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COVID-19 Neutralizing Antibodies in Breast Milk of Mothers Vaccinated with Three Different Vaccines in Mexico

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused the largest pandemic of this century, and all aspects of this virus are being studied. The efforts to mitigate the negative effects associated with the SARS-CoV-2 pandemic have culminated in the development of several vaccines t...

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Autores principales: Cabanillas-Bernal, Olivia, Cervantes-Luevano, Karla, Flores-Acosta, Gonzalo Isai, Bernáldez-Sarabia, Johanna, Licea-Navarro, Alexei F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029061/
https://www.ncbi.nlm.nih.gov/pubmed/35455378
http://dx.doi.org/10.3390/vaccines10040629
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author Cabanillas-Bernal, Olivia
Cervantes-Luevano, Karla
Flores-Acosta, Gonzalo Isai
Bernáldez-Sarabia, Johanna
Licea-Navarro, Alexei F.
author_facet Cabanillas-Bernal, Olivia
Cervantes-Luevano, Karla
Flores-Acosta, Gonzalo Isai
Bernáldez-Sarabia, Johanna
Licea-Navarro, Alexei F.
author_sort Cabanillas-Bernal, Olivia
collection PubMed
description Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused the largest pandemic of this century, and all aspects of this virus are being studied. The efforts to mitigate the negative effects associated with the SARS-CoV-2 pandemic have culminated in the development of several vaccines that are effective and safe for use to the general population. However, one aspect that remains relatively underexplored is the efficacy of different vaccines technologies (mRNA and Adenovirus) in providing passive immunity to infants through breastmilk of vaccinated mothers, and whether the antibodies passed through breast milk are functional. In this study, using a Micro-neutralization assay, we evaluate the presence of neutralizing antibodies in breast milk of lactating mothers vaccinated against SARS-CoV-2 with the Pfizer-BioNtech, Johnson & Johnson (J&J)/Janssen, and CanSino Biologics vaccines. Our results show the greatest neutralizing effect in breast milk from mothers vaccinated with Pfizer, followed by mothers vaccinated with J&J. CanSino vaccinations yielded the breast milk with the least neutralizing effects. The results found in this study relating to the neutralizing capacity of breast milk against SARS-CoV-2 highlight the importance of corresponding health authorities recommending vaccination to lactating mothers and of the continuance of breastfeeding to infants due to the potential health benefits.
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spelling pubmed-90290612022-04-23 COVID-19 Neutralizing Antibodies in Breast Milk of Mothers Vaccinated with Three Different Vaccines in Mexico Cabanillas-Bernal, Olivia Cervantes-Luevano, Karla Flores-Acosta, Gonzalo Isai Bernáldez-Sarabia, Johanna Licea-Navarro, Alexei F. Vaccines (Basel) Brief Report Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused the largest pandemic of this century, and all aspects of this virus are being studied. The efforts to mitigate the negative effects associated with the SARS-CoV-2 pandemic have culminated in the development of several vaccines that are effective and safe for use to the general population. However, one aspect that remains relatively underexplored is the efficacy of different vaccines technologies (mRNA and Adenovirus) in providing passive immunity to infants through breastmilk of vaccinated mothers, and whether the antibodies passed through breast milk are functional. In this study, using a Micro-neutralization assay, we evaluate the presence of neutralizing antibodies in breast milk of lactating mothers vaccinated against SARS-CoV-2 with the Pfizer-BioNtech, Johnson & Johnson (J&J)/Janssen, and CanSino Biologics vaccines. Our results show the greatest neutralizing effect in breast milk from mothers vaccinated with Pfizer, followed by mothers vaccinated with J&J. CanSino vaccinations yielded the breast milk with the least neutralizing effects. The results found in this study relating to the neutralizing capacity of breast milk against SARS-CoV-2 highlight the importance of corresponding health authorities recommending vaccination to lactating mothers and of the continuance of breastfeeding to infants due to the potential health benefits. MDPI 2022-04-18 /pmc/articles/PMC9029061/ /pubmed/35455378 http://dx.doi.org/10.3390/vaccines10040629 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Cabanillas-Bernal, Olivia
Cervantes-Luevano, Karla
Flores-Acosta, Gonzalo Isai
Bernáldez-Sarabia, Johanna
Licea-Navarro, Alexei F.
COVID-19 Neutralizing Antibodies in Breast Milk of Mothers Vaccinated with Three Different Vaccines in Mexico
title COVID-19 Neutralizing Antibodies in Breast Milk of Mothers Vaccinated with Three Different Vaccines in Mexico
title_full COVID-19 Neutralizing Antibodies in Breast Milk of Mothers Vaccinated with Three Different Vaccines in Mexico
title_fullStr COVID-19 Neutralizing Antibodies in Breast Milk of Mothers Vaccinated with Three Different Vaccines in Mexico
title_full_unstemmed COVID-19 Neutralizing Antibodies in Breast Milk of Mothers Vaccinated with Three Different Vaccines in Mexico
title_short COVID-19 Neutralizing Antibodies in Breast Milk of Mothers Vaccinated with Three Different Vaccines in Mexico
title_sort covid-19 neutralizing antibodies in breast milk of mothers vaccinated with three different vaccines in mexico
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029061/
https://www.ncbi.nlm.nih.gov/pubmed/35455378
http://dx.doi.org/10.3390/vaccines10040629
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