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Total Synthesis of Eliglustat via Diastereoselective Amination of Chiral para-Methoxycinnamyl Benzyl Ether

Eliglustat (Cerdelga(®), Genzyme Corp. Cambridge, MA, USA) is an approved drug for a non-neurological type of Gaucher disease. Herein, we describe the total synthesis of eliglustat 1 starting from readily available 1,4-benzodioxan-6-carbaldehyde via Sharpless asymmetric dihydroxylation and diastereo...

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Detalles Bibliográficos
Autores principales:	Kong, Younggyu, Boggu, Pulla Reddy, Park, Gi Min, Kim, Yeon Su, An, Seong Hwan, Kim, In Su, Jung, Young Hoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029353/ https://www.ncbi.nlm.nih.gov/pubmed/35458801 http://dx.doi.org/10.3390/molecules27082603

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