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Markers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgery

Background: Aortic valve sclerosis (AVS), mitral valve sclerosis (MVS), remodeling of major arteries, and increased pericardial fat are associated with subclinical atherosclerosis. We assessed these markers of atherosclerosis in severely obese patients before and 1 year after bariatric surgery. Meth...

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Autores principales: Kovac, Nina, Grymyr, Lisa M. D., Gerdts, Eva, Nadirpour, Saied, Nedrebø, Bjørn G., Hjertaas, Johannes J., Matre, Knut, Cramariuc, Dana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029498/
https://www.ncbi.nlm.nih.gov/pubmed/35456330
http://dx.doi.org/10.3390/jcm11082237
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author Kovac, Nina
Grymyr, Lisa M. D.
Gerdts, Eva
Nadirpour, Saied
Nedrebø, Bjørn G.
Hjertaas, Johannes J.
Matre, Knut
Cramariuc, Dana
author_facet Kovac, Nina
Grymyr, Lisa M. D.
Gerdts, Eva
Nadirpour, Saied
Nedrebø, Bjørn G.
Hjertaas, Johannes J.
Matre, Knut
Cramariuc, Dana
author_sort Kovac, Nina
collection PubMed
description Background: Aortic valve sclerosis (AVS), mitral valve sclerosis (MVS), remodeling of major arteries, and increased pericardial fat are associated with subclinical atherosclerosis. We assessed these markers of atherosclerosis in severely obese patients before and 1 year after bariatric surgery. Methods: Eighty-seven severely obese patients (43 ± 10 years, preoperative body mass index [BMI] 41.8 ± 5 kg/m(2)) underwent echocardiography before and 1 year after Roux-en-Y bypass surgery in the FatWest (Bariatric Surgery on the West Coast of Norway) study. We measured the end-diastolic aortic wall thickness (AWT), pericardial fat thickness at the right ventricular free wall, and AVS/MVS based on combined aortic leaflet thickness and hyperechoic valve lesions. Results: Postoperatively, patients experienced a reduction of 12.9 ± 3.9 kg/m(2) in BMI, 0.5 ± 1.9 mm in AWT, 2.6 ± 2.3 mm in pericardial fat, and 45%/53% in AVS/MVS (p < 0.05). In multivariate regression analyses with adjustment for clinical and hemodynamic variables, less pericardial fat reduction was associated with male sex and higher 1-year blood pressure and BMI, and less AWT-reduction with higher age and 1-year BMI (p < 0.05). Persistent AVS and MVS were related to higher 1-year BMI and more advanced valve sclerosis preoperatively (p < 0.05). Conclusions: Markers of subclinical atherosclerosis decreases significantly 1 year after bariatric surgery, particularly in younger patients that achieve a BMI < 28 kg/m(2).
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spelling pubmed-90294982022-04-23 Markers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgery Kovac, Nina Grymyr, Lisa M. D. Gerdts, Eva Nadirpour, Saied Nedrebø, Bjørn G. Hjertaas, Johannes J. Matre, Knut Cramariuc, Dana J Clin Med Article Background: Aortic valve sclerosis (AVS), mitral valve sclerosis (MVS), remodeling of major arteries, and increased pericardial fat are associated with subclinical atherosclerosis. We assessed these markers of atherosclerosis in severely obese patients before and 1 year after bariatric surgery. Methods: Eighty-seven severely obese patients (43 ± 10 years, preoperative body mass index [BMI] 41.8 ± 5 kg/m(2)) underwent echocardiography before and 1 year after Roux-en-Y bypass surgery in the FatWest (Bariatric Surgery on the West Coast of Norway) study. We measured the end-diastolic aortic wall thickness (AWT), pericardial fat thickness at the right ventricular free wall, and AVS/MVS based on combined aortic leaflet thickness and hyperechoic valve lesions. Results: Postoperatively, patients experienced a reduction of 12.9 ± 3.9 kg/m(2) in BMI, 0.5 ± 1.9 mm in AWT, 2.6 ± 2.3 mm in pericardial fat, and 45%/53% in AVS/MVS (p < 0.05). In multivariate regression analyses with adjustment for clinical and hemodynamic variables, less pericardial fat reduction was associated with male sex and higher 1-year blood pressure and BMI, and less AWT-reduction with higher age and 1-year BMI (p < 0.05). Persistent AVS and MVS were related to higher 1-year BMI and more advanced valve sclerosis preoperatively (p < 0.05). Conclusions: Markers of subclinical atherosclerosis decreases significantly 1 year after bariatric surgery, particularly in younger patients that achieve a BMI < 28 kg/m(2). MDPI 2022-04-16 /pmc/articles/PMC9029498/ /pubmed/35456330 http://dx.doi.org/10.3390/jcm11082237 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kovac, Nina
Grymyr, Lisa M. D.
Gerdts, Eva
Nadirpour, Saied
Nedrebø, Bjørn G.
Hjertaas, Johannes J.
Matre, Knut
Cramariuc, Dana
Markers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgery
title Markers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgery
title_full Markers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgery
title_fullStr Markers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgery
title_full_unstemmed Markers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgery
title_short Markers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgery
title_sort markers of subclinical atherosclerosis in severe obesity and one year after bariatric surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029498/
https://www.ncbi.nlm.nih.gov/pubmed/35456330
http://dx.doi.org/10.3390/jcm11082237
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