Dosing Colistimethate Every 8 h Results in Higher Plasma Concentrations of Active Colistin Than Every 12-Hourly Dosing without Increase in Nephrotoxicity: A Phase 1 Pharmacokinetics Trial in Healthy Adult Volunteers

Despite its use for decades, pharmacokinetic (PK) and safety studies on colistin are limited. We conducted a phase l, open-label trial to evaluate the safety and PK of multiple doses of intravenous (IV) and aerosolized colistimethate sodium (CMS) administered separately and in combination. In total,...

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Autores principales: Yendewa, George A., Griffiss, John McLeod, Gray, Wesley A., Healen, Amanda, Proskin, Howard M., Fulton, Scott A., O’Riordan, Mary Ann, Hoppel, Charles, Blumer, Jeffrey L., Salata, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029538/
https://www.ncbi.nlm.nih.gov/pubmed/35453240
http://dx.doi.org/10.3390/antibiotics11040490

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