Cargando…

Rectovaginal Colonization with Serotypes of Group B Streptococci with Reduced Penicillin Susceptibility among Pregnant Women in León, Nicaragua

Group B Streptococci (GBS) are important causes of neonatal sepsis and meningitis globally. To elucidate the potential benefits of maternal GBS vaccines, data is needed on the epidemiology of maternal GBS rectovaginal colonization, distribution of serotypes, and resistance to intrapartum antibiotic...

Descripción completa

Detalles Bibliográficos
Autores principales: Alemán, Teresa, Vielot, Nadja A., Herrera, Roberto, Velasquez, Reymundo, Berrios, Tatiana, Toval-Ruíz, Christian, Téllez, Evert, Herrera, Andres, Aguilar, Samir, Becker-Dreps, Sylvia, French, Neil, Vilchez, Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029029/
https://www.ncbi.nlm.nih.gov/pubmed/35456090
http://dx.doi.org/10.3390/pathogens11040415
_version_ 1784691775097536512
author Alemán, Teresa
Vielot, Nadja A.
Herrera, Roberto
Velasquez, Reymundo
Berrios, Tatiana
Toval-Ruíz, Christian
Téllez, Evert
Herrera, Andres
Aguilar, Samir
Becker-Dreps, Sylvia
French, Neil
Vilchez, Samuel
author_facet Alemán, Teresa
Vielot, Nadja A.
Herrera, Roberto
Velasquez, Reymundo
Berrios, Tatiana
Toval-Ruíz, Christian
Téllez, Evert
Herrera, Andres
Aguilar, Samir
Becker-Dreps, Sylvia
French, Neil
Vilchez, Samuel
author_sort Alemán, Teresa
collection PubMed
description Group B Streptococci (GBS) are important causes of neonatal sepsis and meningitis globally. To elucidate the potential benefits of maternal GBS vaccines, data is needed on the epidemiology of maternal GBS rectovaginal colonization, distribution of serotypes, and resistance to intrapartum antibiotic prophylaxis (IAP). We collected rectal and vaginal samples from 305 pregnant women in León, Nicaragua between 35 and 40 weeks gestation. Samples were cultured for GBS and confirmed using latex agglutination. GBS isolates underwent serotyping by quantitative polymerase chain reaction, and antimicrobial susceptibility testing by disk diffusion and microdilution following Clinical Laboratory Standard Institute guidelines. Sixty-three women (20.7%) were colonized with GBS in either the rectum or the vagina. Of 91 GBS isolates collected from positive cultures, most were serotypes II (28.6%), Ia (27.5%), and III (20.9%). Most GBS isolates (52.9%) were resistant to penicillin, the first-line prophylactic antibiotic. Penicillin resistance was highly correlated with resistance to vancomycin, ceftriaxone, and meropenem. The results of our study suggest that one-fifth of pregnant women in the urban area of León, Nicaragua are colonized with GBS and risk transmitting GBS to their offspring during labor. High resistance to commonly available antibiotics in the region suggests that prophylactic maternal GBS vaccination would be an effective alternative to IAP.
format Online
Article
Text
id pubmed-9029029
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-90290292022-04-23 Rectovaginal Colonization with Serotypes of Group B Streptococci with Reduced Penicillin Susceptibility among Pregnant Women in León, Nicaragua Alemán, Teresa Vielot, Nadja A. Herrera, Roberto Velasquez, Reymundo Berrios, Tatiana Toval-Ruíz, Christian Téllez, Evert Herrera, Andres Aguilar, Samir Becker-Dreps, Sylvia French, Neil Vilchez, Samuel Pathogens Article Group B Streptococci (GBS) are important causes of neonatal sepsis and meningitis globally. To elucidate the potential benefits of maternal GBS vaccines, data is needed on the epidemiology of maternal GBS rectovaginal colonization, distribution of serotypes, and resistance to intrapartum antibiotic prophylaxis (IAP). We collected rectal and vaginal samples from 305 pregnant women in León, Nicaragua between 35 and 40 weeks gestation. Samples were cultured for GBS and confirmed using latex agglutination. GBS isolates underwent serotyping by quantitative polymerase chain reaction, and antimicrobial susceptibility testing by disk diffusion and microdilution following Clinical Laboratory Standard Institute guidelines. Sixty-three