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Markers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgery
Background: Aortic valve sclerosis (AVS), mitral valve sclerosis (MVS), remodeling of major arteries, and increased pericardial fat are associated with subclinical atherosclerosis. We assessed these markers of atherosclerosis in severely obese patients before and 1 year after bariatric surgery. Meth...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029498/ https://www.ncbi.nlm.nih.gov/pubmed/35456330 http://dx.doi.org/10.3390/jcm11082237 |
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author | Kovac, Nina Grymyr, Lisa M. D. Gerdts, Eva Nadirpour, Saied Nedrebø, Bjørn G. Hjertaas, Johannes J. Matre, Knut Cramariuc, Dana |
author_facet | Kovac, Nina Grymyr, Lisa M. D. Gerdts, Eva Nadirpour, Saied Nedrebø, Bjørn G. Hjertaas, Johannes J. Matre, Knut Cramariuc, Dana |
author_sort | Kovac, Nina |
collection | PubMed |
description | Background: Aortic valve sclerosis (AVS), mitral valve sclerosis (MVS), remodeling of major arteries, and increased pericardial fat are associated with subclinical atherosclerosis. We assessed these markers of atherosclerosis in severely obese patients before and 1 year after bariatric surgery. Methods: Eighty-seven severely obese patients (43 ± 10 years, preoperative body mass index [BMI] 41.8 ± 5 kg/m(2)) underwent echocardiography before and 1 year after Roux-en-Y bypass surgery in the FatWest (Bariatric Surgery on the West Coast of Norway) study. We measured the end-diastolic aortic wall thickness (AWT), pericardial fat thickness at the right ventricular free wall, and AVS/MVS based on combined aortic leaflet thickness and hyperechoic valve lesions. Results: Postoperatively, patients experienced a reduction of 12.9 ± 3.9 kg/m(2) in BMI, 0.5 ± 1.9 mm in AWT, 2.6 ± 2.3 mm in pericardial fat, and 45%/53% in AVS/MVS (p < 0.05). In multivariate regression analyses with adjustment for clinical and hemodynamic variables, less pericardial fat reduction was associated with male sex and higher 1-year blood pressure and BMI, and less AWT-reduction with higher age and 1-year BMI (p < 0.05). Persistent AVS and MVS were related to higher 1-year BMI and more advanced valve sclerosis preoperatively (p < 0.05). Conclusions: Markers of subclinical atherosclerosis decreases significantly 1 year after bariatric surgery, particularly in younger patients that achieve a BMI < 28 kg/m(2). |
format | Online Article Text |
id | pubmed-9029498 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90294982022-04-23 Markers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgery Kovac, Nina Grymyr, Lisa M. D. Gerdts, Eva Nadirpour, Saied Nedrebø, Bjørn G. Hjertaas, Johannes J. Matre, Knut Cramariuc, Dana J Clin Med Article Background: Aortic valve sclerosis (AVS), mitral valve sclerosis (MVS), remodeling of major arteries, and increased pericardial fat are associated with subclinical atherosclerosis. We assessed these markers of atherosclerosis in severely obese patients before and 1 year after bariatric surgery. Methods: Eighty-seven severely obese patients (43 ± 10 years, preoperative body mass index [BMI] 41.8 ± 5 kg/m(2)) underwent echocardiography before and 1 year after Roux-en-Y bypass surgery in the FatWest (Bariatric Surgery on the West Coast of Norway) study. We measured the end-diastolic aortic wall thickness (AWT), pericardial fat thickness at the right ventricular free wall, and AVS/MVS based on combined aortic leaflet thickness and hyperechoic valve lesions. Results: Postoperatively, patients experienced a reduction of 12.9 ± 3.9 kg/m(2) in BMI, 0.5 ± 1.9 mm in AWT, 2.6 ± 2.3 mm in pericardial fat, and 45%/53% in AVS/MVS (p < 0.05). In multivariate regression analyses with adjustment for clinical and hemodynamic variables, less pericardial fat reduction was associated with male sex and higher 1-year blood pressure and BMI, and less AWT-reduction with higher age and 1-year BMI (p < 0.05). Persistent AVS and MVS were related to higher 1-year BMI and more advanced valve sclerosis preoperatively (p < 0.05). Conclusions: Markers of subclinical atherosclerosis decreases significantly 1 year after bariatric surgery, particularly in younger patients that achieve a BMI < 28 kg/m(2). MDPI 2022-04-16 /pmc/articles/PMC9029498/ /pubmed/35456330 http://dx.doi.org/10.3390/jcm11082237 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kovac, Nina Grymyr, Lisa M. D. Gerdts, Eva Nadirpour, Saied Nedrebø, Bjørn G. Hjertaas, Johannes J. Matre, Knut Cramariuc, Dana Markers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgery |
title | Markers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgery |
title_full | Markers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgery |
title_fullStr | Markers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgery |
title_full_unstemmed | Markers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgery |
title_short | Markers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgery |
title_sort | markers of subclinical atherosclerosis in severe obesity and one year after bariatric surgery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029498/ https://www.ncbi.nlm.nih.gov/pubmed/35456330 http://dx.doi.org/10.3390/jcm11082237 |
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