Mitochondrial-Targeted Therapies Require Mitophagy to Prevent Oxidative Stress Induced by SOD2 Inactivation in Hypertrophied Cardiomyocytes

Heart failure, mostly associated with cardiac hypertrophy, is a major cause of illness and death. Oxidative stress causes accumulation of reactive oxygen species (ROS), leading to mitochondrial dysfunction, suggesting that mitochondria-targeted therapies could be effective in this context. The purpo...

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Detalles Bibliográficos
Autores principales: Peugnet, Victoriane, Chwastyniak, Maggy, Mulder, Paul, Lancel, Steve, Bultot, Laurent, Fourny, Natacha, Renguet, Edith, Bugger, Heiko, Beseme, Olivia, Loyens, Anne, Heyse, Wilfried, Richard, Vincent, Amouyel, Philippe, Bertrand, Luc, Pinet, Florence, Dubois-Deruy, Emilie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029275/
https://www.ncbi.nlm.nih.gov/pubmed/35453408
http://dx.doi.org/10.3390/antiox11040723

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