women (20.7%) were colonized with GBS in either the rectum or the vagina. Of 91 GBS isolates collected from positive cultures, most were serotypes II (28.6%), Ia (27.5%), and III (20.9%). Most GBS isolates (52.9%) were resistant to penicillin, the first-line prophylactic antibiotic. Penicillin resistance was highly correlated with resistance to vancomycin, ceftriaxone, and meropenem. The results of our study suggest that one-fifth of pregnant women in the urban area of León, Nicaragua are colonized with GBS and risk transmitting GBS to their offspring during labor. High resistance to commonly available antibiotics in the region suggests that prophylactic maternal GBS vaccination would be an effective alternative to IAP. MDPI 2022-03-29 /pmc/articles/PMC9029029/ /pubmed/35456090 http://dx.doi.org/10.3390/pathogens11040415 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alemán, Teresa
Vielot, Nadja A.
Herrera, Roberto
Velasquez, Reymundo
Berrios, Tatiana
Toval-Ruíz, Christian
Téllez, Evert
Herrera, Andres
Aguilar, Samir
Becker-Dreps, Sylvia
French, Neil
Vilchez, Samuel
Rectovaginal Colonization with Serotypes of Group B Streptococci with Reduced Penicillin Susceptibility among Pregnant Women in León, Nicaragua
title Rectovaginal Colonization with Serotypes of Group B Streptococci with Reduced Penicillin Susceptibility among Pregnant Women in León, Nicaragua
title_full Rectovaginal Colonization with Serotypes of Group B Streptococci with Reduced Penicillin Susceptibility among Pregnant Women in León, Nicaragua
title_fullStr Rectovaginal Colonization with Serotypes of Group B Streptococci with Reduced Penicillin Susceptibility among Pregnant Women in León, Nicaragua
title_full_unstemmed Rectovaginal Colonization with Serotypes of Group B Streptococci with Reduced Penicillin Susceptibility among Pregnant Women in León, Nicaragua
title_short Rectovaginal Colonization with Serotypes of Group B Streptococci with Reduced Penicillin Susceptibility among Pregnant Women in León, Nicaragua
title_sort rectovaginal colonization with serotypes of group b streptococci with reduced penicillin susceptibility among pregnant women in león, nicaragua
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029029/
https://www.ncbi.nlm.nih.gov/pubmed/35456090
http://dx.doi.org/10.3390/pathogens11040415
work_keys_str_mv AT alemanteresa rectovaginalcolonizationwithserotypesofgroupbstreptococciwithreducedpenicillinsusceptibilityamongpregnantwomeninleonnicaragua
AT vielotnadjaa rectovaginalcolonizationwithserotypesofgroupbstreptococciwithreducedpenicillinsusceptibilityamongpregnantwomeninleonnicaragua
AT herreraroberto rectovaginalcolonizationwithserotypesofgroupbstreptococciwithreducedpenicillinsusceptibilityamongpregnantwomeninleonnicaragua
AT velasquezreymundo rectovaginalcolonizationwithserotypesofgroupbstreptococciwithreducedpenicillinsusceptibilityamongpregnantwomeninleonnicaragua
AT berriostatiana rectovaginalcolonizationwithserotypesofgroupbstreptococciwithreducedpenicillinsusceptibilityamongpregnantwomeninleonnicaragua
AT tovalruizchristian rectovaginalcolonizationwithserotypesofgroupbstreptococciwithreducedpenicillinsusceptibilityamongpregnantwomeninleonnicaragua
AT tellezevert rectovaginalcolonizationwithserotypesofgroupbstreptococciwithreducedpenicillinsusceptibilityamongpregnantwomeninleonnicaragua
AT herreraandres rectovaginalcolonizationwithserotypesofgroupbstreptococciwithreducedpenicillinsusceptibilityamongpregnantwomeninleonnicaragua
AT aguilarsamir rectovaginalcolonizationwithserotypesofgroupbstreptococciwithreducedpenicillinsusceptibilityamongpregnantwomeninleonnicaragua
AT beckerdrepssylvia rectovaginalcolonizationwithserotypesofgroupbstreptococciwithreducedpenicillinsusceptibilityamongpregnantwomeninleonnicaragua
AT frenchneil rectovaginalcolonizationwithserotypesofgroupbstreptococciwithreducedpenicillinsusceptibilityamongpregnantwomeninleonnicaragua
AT vilchezsamuel rectovaginalcolonizationwithserotypesofgroupbstreptococciwithreducedpenicillinsusceptibilityamongpregnantwomeninleonnicaragua