Cargando…

A Consistent Protocol Reveals a Large Heterogeneity in the Biological Effectiveness of Proton and Carbon-Ion Beams for Various Sarcoma and Normal-Tissue-Derived Cell Lines

SIMPLE SUMMARY: Using a consistent experimental protocol, we found a large heterogeneity in the relative biological effectiveness (RBE) values of both proton and carbon-ion beams in various sarcomas and normal-tissue-derived cell lines. Our data suggest that proton beam therapy may be more beneficia...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yagi, Masashi, Takahashi, Yutaka, Minami, Kazumasa, Matsuura, Taeko, Nam, Jin-Min, Onodera, Yasuhito, Akagi, Takashi, Maeda, Takuya, Okimoto, Tomoaki, Shirato, Hiroki, Ogawa, Kazuhiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029457/ https://www.ncbi.nlm.nih.gov/pubmed/35454915 http://dx.doi.org/10.3390/cancers14082009

Ejemplares similares

Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe
por: Onodera, Yasuhito, et al.
Publicado: (2018)

A Nucleoside Anticancer Drug, 1-(3-C-Ethynyl-β-D-Ribo-Pentofuranosyl)Cytosine, Induces Depth-Dependent Enhancement of Tumor Cell Death in Spread-Out Bragg Peak (SOBP) of Proton Beam
por: Maeda, Kenichiro, et al.
Publicado: (2016)

Radiobiological effects of flattening filter–free photon beams on A549 non-small-cell lung cancer cells
por: Nakano, Hisashi, et al.
Publicado: (2018)

Evaluation of the relative biological effectiveness of spot-scanning proton irradiation in vitro
por: Maeda, Kenichiro, et al.
Publicado: (2016)

Rab5c promotes AMAP1–PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion
por: Onodera, Yasuhito, et al.
Publicado: (2012)

A Proton Beam Therapy System Dedicated to Spot-Scanning Increases Accuracy with Moving Tumors by Real-Time Imaging and Gating and Reduces Equipment Size
por: Shimizu, Shinichi, et al.
Publicado: (2014)

Dynamic gating window technique for the reduction of dosimetric error in respiratory‐gated spot‐scanning particle therapy: An initial phantom study using patient tumor trajectory data
por: Miyamoto, Naoki, et al.
Publicado: (2020)

A novel range-verification method using ionoacoustic wave generated from spherical gold markers for particle-beam therapy: a simulation study
por: Takayanagi, Taisuke, et al.
Publicado: (2019)

Lysosomal trafficking mediated by Arl8b and BORC promotes invasion of cancer cells that survive radiation
por: Wu, Ping-Hsiu, et al.
Publicado: (2020)

Physical and biological beam modeling for carbon beam scanning at Osaka Heavy Ion Therapy Center
por: Fujitaka, Shinichiro, et al.
Publicado: (2021)

Prediction of target position from multiple fiducial markers by partial least squares regression in real-time tumor-tracking radiation therapy
por: Ukon, Kanako, et al.
Publicado: (2021)

Intraneural synovial sarcoma of the tibial nerve
por: Hashimoto, Kazuhiko, et al.
Publicado: (2018)

Surgical management of sarcoma in adolescent and young adult patients
por: Hashimoto, Kazuhiko, et al.
Publicado: (2020)

Development of a wavelength-separated type scintillator with optical fiber (SOF) dosimeter to compensate for the Cerenkov radiation effect
por: Ishikawa, Masayori, et al.
Publicado: (2015)

Development of hepatocellular carcinoma from various phases of chronic hepatitis B virus infection
por: Suzuki, Takanori, et al.
Publicado: (2021)

A simulation study on the dosimetric benefit of real-time motion compensation in spot-scanning proton therapy for prostate
por: Fujii, Yusuke, et al.
Publicado: (2017)

Carbon ion irradiation enhances the antitumor efficacy of dual immune checkpoint blockade therapy both for local and distant sites in murine osteosarcoma
por: Takahashi, Yutaka, et al.
Publicado: (2019)

Lambda-Carrageenan Enhances the Effects of Radiation Therapy in Cancer Treatment by Suppressing Cancer Cell Invasion and Metastasis through Racgap1 Inhibition
por: Wu, Ping-Hsiu, et al.
Publicado: (2019)

