA synthesis and other mechanisms. In clinical oncology, histone deacetylase inhibitors (HDACi) are applied as anticancer compounds. In this study, we examined whether gossypo...

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Detalles Bibliográficos
Autores principales: Mayer, Mascha, Berger, Alexander, Leischner, Christian, Renner, Olga, Burkard, Markus, Böcker, Alexander, Noor, Seema, Weiland, Timo, Weiss, Thomas S., Busch, Christian, Lauer, Ulrich M., Bischoff, Stephan C., Venturelli, Sascha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028974/
https://www.ncbi.nlm.nih.gov/pubmed/35455435
http://dx.doi.org/10.3390/ph15040438

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