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Hypertriglyceridaemia-Induced Acute Pancreatitis: A Different Disease Phenotype

Acute pancreatitis (AP) is the most common gastrointestinal indication requiring hospitalisation. Severe hypertriglyceridaemia (HTG) is the third most common aetiology of AP (HTGAP), with a complication rate and severity that are higher than those of other aetiologies (non-HTGAP). The aim of this st...

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Autores principales: Dancu, Greta, Bende, Felix, Danila, Mirela, Sirli, Roxana, Popescu, Alina, Tarta, Cristi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028994/
https://www.ncbi.nlm.nih.gov/pubmed/35453916
http://dx.doi.org/10.3390/diagnostics12040868
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author Dancu, Greta
Bende, Felix
Danila, Mirela
Sirli, Roxana
Popescu, Alina
Tarta, Cristi
author_facet Dancu, Greta
Bende, Felix
Danila, Mirela
Sirli, Roxana
Popescu, Alina
Tarta, Cristi
author_sort Dancu, Greta
collection PubMed
description Acute pancreatitis (AP) is the most common gastrointestinal indication requiring hospitalisation. Severe hypertriglyceridaemia (HTG) is the third most common aetiology of AP (HTGAP), with a complication rate and severity that are higher than those of other aetiologies (non-HTGAP). The aim of this study was to evaluate the supposedly higher complication rate of HTGAP compared to non-HTGAP. The secondary objectives were to find different biomarkers for predicting a severe form. This was a retrospective study that included patients admitted with AP in a tertiary department of gastroenterology and hepatology. The patients were divided into two groups: HTGAP and non-HTGAP. We searched for differences regarding age, gender, the presence of diabetes mellitus (DM), the severity of the disease, the types of complications and predictive biomarkers for severity, hospital stay and mortality. A total of 262 patients were included, and 11% (30/262) of the patients had HTGAP. The mean ages were 44.4 ± 9.2 in the HTGAP group and 58.2 ± 17.1 in the non-HTGAP group, p < 0.0001. Male gender was predominant in both groups, at 76% (23/30) in the HTGAP group vs. 54% (126/232) in non-HTGAP, p = 0.02; 53% (16/30) presented with DM vs. 18% (42/232), p < 0.0001. The patients with HTG presented higher CRP 48 h after admission: 207 mg/dL ± 3 mg/dL vs. non-HTGAP 103 mg/dL ± 107 mg/dL, p < 0.0001. Among the patients with HTGAP, there were 60% (18/30) with moderately severe forms vs. 30% (71/232), p = 0.001, and 16% (5/30) SAP vs. 11% (27/232) in non-HTGAP, p = 0.4 Among the predictive markers, only haematocrit (HT) and blood urea nitrogen (BUN) had AUCs > 0.8. According to a multiple regression analysis, only BUN 48 h was independently associated with the development of SAP (p = 0.05). Diabetes mellitus increased the risk of developing severe acute pancreatitis (OR: 1.3; 95% CI: 0.1963–9.7682; p = 0.7). In our cohort, HTGAP more frequently had local complications compared with non-HTGAP. A more severe inflammatory syndrome seemed to be associated with this aetiology; the best predictive markers for complicated forms of HTGAP were BUN 48 h and HT 48 h.
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spelling pubmed-90289942022-04-23 Hypertriglyceridaemia-Induced Acute Pancreatitis: A Different Disease Phenotype Dancu, Greta Bende, Felix Danila, Mirela Sirli, Roxana Popescu, Alina Tarta, Cristi Diagnostics (Basel) Article Acute pancreatitis (AP) is the most common gastrointestinal indication requiring hospitalisation. Severe hypertriglyceridaemia (HTG) is the third most common aetiology of AP (HTGAP), with a complication rate and severity that are higher than those of other aetiologies (non-HTGAP). The aim of this study was to evaluate the supposedly higher complication rate of HTGAP compared to non-HTGAP. The secondary objectives were to find different biomarkers for predicting a severe form. This was a retrospective study that included patients admitted with AP in a tertiary department of gastroenterology and hepatology. The patients were divided into two groups: HTGAP and non-HTGAP. We searched for differences regarding age, gender, the presence of diabetes mellitus (DM), the severity of the disease, the types of complications and predictive biomarkers for severity, hospital stay and mortality. A total of 262 patients were included, and 11% (30/262) of the patients had HTGAP. The mean ages were 44.4 ± 9.2 in the HTGAP group and 58.2 ± 17.1 in the non-HTGAP group, p < 0.0001. Male gender was predominant in both groups, at 76% (23/30) in the HTGAP group vs. 54% (126/232) in non-HTGAP, p = 0.02; 53% (16/30) presented with DM vs. 18% (42/232), p < 0.0001. The patients with HTG presented higher CRP 48 h after admission: 207 mg/dL ± 3 mg/dL vs. non-HTGAP 103 mg/dL ± 107 mg/dL, p < 0.0001. Among the patients with HTGAP, there were 60% (18/30) with moderately severe forms vs. 30% (71/232), p = 0.001, and 16% (5/30) SAP vs. 11% (27/232) in non-HTGAP, p = 0.4 Among the predictive markers, only haematocrit (HT) and blood urea nitrogen (BUN) had AUCs > 0.8. According to a multiple regression analysis, only BUN 48 h was independently associated with the development of SAP (p = 0.05). Diabetes mellitus increased the risk of developing severe acute pancreatitis (OR: 1.3; 95% CI: 0.1963–9.7682; p = 0.7). In our cohort, HTGAP more frequently had local complications compared with non-HTGAP. A more severe inflammatory syndrome seemed to be associated with this aetiology; the best predictive markers for complicated forms of HTGAP were BUN 48 h and HT 48 h. MDPI 2022-03-31 /pmc/articles/PMC9028994/ /pubmed/35453916 http://dx.doi.org/10.3390/diagnostics12040868 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dancu, Greta
Bende, Felix
Danila, Mirela
Sirli, Roxana
Popescu, Alina
Tarta, Cristi
Hypertriglyceridaemia-Induced Acute Pancreatitis: A Different Disease Phenotype
title Hypertriglyceridaemia-Induced Acute Pancreatitis: A Different Disease Phenotype
title_full Hypertriglyceridaemia-Induced Acute Pancreatitis: A Different Disease Phenotype
title_fullStr Hypertriglyceridaemia-Induced Acute Pancreatitis: A Different Disease Phenotype
title_full_unstemmed Hypertriglyceridaemia-Induced Acute Pancreatitis: A Different Disease Phenotype
title_short Hypertriglyceridaemia-Induced Acute Pancreatitis: A Different Disease Phenotype
title_sort hypertriglyceridaemia-induced acute pancreatitis: a different disease phenotype
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028994/
https://www.ncbi.nlm.nih.gov/pubmed/35453916
http://dx.doi.org/10.3390/diagnostics12040868
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