Characterizing inflammatory markers in highly aggressive soft tissue sarcomas
por: Hashimoto, Kazuhiko, et al.
Publicado: (2022)

Clinical features and outcomes of primary bone and soft tissue sarcomas in adolescents and young adults
por: Hashimoto, Kazuhiko, et al.
Publicado: (2020)

Radiation Dose Escalation Is Crucial in Anti-CTLA-4 Antibody Therapy to Enhance Local and Distant Antitumor Effect in Murine Osteosarcoma
por: Takenaka, Wataru, et al.
Publicado: (2020)

Characterization of PD-1/PD-L1 immune checkpoint expression in soft tissue sarcomas
por: Hashimoto, Kazuhiko, et al.
Publicado: (2021)

A motion-compensated image filter for low-dose fluoroscopy in a real-time tumor-tracking radiotherapy system
por: Miyamoto, Naoki, et al.
Publicado: (2015)

Proton beam therapy for bone sarcomas of the skull base and spine: A retrospective nationwide multicenter study in Japan
por: Demizu, Yusuke, et al.
Publicado: (2017)

Visible-light-driven CO(2) reduction on a hybrid photocatalyst consisting of a Ru(ii) binuclear complex and a Ag-loaded TaON in aqueous solutions
por: Nakada, Akinobu, et al.
Publicado: (2016)

Inflammatory Undifferentiated Pleomorphic Sarcoma Mimicking Bacteremia in an Elderly Patient: A Case Report
por: Hashimoto, Kazuhiko, et al.
Publicado: (2021)

Validation of robust radiobiological optimization algorithms based on the mixed beam model for intensity-modulated carbon-ion therapy
por: Yagi, Masashi, et al.
Publicado: (2023)

Targeting integrins with RGD-conjugated gold nanoparticles in radiotherapy decreases the invasive activity of breast cancer cells
por: Wu, Ping-Hsiu, et al.
Publicado: (2017)

Rab27b contributes to radioresistance and exerts a paracrine effect via epiregulin in glioblastoma
por: Nishioka, Soichiro, et al.
Publicado: (2020)

Olfactory neuroblastoma: the long-term outcome and late toxicity of multimodal therapy including radiotherapy based on treatment planning using computed tomography
por: Mori, Takashi, et al.
Publicado: (2015)

Radiation enhanced the local and distant anti-tumor efficacy in dual immune checkpoint blockade therapy in osteosarcoma
por: Takahashi, Yutaka, et al.
Publicado: (2017)

High Dose Local Photon Irradiation Is Crucial in Anti-CTLA-4 Antibody Therapy to Enhance the Abscopal Response in a Murine Pancreatic Carcinoma Model
por: Yamamoto, Junya, et al.
Publicado: (2022)

Clinicopathological Assessment of Cancer/Testis Antigens NY-ESO-1 and MAGE-A4 in Highly Aggressive Soft Tissue Sarcomas
por: Hashimoto, Kazuhiko, et al.
Publicado: (2022)

Exploring the Tumor-Suppressing Potential of PSCA in Pancreatic Ductal Adenocarcinoma
por: Li, Kexin, et al.
Publicado: (2023)

Carbon ion radiotherapy for desmoid tumor of the abdominal wall: a case report
por: Nagata, Takuya, et al.
Publicado: (2016)

Erratum to: Carbon ion radiotherapy for desmoid tumor of the abdominal wall: a case report
por: Nagata, Takuya, et al.
Publicado: (2017)

Surgical, endovascular, and hybrid treatment of deep femoral artery aneurysm: Three case reports
por: Moriuchi, Hiroki, et al.
Publicado: (2023)

Potential benefits of adaptive intensity‐modulated proton therapy in nasopharyngeal carcinomas
por: Minatogawa, Hideki, et al.
Publicado: (2020)

Validation of dose distribution for liver tumors treated with real-time-image gated spot-scanning proton therapy by log data based dose reconstruction
por: Yamada, Takahiro, et al.
Publicado: (2021)

Radiation therapy enhances systemic antitumor efficacy in PD-L1 therapy regardless of sequence of radiation in murine osteosarcoma
por: Katsuki, Shohei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ihijq5echm35uf08g4plqvtru0