Naphtho-Gamma-Pyrones (NγPs) with Obvious Cholesterol Absorption Inhibitory Activity from the Marine-Derived Fungus Aspergillus niger S-48

Eight naphtho-gamma-pyrones (NγPs) (1–8), together with four known biosynthetically related coumarin derivatives (9–12), were isolated from the potato dextrose agar media of a marine-derived fungus Aspergillus niger S-48. Among them, natural compounds 1 and 2 were tentatively subjected to benzohydra...

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Autores principales: Wu, Chang-Zheng, Peng, Xiao-Ping, Li, Gang, Wang, Qi, Lou, Hong-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029069/
https://www.ncbi.nlm.nih.gov/pubmed/35458715
http://dx.doi.org/10.3390/molecules27082514
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author Wu, Chang-Zheng
Peng, Xiao-Ping
Li, Gang
Wang, Qi
Lou, Hong-Xiang
author_facet Wu, Chang-Zheng
Peng, Xiao-Ping
Li, Gang
Wang, Qi
Lou, Hong-Xiang
author_sort Wu, Chang-Zheng
collection PubMed
description Eight naphtho-gamma-pyrones (NγPs) (1–8), together with four known biosynthetically related coumarin derivatives (9–12), were isolated from the potato dextrose agar media of a marine-derived fungus Aspergillus niger S-48. Among them, natural compounds 1 and 2 were tentatively subjected to benzohydrazide reaction to evaluate the importance of pyran rings in NγPs. Their structures were elucidated by extensive 1D and 2D NMR spectroscopic data and MS spectra. Compounds 1–4 showed obvious activity for reducing cholesterol absorption verging on ezetimibe. This work highlighted the potential of natural NγPs as NPC1L1 inhibitors.
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spelling pubmed-90290692022-04-23 Naphtho-Gamma-Pyrones (NγPs) with Obvious Cholesterol Absorption Inhibitory Activity from the Marine-Derived Fungus Aspergillus niger S-48 Wu, Chang-Zheng Peng, Xiao-Ping Li, Gang Wang, Qi Lou, Hong-Xiang Molecules Article Eight naphtho-gamma-pyrones (NγPs) (1–8), together with four known biosynthetically related coumarin derivatives (9–12), were isolated from the potato dextrose agar media of a marine-derived fungus Aspergillus niger S-48. Among them, natural compounds 1 and 2 were tentatively subjected to benzohydrazide reaction to evaluate the importance of pyran rings in NγPs. Their structures were elucidated by extensive 1D and 2D NMR spectroscopic data and MS spectra. Compounds 1–4 showed obvious activity for reducing cholesterol absorption verging on ezetimibe. This work highlighted the potential of natural NγPs as NPC1L1 inhibitors. MDPI 2022-04-13 /pmc/articles/PMC9029069/ /pubmed/35458715 http://dx.doi.org/10.3390/molecules27082514 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Chang-Zheng
Peng, Xiao-Ping
Li, Gang
Wang, Qi
Lou, Hong-Xiang
Naphtho-Gamma-Pyrones (NγPs) with Obvious Cholesterol Absorption Inhibitory Activity from the Marine-Derived Fungus Aspergillus niger S-48
title Naphtho-Gamma-Pyrones (NγPs) with Obvious Cholesterol Absorption Inhibitory Activity from the Marine-Derived Fungus Aspergillus niger S-48
title_full Naphtho-Gamma-Pyrones (NγPs) with Obvious Cholesterol Absorption Inhibitory Activity from the Marine-Derived Fungus Aspergillus niger S-48
title_fullStr Naphtho-Gamma-Pyrones (NγPs) with Obvious Cholesterol Absorption Inhibitory Activity from the Marine-Derived Fungus Aspergillus niger S-48
title_full_unstemmed Naphtho-Gamma-Pyrones (NγPs) with Obvious Cholesterol Absorption Inhibitory Activity from the Marine-Derived Fungus Aspergillus niger S-48
title_short Naphtho-Gamma-Pyrones (NγPs) with Obvious Cholesterol Absorption Inhibitory Activity from the Marine-Derived Fungus Aspergillus niger S-48
title_sort naphtho-gamma-pyrones (nγps) with obvious cholesterol absorption inhibitory activity from the marine-derived fungus aspergillus niger s-48
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029069/
https://www.ncbi.nlm.nih.gov/pubmed/35458715
http://dx.doi.org/10.3390/molecules27082514
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