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Serum Allergen-Specific IgE among Pediatric Patients with Primary Immunodeficiency
Background: Allergy is a clinical condition that reflects a deviated function of the immune system. The purpose of this study was to evaluate serum allergen-specific IgE (sIgE) along with clinical manifestations of allergy in patients with diagnosed primary immunodeficiency (PID). Methods: 72 patien...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029572/ https://www.ncbi.nlm.nih.gov/pubmed/35455510 http://dx.doi.org/10.3390/children9040466 |
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author | Pieniawska-Śmiech, Karolina Lewandowicz-Uszyńska, Aleksandra Zemelka-Wiacek, Magdalena Jutel, Marek |
author_facet | Pieniawska-Śmiech, Karolina Lewandowicz-Uszyńska, Aleksandra Zemelka-Wiacek, Magdalena Jutel, Marek |
author_sort | Pieniawska-Śmiech, Karolina |
collection | PubMed |
description | Background: Allergy is a clinical condition that reflects a deviated function of the immune system. The purpose of this study was to evaluate serum allergen-specific IgE (sIgE) along with clinical manifestations of allergy in patients with diagnosed primary immunodeficiency (PID). Methods: 72 patients, aged 1–17 years, diagnosed with PID and hospitalized between July 2020 and February 2021 were included in the study. Blood samples were obtained by venipuncture. sIgE (30 allergens), blood eosinophil count, as well as total IgE and IgG were measured and assessed in relation to a detailed medical examination. Results: Serum sIgE was detected in the blood of 50% of the patients in the study group, which significantly correlated (p < 0.0001) with clinical symptoms of allergy. During the period of the study, 61.1% of the patients showed symptoms of allergy, with 77.27% of them having tested positive for sIgE. The total IgE level was elevated in 18.06% of the patients and correlated with clinical symptoms of allergy (p = 0.004). An elevated total IgE level was not observed in children receiving immunoglobulin replacement therapy. Conclusion: The study showed that serum sIgE and total IgE together might be a plausible diagnostic tool for PID patients. However, for patients receiving immunoglobulin replacement therapy, the assessment of total IgE is not useful. |
format | Online Article Text |
id | pubmed-9029572 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90295722022-04-23 Serum Allergen-Specific IgE among Pediatric Patients with Primary Immunodeficiency Pieniawska-Śmiech, Karolina Lewandowicz-Uszyńska, Aleksandra Zemelka-Wiacek, Magdalena Jutel, Marek Children (Basel) Article Background: Allergy is a clinical condition that reflects a deviated function of the immune system. The purpose of this study was to evaluate serum allergen-specific IgE (sIgE) along with clinical manifestations of allergy in patients with diagnosed primary immunodeficiency (PID). Methods: 72 patients, aged 1–17 years, diagnosed with PID and hospitalized between July 2020 and February 2021 were included in the study. Blood samples were obtained by venipuncture. sIgE (30 allergens), blood eosinophil count, as well as total IgE and IgG were measured and assessed in relation to a detailed medical examination. Results: Serum sIgE was detected in the blood of 50% of the patients in the study group, which significantly correlated (p < 0.0001) with clinical symptoms of allergy. During the period of the study, 61.1% of the patients showed symptoms of allergy, with 77.27% of them having tested positive for sIgE. The total IgE level was elevated in 18.06% of the patients and correlated with clinical symptoms of allergy (p = 0.004). An elevated total IgE level was not observed in children receiving immunoglobulin replacement therapy. Conclusion: The study showed that serum sIgE and total IgE together might be a plausible diagnostic tool for PID patients. However, for patients receiving immunoglobulin replacement therapy, the assessment of total IgE is not useful. MDPI 2022-03-25 /pmc/articles/PMC9029572/ /pubmed/35455510 http://dx.doi.org/10.3390/children9040466 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pieniawska-Śmiech, Karolina Lewandowicz-Uszyńska, Aleksandra Zemelka-Wiacek, Magdalena Jutel, Marek Serum Allergen-Specific IgE among Pediatric Patients with Primary Immunodeficiency |
title | Serum Allergen-Specific IgE among Pediatric Patients with Primary Immunodeficiency |
title_full | Serum Allergen-Specific IgE among Pediatric Patients with Primary Immunodeficiency |
title_fullStr | Serum Allergen-Specific IgE among Pediatric Patients with Primary Immunodeficiency |
title_full_unstemmed | Serum Allergen-Specific IgE among Pediatric Patients with Primary Immunodeficiency |
title_short | Serum Allergen-Specific IgE among Pediatric Patients with Primary Immunodeficiency |
title_sort | serum allergen-specific ige among pediatric patients with primary immunodeficiency |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029572/ https://www.ncbi.nlm.nih.gov/pubmed/35455510 http://dx.doi.org/10.3390/children9040466 |
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