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Estradiol and Estrogen-like Alternative Therapies in Use: The Importance of the Selective and Non-Classical Actions
Estrogen is one of the most important female sex hormones, and is indispensable for reproduction. However, its role is much wider. Among others, due to its neuroprotective effects, estrogen protects the brain against dementia and complications of traumatic injury. Previously, it was used mainly as a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029610/ https://www.ncbi.nlm.nih.gov/pubmed/35453610 http://dx.doi.org/10.3390/biomedicines10040861 |
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author | Farkas, Szidónia Szabó, Adrienn Hegyi, Anita Emőke Török, Bibiána Fazekas, Csilla Lea Ernszt, Dávid Kovács, Tamás Zelena, Dóra |
author_facet | Farkas, Szidónia Szabó, Adrienn Hegyi, Anita Emőke Török, Bibiána Fazekas, Csilla Lea Ernszt, Dávid Kovács, Tamás Zelena, Dóra |
author_sort | Farkas, Szidónia |
collection | PubMed |
description | Estrogen is one of the most important female sex hormones, and is indispensable for reproduction. However, its role is much wider. Among others, due to its neuroprotective effects, estrogen protects the brain against dementia and complications of traumatic injury. Previously, it was used mainly as a therapeutic option for influencing the menstrual cycle and treating menopausal symptoms. Unfortunately, hormone replacement therapy might be associated with detrimental side effects, such as increased risk of stroke and breast cancer, raising concerns about its safety. Thus, tissue-selective and non-classical estrogen analogues have become the focus of interest. Here, we review the current knowledge about estrogen effects in a broader sense, and the possibility of using selective estrogen-receptor modulators (SERMs), selective estrogen-receptor downregulators (SERDs), phytoestrogens, and activators of non-genomic estrogen-like signaling (ANGELS) molecules as treatment. |
format | Online Article Text |
id | pubmed-9029610 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90296102022-04-23 Estradiol and Estrogen-like Alternative Therapies in Use: The Importance of the Selective and Non-Classical Actions Farkas, Szidónia Szabó, Adrienn Hegyi, Anita Emőke Török, Bibiána Fazekas, Csilla Lea Ernszt, Dávid Kovács, Tamás Zelena, Dóra Biomedicines Review Estrogen is one of the most important female sex hormones, and is indispensable for reproduction. However, its role is much wider. Among others, due to its neuroprotective effects, estrogen protects the brain against dementia and complications of traumatic injury. Previously, it was used mainly as a therapeutic option for influencing the menstrual cycle and treating menopausal symptoms. Unfortunately, hormone replacement therapy might be associated with detrimental side effects, such as increased risk of stroke and breast cancer, raising concerns about its safety. Thus, tissue-selective and non-classical estrogen analogues have become the focus of interest. Here, we review the current knowledge about estrogen effects in a broader sense, and the possibility of using selective estrogen-receptor modulators (SERMs), selective estrogen-receptor downregulators (SERDs), phytoestrogens, and activators of non-genomic estrogen-like signaling (ANGELS) molecules as treatment. MDPI 2022-04-06 /pmc/articles/PMC9029610/ /pubmed/35453610 http://dx.doi.org/10.3390/biomedicines10040861 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Farkas, Szidónia Szabó, Adrienn Hegyi, Anita Emőke Török, Bibiána Fazekas, Csilla Lea Ernszt, Dávid Kovács, Tamás Zelena, Dóra Estradiol and Estrogen-like Alternative Therapies in Use: The Importance of the Selective and Non-Classical Actions |
title | Estradiol and Estrogen-like Alternative Therapies in Use: The Importance of the Selective and Non-Classical Actions |
title_full | Estradiol and Estrogen-like Alternative Therapies in Use: The Importance of the Selective and Non-Classical Actions |
title_fullStr | Estradiol and Estrogen-like Alternative Therapies in Use: The Importance of the Selective and Non-Classical Actions |
title_full_unstemmed | Estradiol and Estrogen-like Alternative Therapies in Use: The Importance of the Selective and Non-Classical Actions |
title_short | Estradiol and Estrogen-like Alternative Therapies in Use: The Importance of the Selective and Non-Classical Actions |
title_sort | estradiol and estrogen-like alternative therapies in use: the importance of the selective and non-classical actions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029610/ https://www.ncbi.nlm.nih.gov/pubmed/35453610 http://dx.doi.org/10.3390/biomedicines10040861 |
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