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Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gastrointestinal Tract: A Case Series

Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) refer to heterogenous rare neoplasms constituted of at least a neuroendocrine population—either well-differentiated, or more frequently poorly differentiated—and a non-neuroendocrine population, both accounting for at least 30% of the whole...

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Autores principales: Guerrera, Luigi Pio, Suarato, Gabriella, Napolitano, Rossella, Perrone, Alessandra, Caputo, Vincenza, Ventriglia, Anna, Martini, Giulia, Della Corte, Carminia Maria, Orditura, Michele, Martinelli, Erika, Ciardiello, Fortunato, Montella, Marco, Franco, Renato, Troiani, Teresa, Napolitano, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028985/
https://www.ncbi.nlm.nih.gov/pubmed/35455885
http://dx.doi.org/10.3390/healthcare10040708
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author Guerrera, Luigi Pio
Suarato, Gabriella
Napolitano, Rossella
Perrone, Alessandra
Caputo, Vincenza
Ventriglia, Anna
Martini, Giulia
Della Corte, Carminia Maria
Orditura, Michele
Martinelli, Erika
Ciardiello, Fortunato
Montella, Marco
Franco, Renato
Troiani, Teresa
Napolitano, Stefania
author_facet Guerrera, Luigi Pio
Suarato, Gabriella
Napolitano, Rossella
Perrone, Alessandra
Caputo, Vincenza
Ventriglia, Anna
Martini, Giulia
Della Corte, Carminia Maria
Orditura, Michele
Martinelli, Erika
Ciardiello, Fortunato
Montella, Marco
Franco, Renato
Troiani, Teresa
Napolitano, Stefania
author_sort Guerrera, Luigi Pio
collection PubMed
description Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) refer to heterogenous rare neoplasms constituted of at least a neuroendocrine population—either well-differentiated, or more frequently poorly differentiated—and a non-neuroendocrine population, both accounting for at least 30% of the whole tumor mass. Several studies recently focused on the key genetic and epigenetic changes underlying MiNENs to better understand how they develop, and explore biological similarities among the two components and their pure counterparts. However, their molecular landscape still remains poorly understood. NGS may represent a useful tool to study this orphan disease by detecting the main genetic alterations and possible therapeutic targets. NGS analysis on tissue and/or blood samples through the Foundation One (F1) platform was performed on consecutive samples collected from four patients diagnosed with MiNENs of the gastroenteric tract. Several genetic alterations were shared among samples from the same patients, thus suggesting a common origin between them, although morphology sometimes changed at histopathological evaluation. Common molecular alterations among samples from different patients that had not been previously described to our knowledge were also detected. Finally, it is of the utmost importance to clarify if the maintenance of the 30% cut-off is still essential in defining MiNENs and really manages to include all of the mixed neoplasms.
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spelling pubmed-90289852022-04-23 Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gastrointestinal Tract: A Case Series Guerrera, Luigi Pio Suarato, Gabriella Napolitano, Rossella Perrone, Alessandra Caputo, Vincenza Ventriglia, Anna Martini, Giulia Della Corte, Carminia Maria Orditura, Michele Martinelli, Erika Ciardiello, Fortunato Montella, Marco Franco, Renato Troiani, Teresa Napolitano, Stefania Healthcare (Basel) Case Report Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) refer to heterogenous rare neoplasms constituted of at least a neuroendocrine population—either well-differentiated, or more frequently poorly differentiated—and a non-neuroendocrine population, both accounting for at least 30% of the whole tumor mass. Several studies recently focused on the key genetic and epigenetic changes underlying MiNENs to better understand how they develop, and explore biological similarities among the two components and their pure counterparts. However, their molecular landscape still remains poorly understood. NGS may represent a useful tool to study this orphan disease by detecting the main genetic alterations and possible therapeutic targets. NGS analysis on tissue and/or blood samples through the Foundation One (F1) platform was performed on consecutive samples collected from four patients diagnosed with MiNENs of the gastroenteric tract. Several genetic alterations were shared among samples from the same patients, thus suggesting a common origin between them, although morphology sometimes changed at histopathological evaluation. Common molecular alterations among samples from different patients that had not been previously described to our knowledge were also detected. Finally, it is of the utmost importance to clarify if the maintenance of the 30% cut-off is still essential in defining MiNENs and really manages to include all of the mixed neoplasms. MDPI 2022-04-11 /pmc/articles/PMC9028985/ /pubmed/35455885 http://dx.doi.org/10.3390/healthcare10040708 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Guerrera, Luigi Pio
Suarato, Gabriella
Napolitano, Rossella
Perrone, Alessandra
Caputo, Vincenza
Ventriglia, Anna
Martini, Giulia
Della Corte, Carminia Maria
Orditura, Michele
Martinelli, Erika
Ciardiello, Fortunato
Montella, Marco
Franco, Renato
Troiani, Teresa
Napolitano, Stefania
Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gastrointestinal Tract: A Case Series
title Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gastrointestinal Tract: A Case Series
title_full Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gastrointestinal Tract: A Case Series
title_fullStr Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gastrointestinal Tract: A Case Series
title_full_unstemmed Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gastrointestinal Tract: A Case Series
title_short Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gastrointestinal Tract: A Case Series
title_sort mixed neuroendocrine non-neuroendocrine neoplasms of the gastrointestinal tract: a case series
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028985/
https://www.ncbi.nlm.nih.gov/pubmed/35455885
http://dx.doi.org/10.3390/healthcare10040708
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