GBA Variants and Parkinson Disease: Mechanisms and Treatments

The GBA gene encodes for the lysosomal enzyme glucocerebrosidase (GCase), which maintains glycosphingolipid homeostasis. Approximately 5–15% of PD patients have mutations in the GBA gene, making it numerically the most important genetic risk factor for Parkinson disease (PD). Clinically, GBA-associa...

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Detalles Bibliográficos
Autores principales: Smith, Laura, Schapira, Anthony H. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029385/
https://www.ncbi.nlm.nih.gov/pubmed/35455941
http://dx.doi.org/10.3390/cells11081261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029385/
https://www.ncbi.nlm.nih.gov/pubmed/35455941
http://dx.doi.org/10.3390/cells11081261

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