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Regulation of p27 (Kip1) by Ubiquitin E3 Ligase RNF6

The cyclin-dependent kinase inhibitor p27 (Kip1) is an important regulator of the G1/S checkpoint. It is degraded by the SCF-SKP2 complex in late G1 thereby allowing cells to progress to the S phase. Here we investigated the role of the E3 ubiquitin ligase RNF6 (Ring Finger Protein 6) in cell cycle...

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Detalles Bibliográficos
Autores principales:	Deshmukh, Dhanraj, Xu, Jin, Yang, Xi, Shimelis, Hermela, Fang, Shengyun, Qiu, Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029106/ https://www.ncbi.nlm.nih.gov/pubmed/35456636 http://dx.doi.org/10.3390/pharmaceutics14040802

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